Discrete Optimization for Interpretable Study Populations and Randomization Inference in an Observational Study of Severe Sepsis Mortality

Motivated by an observational study of the effect of hospital ward versus intensive care unit admission on severe sepsis mortality, we develop methods to address two common problems in observational studies: (1) when there is a lack of covariate overlap between the treated and control groups, how to define an interpretable study population wherein inference can be conducted without extrapolating with respect to important variables; and (2) how to use randomization inference to form confidence intervals for the average treatment effect with binary outcomes. Our solution to problem (1) incorporates existing suggestions in the literature while yielding a study population that is easily understood in terms of the covariates themselves, and can be solved using an efficient branch-and-bound algorithm. We address problem (2) by solving a linear integer program to utilize the worst case variance of the average treatment effect among values for unobserved potential outcomes that are compatible with the null hypothesis. Our analysis finds no evidence for a difference between the sixty day mortality rates if all individuals were admitted to the ICU and if all patients were admitted to the hospital ward among less severely ill patients and among patients with cryptic septic shock. We implement our methodology in R, providing scripts in the supplementary material

Heavy Quark Potential from Gauge/Gravity Duality: A Large D Analysis

The heavy-quark potential is calculated in the framework of gauge/gravity duality using the large-D approximation, where D is the number of dimensions transverse to the flux tube connecting a quark and an antiquark in a flat D+2-dimensional spacetime. We find that in the large-D limit the leading correction to the ground-state energy, as given by an effective Nambu-Goto string, arises not from the heavy modes but from the behavior of the massless modes in the vicinity of the quark and the antiquark. We estimate this correction and find that it should be visible in the near-future lattice QCD calculations of the heavy-quark potential.Comment: 22 pages, 5 Figures. v2: references added, typos corrected and, Sec. 4 rewritten with an expanded non-perturbative discussion of the corrections to the Arvis potential arising from the massless modes near the boundary of the qcd strin

Time-dependent Circulation Flows: Iron Enrichment in Cooling Flows with Heated Return Flows

We describe a new type of dynamical model for hot gas in galaxy groups and clusters in which gas moves simultaneously in both radial directions. Circulation flows are consistent with (1) the failure to observe cooling gas in X-ray spectra, (2) multiphase gas observed near the centers of these flows and (3) the accumulation of iron in the hot gas from Type Ia supernovae in the central galaxy. Dense inflowing gas cools, producing a positive central temperature gradient, as in normal cooling flows. Bubbles of hot, buoyant gas flow outward. Circulation flows eventually cool catastrophically if the outward flowing gas transports mass but no heat; to maintain the circulation both mass and energy must be supplied to the inflowing gas over a large volume, extending to the cooling radius. The rapid radial recirculation of gas produces a flat central core in the gas iron abundance, similar to many observations. We believe the circulation flows described here are the first gasdynamic, long-term evolutionary models that are in good agreement with all essential features observed in the hot gas: little or no gas cools as required by XMM spectra, the gas temperature increases outward near the center, and the gaseous iron abundance is about solar near the center and decreases outward.Comment: 17 pages (emulateapj5) with 6 figures; accepted by The Astrophysical Journa

Tapping Spin Glasses

We consider a tapping dynamics, analogous to that in experiments on granular media, on spin glasses and ferromagnets on random thin graphs. Between taps, zero temperature single spin flip dynamics takes the system to a metastable state. Tapping, corresponds to flipping simultaneously any spin with probability $p$. This dynamics leads to a stationary regime with a steady state energy $E(p)$. We analytically solve this dynamics for the one dimensional ferromagnet and $\pm J$ spin glass. Numerical simulations for spin glasses and ferromagnets of higher connectivity are carried out, in particular we find a novel first order transition for the ferromagnetic systems.Comment: 5 pages, 3 figures, RevTe

Random RNA under tension

The Laessig-Wiese (LW) field theory for the freezing transition of random RNA secondary structures is generalized to the situation of an external force. We find a second-order phase transition at a critical applied force f = f_c. For f f_c, the extension L as a function of pulling force f scales as (f-f_c)^(1/gamma-1). The exponent gamma is calculated in an epsilon-expansion: At 1-loop order gamma = epsilon/2 = 1/2, equivalent to the disorder-free case. 2-loop results yielding gamma = 0.6 are briefly mentioned. Using a locking argument, we speculate that this result extends to the strong-disorder phase.Comment: 6 pages, 10 figures. v2: corrected typos, discussion on locking argument improve

Diffusion-induced Ramsey narrowing

A novel form of Ramsey narrowing is identified and characterized. For long-lived coherent atomic states coupled by laser fields, the diffusion of atoms in-and-out of the laser beam induces a spectral narrowing of the atomic resonance lineshape. Illustrative experiments and an intuitive analytical model are presented for this diffusion-induced Ramsey narrowing, which occurs commonly in optically-interrogated systems.Comment: 4 pages, 8 figure

External stress-corrosion cracking of a 1.22-m-diameter type 316 stainless steel air valve

An investigation was conducted to determine the cause of the failure of a massive AISI Type 316 stainless steel valve which controlled combustion air to a jet engine test facility. Several through-the-wall cracks were present near welded joints in the valve skirt. The valve had been in outdoor service for 18 years. Samples were taken in the cracked regions for metallographic and chemical analyses. Insulating material and sources of water mist in the vicinity of the failed valve were analyzed for chlorides. A scanning electron microscope was used to determine whether foreign elements were present in a crack. On the basis of the information generated, the failure was characterized as external stress-corrosion cracking. The cracking resulted from a combination of residual tensile stress from welding and the presence of aqueous chlorides. Recommended countermeasures are included

Characterizing Planetary Orbits and the Trajectories of Light

Exact analytic expressions for planetary orbits and light trajectories in the Schwarzschild geometry are presented. A new parameter space is used to characterize all possible planetary orbits. Different regions in this parameter space can be associated with different characteristics of the orbits. The boundaries for these regions are clearly defined. Observational data can be directly associated with points in the regions. A possible extension of these considerations with an additional parameter for the case of Kerr geometry is briefly discussed.Comment: 49 pages total with 11 tables and 10 figure

Low-energy vibrational density of states of plasticized poly(methyl methacrylate)

The low-energy vibrational density of states (VDOS)of hydrogenated or deuterated poly(methyl methacrylate)(PMMA)plasticized by dibutyl phtalate (DBP) is determined by inelastic neutron scattering.From experiment, it is equal to the sum of the ones of the PMMA and DBP components.However, a partition of the total low-energy VDOS among PMMA and DBP was observed.Contrary to Raman scattering, neutron scattering does not show enhancement of the boson peak due to plasticization.Comment: 9 pages, 2 figures (Workshop on Disordered Systems, Andalo