5,208 research outputs found
Entanglement scaling at first order phase transitions
First order quantum phase transitions (1QPTs) are signaled, in the
thermodynamic limit, by discontinuous changes in the ground state properties.
These discontinuities affect expectation values of observables, including
spatial correlations. When a 1QPT is crossed in the vicinity of a second order
one (2QPT), due to the correlation length divergence of the latter, the
corresponding ground state is modified and it becomes increasingly difficult to
determine the order of the transition when the size of the system is finite.
Here we show that, in such situations, it is possible to apply finite size
scaling to entanglement measures, as it has recently been done for the order
parameters and the energy gap, in order to recover the correct thermodynamic
limit. Such a finite size scaling can unambigously discriminate between first
and second order phase transitions in the vicinity of multricritical points
even when the singularities displayed by entanglement measures lead to
controversial results
The Rhombi-Chain Bose-Hubbard Model: geometric frustration and interactions
We explore the effects of geometric frustration within a one-dimensional
Bose-Hubbard model using a chain of rhombi subject to a magnetic flux. The
competition of tunnelling, self-interaction and magnetic flux gives rise to the
emergence of a pair-superfluid (pair-Luttinger liquid) phase besides the more
conventional Mott-insulator and superfluid (Luttinger liquid) phases. We
compute the complete phase diagram of the model by identifying characteristic
properties of the pair-Luttinger liquid phase such as pair correlation
functions and structure factors and find that the pair-Luttinger liquid phase
is very sensitive to changes away from perfect frustration (half-flux). We
provide some proposals to make the model more resilient to variants away from
perfect frustration. We also study the bipartite entanglement properties of the
chain. We discover that, while the scaling of the block entropy pair-superfluid
and of the single-particle superfluid leads to the same central charge, the
properties of the low-lying entanglement spectrum levels reveal their
fundamental difference.Comment: 12 pages, 11 figure
Uptake of purines in <i>Plasmodium falciparum</i>-infected human erythrocytes is mostly mediated by the human Equilibrative Nucleoside Transporter and the human Facilitative Nucleobase Transporter
<b>Background</b>: Plasmodium parasites are unable to synthesize purines de novo and have to salvage them from the host. Due to this limitation in the parasite, purine transporters have been an area of focus in the search for anti-malarial drugs. Although the uptake of purines through the human equilibrative nucleoside transporter (hENT1), the human facilitative nucleobase transporter (hFNT1) and the parasite-induced new permeation pathway (NPP) has been studied, no information appears to exist on the relative contribution of these three transporters to the uptake of adenosine and hypoxanthine. Using the appropriate transporter inhibitors, the role of each of these salvage pathways to the overall purine transport in intraerythrocytic Plasmodium falciparum was systematically investigated.
<b>Methods</b>: The transport of adenosine, hypoxanthine and adenine into uninfected and P. falciparum-infected human erythrocytes was investigated in the presence or absence of classical inhibitors of the hFNT1, hENT1 and NPP. The effective inhibition of the various transporters by the classical inhibitors was verified using appropriate known substrates. The ability of high concentration of unlabelled substrates to saturate these transporters was also studied.
<b>Results</b>: Transport of exogenous purine into infected or uninfected erythrocytes occurred primarily through saturable transporters rather than through the NPP. Hypoxanthine and adenine appeared to enter erythrocytes mainly through the hFNT1 nucleobase transporter whereas adenosine entered predominantly through the hENT1 nucleoside transporter. The rate of purine uptake was approximately doubled in infected cells compared to uninfected erythrocytes. In addition, it was found that the rate of adenosine uptake was considerably higher than the rate of hypoxanthine uptake in infected human red blood cells (RBC). It was also demonstrated that furosemide inhibited the transport of purine bases through hFNT1.
<b>Conclusion</b>: Collectively, the data obtained in this study clearly show that the endogenous host erythrocyte transporters hENT1 and hFNT1, rather than the NPP, are the major route of entry of purine into parasitized RBC. Inhibitors of hENT1 and hFNT1, as well as the NPP, should be considered in the development of anti-malarials targeted to purine transport
On best rank one approximation of tensors
In this paper we suggest a new algorithm for the computation of a best rank
one approximation of tensors, called alternating singular value decomposition.
This method is based on the computation of maximal singular values and the
corresponding singular vectors of matrices. We also introduce a modification
for this method and the alternating least squares method, which ensures that
alternating iterations will always converge to a semi-maximal point. (A
critical point in several vector variables is semi-maximal if it is maximal
with respect to each vector variable, while other vector variables are kept
fixed.) We present several numerical examples that illustrate the computational
performance of the new method in comparison to the alternating least square
method.Comment: 17 pages and 6 figure
Eigenvectors of tensors and algorithms for Waring decomposition
A Waring decomposition of a (homogeneous) polynomial f is a minimal sum of
powers of linear forms expressing f. Under certain conditions, such a
decomposition is unique. We discuss some algorithms to compute the Waring
decomposition, which are linked to the equation of certain secant varieties and
to eigenvectors of tensors. In particular we explicitly decompose a general
cubic polynomial in three variables as the sum of five cubes (Sylvester
Pentahedral Theorem).Comment: 32 pages; three Macaulay2 files as ancillary files. Revised with
referee's suggestions. Accepted JS
The PI IRAP : an alternative scoring algorithm for the IRAP using a probabilistic semiparametric effect size measure
Development of reverse-transcription PCR techniques to analyse the density and sex ratio of gametocytes in genetically diverse Plasmodium chabaudi infections
We have developed cross-genotype and genotype-specific quantitative reverse-transcription PCR (qRT-PCR) assays to detect and quantify the number of parasites, transmission stages (gametocytes) and male gametocytes in blood stage Plasmodium chabaudi infections. Our cross-genotype assays are reliable, repeatable and generate counts that correlate strongly (R(2)s > 90%) with counts expected from blood smears. Our genotype-specific assays can distinguish and quantify different stages of genetically distinct parasite clones (genotypes) in mixed infections and are as sensitive as our cross-genotype assays. Using these assays we show that gametocyte density and gametocyte sex ratios vary during infections for two genetically distinct parasite lines (genotypes) and present the first data to reveal how sex ratio is affected when each genotype experiences competition in mixed-genotype infections. Successful infection of mosquito vectors depends on both gametocyte density and their sex ratio and we discuss the implications of competition in genetically diverse infections for transmission success
Nonlinear Dynamics of the Perceived Pitch of Complex Sounds
We apply results from nonlinear dynamics to an old problem in acoustical
physics: the mechanism of the perception of the pitch of sounds, especially the
sounds known as complex tones that are important for music and speech
intelligibility
Recent advances on IMF research
Here I discuss recent work on brown dwarfs, massive stars and the IMF in
general. The stellar IMF can be well described by an invariant two-part power
law in present-day star-formation events within the Local Group of galaxies. It
is nearly identical in shape to the pre-stellar core mass function. The
majority of brown dwarfs follow a separate IMF. Evidence from globular clusters
and ultra-compact dwarf galaxies has emerged that IMFs may have been top heavy
depending on the star-formation rate density. The IGIMF then ranges from bottom
heavy at low galaxy-wide star formation rates to being top-heavy in
galaxy-scale star bursts.Comment: 6 pages, LaTeX, to appear in The Labyrinth of Star Formation, 18-22
June 2012, Crete, (eds.) D. Stamatellos, S. Goodwin, and D. Ward-Thompson,
Springer, in press; replaced version: very minor corrections plus the
addition of reference Smith & Lucey (2013) on the bottom-heavy IMF in
elliptical galaxie
Astro2020 Science White Paper: Triggered High-Priority Observations of Dynamic Solar System Phenomena
Unexpected dynamic phenomena have surprised solar system observers in the
past and have led to important discoveries about solar system workings.
Observations at the initial stages of these events provide crucial information
on the physical processes at work. We advocate for long-term/permanent programs
on ground-based and space-based telescopes of all sizes - including Extremely
Large Telescopes (ELTs) - to conduct observations of high-priority dynamic
phenomena, based on a predefined set of triggering conditions. These programs
will ensure that the best initial dataset of the triggering event are taken;
separate additional observing programs will be required to study the temporal
evolution of these phenomena. While not a comprehensive list, the following are
notional examples of phenomena that are rare, that cannot be anticipated, and
that provide high-impact advances to our understandings of planetary processes.
Examples include: new cryovolcanic eruptions or plumes on ocean worlds; impacts
on Jupiter, Saturn, Uranus, or Neptune; extreme eruptions on Io; convective
superstorms on Saturn, Uranus, or Neptune; collisions within the asteroid belt
or other small-body populations; discovery of an interstellar object passing
through our solar system (e.g. 'Oumuamua); and responses of planetary
atmospheres to major solar flares or coronal mass ejections.Comment: Astro2020 white pape
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