influences on local leadership in Dutch water management

Processes of transformation, aimed at adaptation of environmental change, are often initiated in informal arenas where forerunners meet and breed. In order to connect such transformations to the existing socio-political context an adequate form of environmental governance is needed. This implies a key role for public decision-makers as gate keepers that can link an innovative policy proposal to the existing complexities of the government context in which social barriers, democratic obligations and the representation of existing routines that might be challenged by this innovation. This paper will focus on a radical change in the water management strategies of the South western delta area and specifically the resalinization of the Volkerak-Zoommeer. In the light of ecological rehabilitation and safety from possible flooding the need to restore this artificially maintained fresh water basin to its former state and allow influence of marine dynamics has been articulated. These adaptations provide several challenges for finding alternatives for the supply and use of fresh water to existing agriculture and industry. The role of local political leadership in the process of combining and synchronizing existing routines with innovations that require a change of these routines is regarded as essential. These connective capacities of leadership are subject to various influencing factors such as personal characteristics, the local and supra- local environment and institutional arrangements. Theoretically we distinguish leadership behavior in transactional, daring and transformational typologies. It would be hypothesized that daring leadership, which we conceptualize as a combination between transactional and transformational repertoires is most suitable for the successful coupling of innovative proposals with existing routines. Through empirical case study, the paper will explore key motivational elements resulting in specific leadership behavior as well as the ensuing possibilities for successful integration of the innovative proposals into existing policy

De invloed van contractuele en relationele aspecten op stakeholdermanagement:Een casusstudie van de A9 en A16 DBFM-infrastructuurprojecten

In the past decade, large infrastructure projects in the Netherlands have often been implemented through Public-Private Partnerships (PPPs), specifically using Design-Build-Finance-Maintain (DBFM) contracts. While the decision to implement projects through PPPs is based on expected advantages for internal parties – the public and private partners in the PPP –, there is a call for more focus on the advantages and disadvantages of PPPs for external stakeholders. External stakeholder management in DBFM projects is based on a contractual division of risks and responsibilities between the partners. However, it is clear from the literature that the contract does not guarantee successful stakeholder management. Relational aspects are important. Little research has been done, however, into the interplay of contractual and relational aspects in achieving successful stakeholder management. This article addresses this research need. A comparative case study was conducted into the PPP projects A9 Gaasperdammerweg and A16 Rotterdam. The study first shows that sanctions, when combined with a relational approach, have a positive effect on the relationships with stakeholders. Second, external stakeholder management cannot be simply outsourced to the private partner and continuous involvement of the public partner is important for success

Online web tool for data visualization

This deliverable lays out the work as done as part of MACSUR CropM on data, with the focus on providing a web tool for visualization of model output. It was decided early on that not a specific MACSUR web tool would be developed as part of MACSUR for phase 1, and mostly results would be visualized in other available tools, such as the Global Yield Gap Atlas, which are recognised resources for visualizations. Only in relationship to the MACSUR Geonetwork data catalog hosted at Aarhus University some developments where started. Operationally speaking, most data was still being generated during phase 1, so there was not enough to visualize on specific websites and partners did not commit financial resources to their development, and only in kind was available

Operation and Utilisation of the High Flux Reactor - Annual Report 2009

The High Flux Reactor (HFR) at Petten is managed by the Institute for Energy (IE) of the EC - DG JRC and operated by NRG who are also licence holder and responsible for commercial activities. The HFR operates at 45 MW and is of the tank-in-pool type, light water cooled and moderated. It is one of the most powerful multi-purpose materials testing reactors in the world and one of the world leaders in target irradiation for the production of medical radioisotopes.JRC.F-Institute for Energy and Transport (Petten

Adeno-associated virus mediated delivery of Tregitope 167 ameliorates experimental colitis

Aim: To explore the anti-inflammatory potential of adeno-associated virus-mediated delivery of Tregitope 167 in an experimental colitis model. Methods: The trinitrobenzene sulfonate (TNBS) model of induced colitis was used in Balb/c mice. Subsequently after intravenous adeno-associated virus-mediated regulatory T-cell epitopes (Tregitope) delivery, acute colitis was initiated by intra-rectal administration of 1.5 mg TNBS in 40% ethanol followed by a second treatment with TNBS (0.75 mg in 20% ethanol) 8 d later. Control groups included mice not treated with TNBS (healthy control group) and mice treated by TNBS only (diseased group). At the time of sacrifice colon weight, the disease activity index and histology damage score were determined. Immunohistochemical staining of the colonic tissues was performed to asses the cellular infiltrate and the presence of transcription factor forkhead Box-P3 (Foxp3). Thymus, mesenteric lymph nodes, liver and spleen tissue were collected and the corresponding lymphocyte populations were further assessed by flow cytometry analysis for the expression of CD4+ T cell and regulatory T cell associated markers. Results: The Tregitope 167 treated mice gained an average of 4% over their initial body weight at the time of sacrifice. In contrast, the mice treated with TNBS alone (no Tregitope) developed colitis, and lost 4% of their initial body weight at the time of sacrifice (P \u3c 0.01). The body weight increase that had been observed in the mice pre-treated with Tregitope 167 was substantiated by a lower disease activity index and a decreased colon weight as compared to the diseased control group (P \u3c 0.01 and P \u3c 0.001, respectively). Immunohistochemical staining of the colonic tissues for CD4+ showed that inflammatory cell infiltrates were present in TNBS treated mice with or without administration with tregitope 167 and that these cellular infiltrates consisted mainly of CD4+ cells. For both TNBS treated groups CD4+ T cell infiltrates were observed in the sub-epithelial layer and the lamina propria. CD4+ T cell infiltrates were also present in the muscularis mucosa layer of the diseased control mice, but were absent in the Tregitope 167 treated group. Numerous Foxp3 positive cells were detected in the lamina propria and sub-epithelium of the colon sections from mice treated with Tregitope 167. Furthermore, the Foxp3 and glycoprotein A repetitions predominant markers were significantly increased in the CD4+ T lymphocyte population in the thymus of the mice pre-treated with adeno-associated virus serotype 5 (cytomegalovirus promoter-Tregitope 167), as cytomegalovirus promoter compared to lymphocyte populations in the thymus of diseased and the healthy control mice (P \u3c 0.05 and P \u3c 0.001, respectively). Conclusion: This study identifies adeno-associated virus-mediated delivery of regulatory T-cell epitope 167 as a novel anti-inflammatory approach with the capacity to decrease intestinal inflammation and induce long-term remission in inflammatory bowel disease

Teaching tolerance

Babies born with Pompe disease require life-long treatment with enzyme-replacement therapy (ERT). Despite the human origin of the therapy, recombinant human lysosomal acid α glucosidase (GAA, rhGAA), ERT unfortunately leads to the development of high titers of anti-rhGAA antibody, decreased effectiveness of ERT, and a fatal outcome for a significant number of children who have Pompe disease. The severity of disease, anti-drug antibody (ADA) development, and the consequences thereof are directly related to the degree of the enzyme deficiency. Babies born with a complete deficiency GAA are said to have cross-reactive immunologic material (CRIM)–negative Pompe disease and are highly likely to develop GAA ADA. Less frequently, GAA ADA develop in CRIM-positive individuals. Currently, GAA-ADA sero-positive babies are treated with a combination of immunosuppressive drugs to induce immunological tolerance to ERT, but the long-term effect of these regimens is unknown. Alternative approaches that might redirect the immune response toward antigen-specific tolerance without immunosuppressive agents are needed. Methods leading to the induction of antigen-specific regulatory T cells (Tregs), using peptides such as Tregitopes (T regulatory cell epitopes) are under consideration for the future treatment of CRIM-negative Pompe disease. Tregitopes are natural T cell epitopes derived from immunoglobulin G (IgG) that cause the expansion and activation of regulatory T cells (Treg). Teaching the immune system to tolerate GAA by co-delivering GAA with Tregitope peptides might dramatically improve the lives of CRIM-negative babies and could be applied to other enzyme replacement therapies to which ADA have been induced

Data2Game: Towards an Integrated Demonstrator

The Data2Game project investigates how the efficacy of computerized training games can be enhanced by tailoring training scenarios to the individual player. The research is centered around three research innovations: (1) techniques for the automated modelling of players’ affective states, based on exhibited social signals, (2) techniques for the automated generation of in-game narratives tailored to the learning needs of the player, and (3) validated studies on the relation of the player behavior and game properties to learning performance. This paper describes the integration of the main results into a joint prototype

Operation and Utilisation of the High Flux Reactor - Annual Report 2012

The High Flux Reactor (HFR) at Petten is managed by the Institute for Energy and Transport (IET) of the European Commission's Joint Research Centre (JRC) and operated by the Nuclear Research and consultancy Group (NRG) which is also the licence holder and responsible for its commercial activities. The High Flux Reactor (HFR) operates at 45 MW and is of the tank-in-pool type, light water cooled and moderated. It is one of the most powerful multi-purpose materials testing reactors in the world and one of the world's leaders in target irradiation for the production of medical radioisotopes.JRC.F.4-Nuclear Reactor Integrity Assessment and Knowledge Managemen

Geriatric Screening, Triage Urgency, and 30-Day Mortality in Older Emergency Department Patients

BACKGROUND: Urgency triage in the emergency department (ED) is important for early identification of potentially lethal conditions and extensive resource utilization. However, in older patients, urgency triage systems could be improved by taking geriatric vulnerability into account. We investigated the association of geriatric vulnerability screening in addition to triage urgency levels with 30-day mortality in older ED patients. DESIGN: Secondary analysis of the observational multicenter Acutely Presenting Older Patient (APOP) study. SETTING: EDs within four Dutch hospitals. PARTICIPANTS: Consecutive patients, aged 70 years or older, who were prospectively included. MEASUREMENTS: Patients were triaged using the Manchester Triage System (MTS). In addition, the APOP screener was used as a geriatric screening tool. The primary outcome was 30-day mortality. Comparison was made between mortality within the geriatric high- and low-risk screened patients in every urgency triage category. We calculated the difference in explained variance of mortality by adding the geriatric screener (APOP) to triage urgency (MTS) by calculating Nagelkerke R2. RESULTS: We included 2,608 patients with a median age of 79 (interquartile range = 74-84) years, of whom 521 (20.0%) patients were categorized as high risk accor