The observable structure of persistence modules

In persistent topology, q-tame modules appear as a natural and large class of persistence modules indexed over the real line for which a persistence diagram is definable. However, unlike persistence modules indexed over a totally ordered finite set or the natural numbers, such diagrams do not provide a complete invariant of q-tame modules. The purpose of this paper is to show that the category of persistence modules can be adjusted to overcome this issue. We introduce the observable category of persistence modules: a localization of the usual category, in which the classical properties of q-tame modules still hold but where the persistence diagram is a complete isomorphism invariant and all q-tame modules admit an interval decomposition

Pathogenicity of anti-ADAMTS13 autoantibodies in acquired thrombotic thrombocytopenic purpura.

BACKGROUND: Acquired thrombotic thrombocytopenic purpura (TTP) is an autoimmune disease in which anti-ADAMTS13 autoantibodies cause severe enzyme deficiency. ADAMTS13 deficiency causes the loss of regulation of von Willebrand factor multimeric size and platelet-tethering function, which results in the formation of disseminated microvascular platelet microthrombi. Precisely how anti-ADAMTS13 autoantibodies, or antibody subsets, cause ADAMTS13 deficiency (ADAMTS13 activity generally < 10%) has not been formally investigated. METHODS: We analysed 92 acquired TTP episodes at presentation, through treatment and remission/relapse using epitope mapping and functional analyses to understand the pathogenic mechanisms of anti-ADAMTS13 IgG. RESULTS: 89/92 of TTP episodes had IgG recognising the ADAMTS13 N-terminal domains. The central spacer domain was the only N-terminal antigenic target detected. 38/92 TTP episodes had autoantibodies recognising the N-terminal domains alone; 54/92 TTP episodes also had antibodies against the ADAMTS13 C-terminal domains (TSP2-8 and/or CUB domains). Changes in autoantibody specificity were detected in 9/16 patients at relapse, suggesting a continued development of the disease. Functional analyses on IgG from 43 patients revealed inhibitory IgG were limited to anti-spacer domain antibodies. However, 15/43 patients had autoantibodies with no detectable inhibitory action and as many as 32/43 patients had autoantibodies with inhibitory function that was insufficient to account for the severe deficiency state, suggesting that in many patients there is an alternative pathogenic mechanism. We therefore analysed plasma ADAMTS13 antigen levels in 91 acquired TTP presentation samples. We demonstrated markedly reduced ADAMTS13 antigen levels in all presentation samples, median 6% normal (range 0-47%), with 84/91 patients having < 25% ADAMTS13 antigen. ADAMTS13 antigen in the lowest quartile at first presentation was associated with increased mortality (odds ratio 5.7). CONCLUSIONS: Anti-spacer domain autoantibodies are the major inhibitory antibodies in acquired TTP. However, depletion of ADAMTS13 antigen (rather than enzyme inhibition) is a dominant pathogenic mechanism. ADAMTS13 antigen levels at presentation have prognostic significance. Taken together, our results provide new insights into the pathophysiology of acquired TTP

Gender and the heat pump transition

Decarbonisation in moderate and cold climates is reliant on the replacement of existing heating technologies with electric heat pumps. Heat pumps work differently from incumbent technologies, including in how they are controlled, their distribution of heat around the home and their space requirements. Despite evidence that domestic practices and interests associated with women played an important role in previous heating transitions, policy and research have not yet considered how heat pumps might interact with traditionally gendered needs and concerns. This could have significant implications for the success of the heat pump transition. This synthesis uses a framework of evidenced heating needs, incorporating wellbeing, resources, ease of use and relational dynamics, to structure a narrative literature review on how experiences of heat pumps may be gendered. Indicative evidence suggests that heat pumps have the potential to improve female thermal comfort, but that other possibly gendered heating needs such as minimising perceived waste and easy controllability are not always addressed. Amidst a lack of empirical studies exploring women’s needs, and whether they are met by heat pumps, a series of recommendations is provided for multidisciplinary research on the topic and to enhance consideration of gendered needs and experiences in policy development

Microbiota is essential for social development in the mouse

No abstract available

A phylogenetic analysis of the British flora sheds light on the evolutionary and ecological factors driving plant invasions

Darwin's naturalization hypothesis predicts that invasive species should perform better in their novel range in the absence of close relatives in the native flora due to reduced competition. Evidence from recent taxonomic and phylogenetic-based studies, however, is equivocal. We test Darwin's naturalization hypothesis at two different spatial scales using a fossil-dated molecular phylogenetic tree of the British native and alien flora (ca. 1600 species) and extensive, fine-scale survey data from the 1998 Countryside Survey. At both landscape and local scales, invasive species were neither significantly more nor less related to the native flora than their non-invasive alien counterparts. Species invasiveness was instead correlated with higher nitrogen and moisture preference, but not other life history traits such as life-form and height. We argue that invasive species spread in Britain is hence more likely determined by changes in land use and other anthropogenic factors, rather than evolutionary history. Synthesis. The transition from non-invasive to invasive is not related to phylogenetic distinctiveness to the native community, but instead to their environmental preferences. Therefore, combating biological invasions in the Britain and other industrialized countries need entirely different strategies than in more natural environments

Dependency structure matrix modelling for stakeholder value networks

This paper develops a qualitative/quantitative network approach, namely a “Stakeholder Value Network”, to understand the impacts of both direct and indirect relationships between stakeholders on the success of large engineering projects. Specifically, this paper explores the feasibility and benefit of applying the Dependency Structure Matrix (DSM) as the modelling platform for Stakeholder Value Networks. Further, an efficient algorithm is designed for computing indirect stakeholder influence and implemented in a case study for a multinational energy project. The results derived from this analysis are able to answer three fundamental questions for stakeholder management: What are the critical paths/themes for a project to engage other stakeholders? Who are the most important stakeholders for a project? How can the complexity of a large relationship network be reasonably managed

Experimental evolution reveals high insecticide tolerance in Daphnia inhabiting farmland ponds

Exposure of nontarget populations to agricultural chemicals is an important aspect of global change. We quantified the capacity of natural Daphnia magna populations to locally adapt to insecticide exposure through a selection experiment involving carbaryl exposure and a control. Carbaryl tolerance after selection under carbaryl exposure did not increase significantly compared to the tolerance of the original field populations. However, there was evolution of a decreased tolerance in the control experimental populations compared to the original field populations. The magnitude of this decrease was positively correlated with land use intensity in the neighbourhood of the ponds from which the original populations were sampled. The genetic change in carbaryl tolerance in the control rather than in the carbaryl treatment suggests widespread selection for insecticide tolerance in the field associated with land use intensity and suggests that this evolution comes at a cost. Our data suggest a strong impact of current agricultural land use on nontarget natural Daphnia populations

Clifford-Jacobs Forging Company v. Capital Engineering & (and) Manufacturing Co.: The Continuing Problem within U.C.C. Section 2-207, 16 J. Marshall L. Rev. 589 (1983)

status: accepte

London's urban heat island: Impact on current and future energy consumption in office buildings

This article is available open access and shared under a Creative Commons license: (http://creativecommons.org/licenses/by/3.0/). Copyright @ 2011 Elsevier B.V.This paper presents the results of a computational study on the energy consumption and related CO2 emissions for heating and cooling of an office building within the Urban Heat Island of London, currently and in the future. The study developed twenty weather files in an East-West axis through London; the weather files were constructed according to future climate change scenario for 2050 suitable for the UK which have been modified to represent specific locations within the London UHI based on measurements and predictions from a program developed for this purpose (LSSAT). The study simulated an office with typical construction, heat gains and operational patterns with an advanced thermal simulation program (IESVE). The predictions confirm that heating load decreases, cooling load and overheating hours increase as the office location moves from rural to urban sites and from present to future years. It is shown that internal heat gains are an important factor affecting energy performance and that night cooling using natural ventilation will have a beneficial effect at rural and city locations. As overheating will increase in the future, more buildings will use cooling; it is shown that this might lead to a five-fold increase of CO2 emission for city centre offices in London in 2050. The paper presents detailed results of the typical office placed on the East-West axis of the city, arguing the necessity to consider using weather files based on climate projections and urbanheat island for the design of currentbuildings to safeguard their efficiency in the future.EPSR

Determinants of species richness in the Park Grass experiment

The Park Grass Experiment at Rothamsted in southeast England was started in 1856, making it the longest-running experiment in plant ecology anywhere in the world. Experimental inputs include a range of fertilizers (nitrogen, phosphorus, potassium, and organic manures) applied annually, with lime applied occasionally, and these have led to an increase in biomass and, where nitrogen was applied in the form of ammonium sulfate, to substantial decreases in soil pH. The number of species per plot varies from three to 44 per 200 m2, affording a unique opportunity to study the determinants of plant species richness and to estimate the effect sizes attributable to different factors. The response of species richness to biomass depends on the amount and type of nitrogen applied; richness declined monotonically with increasing biomass on plots receiving no nitrogen or receiving nitrogen in the form of sodium nitrate, but there was no relationship between species richness and biomass on plots acidified by ammonium sulfate application. The response to lime also depended on the type of nitrogen applied; there was no relationship between lime treatment and species richness, except in plots receiving nitrogen in the form of ammonium sulfate, where species richness increased sharply with increasing soil pH. The addition of phosphorus reduced species richness, and application of potassium along with phosphorus reduced species richness further, but the biggest negative effects were when nitrogen and phosphorus were applied together. The analysis demonstrates how multiple factors contribute to the observed diversity patterns and how environmental regulation of species pools can operate at the same spatial and temporal scale as biomass effects