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Taj mi je tip htio pokazati nešto tajno. Nešto zapanjujuće. Prema onome što mi je rekao, bio je to još neotkriven temelj kršćanstva. Tisućljećima najstrože čuvana tajna Crkve, as iz rukava koji još nije odigrala. Zaintrigiralo me. Odveo me u svojevrstan sanktuarij, koji je smrdio po vlazi, pa iz ormara s velikim ladicama stao vaditi relikvije u obliku čvrsto smotanih, požutjelih svežnjeva. Zatim ih je poslagao jedan pokraj drugog, kad gle – iz njih iziđe Djevica Marija. Moram priznati da me zapanjilo. Dogovorili smo spoj, našli se i prošetali po suncu i hladovini. Bila je ljubazna, nismo baš ćaskali, nego se više povezivali pomoću nasumičnih riječi koje su nas tjerale da se smješkamo i pogledavamo jedno drugo. Ali ono što me se najviše dojmilo: ona uopće nije bila povijesna ličnost, nije bila sveta, ni pobožna, ni odjevena u halju! Bila je obična djevojka. Nije se bojala i rado se smijala. Razumjeli smo se. Dok je hodala, donji dio leđa blago bi joj se izvio u nježan luk, i bila je lijepa i prilično moderna. Zbog zaigranog koraka stopala u sandalama bila su joj prašnjava, pomalo je i vukla noge, a kad bi zastala, nožnim bi prstima čeprkala po zemlji. Dok smo šetali, bio sam zadivljen: bila je to Djevica Marija, Kristova majka, glavom i bradom, premda, naravno, iz mlađih dana. Pa ipak, kakav uspjeh za Crkvu! Kad sam čitao rimsku književnost iz doba prije Krista, sjećam se, učinila mi se zabavnom i modernom – i znao sam da bi takva mogla biti i ona. Moderna. I zabavna

Investigating the Unmet Need and Future of Neurorehabilitation in India: A Scoping Review

Objectives: This study explores the challenges of implementing physical rehabilitation for people with neurological diseases at in-hospital and community levels in India, summarizes the unmet needs of evidence-based physical neurorehabilitation in India, and explores the potential models/services that can enhance the delivery of physical rehabilitation for people with neurological diseases in India. Methods: Following the preferred reporting items for systematic reviews and meta-analysis guidelines, a scoping review was conducted, employing predefined criteria to identify 28 eligible studies for analysis. Meanwhile, by employing a narrative synthesis approach, the authors collated and summarized the data extracted from these studies to gain insights into the challenges and current requirements for neurorehabilitation in India. The narrative synthesis method facilitated the exploration of qualitative aspects, allowing for a comprehensive examination of the synthesized evidence. Results: Rehabilitation after a stroke was the primary focus of the majority of the 28 research. Rehabilitation (a), rehabilitation (b) supply of rehabilitation, rehabilitation (c) research on rehabilitation, and socioeconomic issues (d) were the four main headings used to explain the present difficulties and unfulfilled demands. We also suggested eight “models of care” based on proven strategies that have been tested before and might help address current deficiencies. Discussion: Neurorehabilitation in India is inadequate, with a lack of skilled professionals, poor accessibility to services and a rural-urban divide.Alternative models of rehabilitation provision, including multidisciplinary care, task-shifting, caregiver-led and self-help models, could address the unmet needs. Trials have explored home-based caregiver-led and technology-based models, but modifications and cultural specificity are needed. Stakeholders must mobilize support and advocate for rehabilitation’s role and value, with improved data collection and reporting to inform policy development. Conclusion: There is no one-size-fits-all solution to the diverse challenges and needs of neurorehabilitation delivery in India. Several alternative care models seem to have future promise, albeit unfulfilled demands. Some basic steps toward progress include raising public awareness, enhancing the skills of current experts and encouraging proactive engagement from state and federal governments and other interested parties

Expression and function of G-protein-coupled receptorsin the male reproductive tract

This review focuses on the expression and function of muscarinic acetylcholine receptors (mAChRs), α1-adrenoceptors and relaxin receptors in the male reproductive tract. The localization and differential expression of mAChR and α1-adrenoceptor subtypes in specific compartments of the efferent ductules, epididymis, vas deferens, seminal vesicle and prostate of various species indicate a role for these receptors in the modulation of luminal fluid composition and smooth muscle contraction, including effects on male fertility. Furthermore, the activation of mAChRs induces transactivation of the epidermal growth factor receptor (EGFR) and the Sertoli cell proliferation. The relaxin receptors are present in the testis, RXFP1 in elongated spermatids and Sertoli cells from rat, and RXFP2 in Leydig and germ cells from rat and human, suggesting a role for these receptors in the spermatogenic process. The localization of both receptors in the apical portion of epithelial cells and smooth muscle layers of the vas deferens suggests an involvement of these receptors in the contraction and regulation of secretion.Esta revisão enfatiza a expressão e a função dos receptores muscarínicos, adrenoceptores α1 e receptores para relaxina no sistema reprodutor masculino. A expressão dos receptores muscarínicos e adrenoceptores α1 em compartimentos específicos de dúctulos eferentes, epidídimo, ductos deferentes, vesícula seminal e próstata de várias espécies indica o envolvimento destes receptores na modulação da composição do fluido luminal e na contração do músculo liso, incluindo efeitos na fertilidade masculina. Além disso, a ativação dos receptores muscarínicos leva à transativação do receptor para o fator crescimento epidermal e proliferação das células de Sertoli. Os receptores para relaxina estão presentes no testículo, RXFP1 nas espermátides alongadas e células de Sertoli de rato e RXFP2 nas células de Leydig e germinativas de ratos e humano, sugerindo o envolvimento destes receptores no processo espermatogênico. A localização de ambos os receptores na porção apical das células epiteliais e no músculo liso dos ductos deferentes de rato sugere um papel na contração e na regulação da secreção.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de FarmacologiaUNIFESP, EPM, Depto. de FarmacologiaSciEL

SHIFT: Shared History Instruction Fetch for Lean-core Server Processors

Z IN (SINGLE) = 800