Micro-Hole and Strip Plate (MHSP) operation in CF4

The Micro-Hole and Strip Plate (MHSP) is a hybrid electron multiplier which combines the working principles of a Gas Electron Multiplier (GEM) and a Micro-Strip Gas Counter (MSGC). The compact double stage electron multiplication processes found in the MHSP enables the realisation of higher gas gain than the lone GEM operation. Thermal neutron detection using gas detectors involves the use of gas with another suitable stopping gas, operated at elevated pressure to confine the products of the neutron- reaction. It is, however, well known that the gain of GEMs drops too sharply with increasing chamber pressure.http://www.sciencedirect.com/science/article/B6TJM-4NS2G9V-D/1/497af6476b376b1c2f407a3fa7ff735

Association of comorbidity and health service usage among patients with dementia in the UK: a population-based study

$\textbf{BACKGROUND}$: The majority of people with dementia have other long-term diseases, the presence of which may affect the progression and management of dementia. This study aimed to identify subgroups with higher healthcare needs, by analysing how primary care consultations, number of prescriptions and hospital admissions by people with dementia varies with having additional long-term diseases (comorbidity). $\textbf{METHODS}$: A retrospective cohort study based on health data from the Clinical Practice Research Datalink (CPRD) was conducted. Incident cases of dementia diagnosed in the year starting 1/3/2008 were selected and followed for up to 5 years. The number of comorbidities was obtained from a set of 34 chronic health conditions. Service usage (primary care consultations, hospitalisations and prescriptions) and time-to-death were determined during follow-up. Multilevel negative binomial regression and Cox regression, adjusted for age and gender, were used to model differences in service usage and death between differing numbers of comorbidities. $\textbf{RESULTS}$: Data from 4999 people (14 866 person-years of follow-up) were analysed. Overall, 91.7% of people had 1 or more additional comorbidities. Compared with those with 2 or 3 comorbidities, people with ≥6 comorbidities had higher rates of primary care consultations (rate ratio (RR) 1.31, 95% CI 1.25 to 1.36), prescriptions (RR 1.68, 95% CI 1.57 to 1.81), and hospitalisation (RR 1.62, 95% CI 1.44 to 1.83), and higher risk of death (HR 1.56, 95% CI 1.37 to 1.78). $\textbf{DISCUSSION}$: In the UK, people with dementia with higher numbers of comorbidities die earlier and have considerably higher health service usage in terms of primary care consultations, hospital admissions and prescribing. This study provides strong evidence that comorbidity is a key factor that should be considered when allocating resources and planning care for people with dementia

Loneliness in Psychosis: A Meta-analytical Review

Loneliness may be related to psychotic symptoms but a comprehensive synthesis of the literature in this area is lacking. The aim of the current study is to determine the magnitude and reliability of the loneliness-psychosis relationship in people diagnosed with schizophrenia or related disorders, taking into account study quality, and whether it is moderated by method of assessment. A search of electronic databases was conducted (PsychINFO, MEDLINE, EMBASE and Web of Science). A random effects meta-analysis was used to compute a pooled estimate of the correlation between loneliness and psychotic symptoms. Study and outcome quality were assessed using adapted versions of the Agency for Healthcare Research and Quality (AHRQ) tool and GRADE approach, respectively. Thirteen studies were included, providing data from 15,647 participants. A moderate association between psychosis and loneliness was observed (k=13, N=15,647, r=0.32, 95% CI 0.20, 0.44; I2 97.56%; moderate quality evidence). Whether loneliness was assessed by a single-item or a more comprehensive measure had no moderating effect on the estimate. Results indicate that there is a significant positive relationship between loneliness and psychosis. Further studies are needed to determine the causal status of this relationship, but this robust finding should be considered in clinical practice and treatment provision for those with psychotic disorders

Observations of a radio-bright, X-ray obscured GRS 1915+105

The Galactic black hole transient GRS1915+105 is famous for its markedly variable X-ray and radio behaviour, and for being the archetypal galactic source of relativistic jets. It entered an X-ray outburst in 1992 and has been active ever since. Since 2018 GRS1915+105 has declined into an extended low-flux X-ray plateau, occasionally interrupted by multi-wavelength flares. Here we report the radio and X-ray properties of GRS1915+105 collected in this new phase, and compare the recent data to historic observations. We find that while the X-ray emission remained unprecedentedly low for most of the time following the decline in 2018, the radio emission shows a clear mode change half way through the extended X-ray plateau in 2019 June: from low flux (~3mJy) and limited variability, to marked flaring with fluxes two orders of magnitude larger. GRS1915+105 appears to have entered a low-luminosity canonical hard state, and then transitioned to an unusual accretion phase, characterised by heavy X-ray absorption/obscuration. Hence, we argue that a local absorber hides from the observer the accretion processes feeding the variable jet responsible for the radio flaring. The radio-X-ray correlation suggests that the current low X-ray flux state may be a signature of a super-Eddington state akin to the X-ray binaries SS433 or V404 Cyg

Further studies on the gain properties of a Gas Electron Multiplier with a Micro-Induction Gap Amplifying Structure (GEM-MIGAS) aimed at low-energy X-ray detection

A Gas Electron Multiplier with Micro-Induction Gap Amplifying Structure (GEM-MIGAS) is formed when the induction gap of the GEM is set between 50 and 100 [mu]m using kapton pillars spaced at regular intervals. This configuration combines the properties of a GEM and Micromegas, allowing operation in tandem to generate high charge gains. We measured the essential operational parameters of this system using argon-isobutane (IB) and helium-IB gas mixtures. The present short induction gap GEM was able to achieve effective gains exceeding 2×104 using argon-IB and 105 using helium-IB mixtures. In view of the high gains achieved, particularly when using helium-based gas mixtures, these studies confirmed the possibility of using the present system for high-performance sub-keV X-ray detection.http://www.sciencedirect.com/science/article/B6TJM-4P61N30-5/1/fb32483bc2ec5006bc9641ac8675ee9

Nitrides as ammonia synthesis catalysts and as potential nitrogen transfer reagents

In this article, an overview of the application of selected metal nitrides as ammonia synthesis catalysts is presented. The potential development of some systems into nitrogen transfer reagents is also described

How do you say ‘hello’? Personality impressions from brief novel voices

On hearing a novel voice, listeners readily form personality impressions of that speaker. Accurate or not, these impressions are known to affect subsequent interactions; yet the underlying psychological and acoustical bases remain poorly understood. Furthermore, hitherto studies have focussed on extended speech as opposed to analysing the instantaneous impressions we obtain from first experience. In this paper, through a mass online rating experiment, 320 participants rated 64 sub-second vocal utterances of the word ‘hello’ on one of 10 personality traits. We show that: (1) personality judgements of brief utterances from unfamiliar speakers are consistent across listeners; (2) a two-dimensional ‘social voice space’ with axes mapping Valence (Trust, Likeability) and Dominance, each driven by differing combinations of vocal acoustics, adequately summarises ratings in both male and female voices; and (3) a positive combination of Valence and Dominance results in increased perceived male vocal Attractiveness, whereas perceived female vocal Attractiveness is largely controlled by increasing Valence. Results are discussed in relation to the rapid evaluation of personality and, in turn, the intent of others, as being driven by survival mechanisms via approach or avoidance behaviours. These findings provide empirical bases for predicting personality impressions from acoustical analyses of short utterances and for generating desired personality impressions in artificial voices

Dynamic and volumetric variables reliably predict fluid responsiveness in a porcine model with pleural effusion

Background: The ability of stroke volume variation (SVV), pulse pressure variation (PPV) and global end-diastolic volume (GEDV) for prediction of fluid responsiveness in presence of pleural effusion is unknown. The aim of the present study was to challenge the ability of SVV, PPV and GEDV to predict fluid responsiveness in a porcine model with pleural effusions. Methods: Pigs were studied at baseline and after fluid loading with 8 ml kg−1 6% hydroxyethyl starch. After withdrawal of 8 ml kg−1 blood and induction of pleural effusion up to 50 ml kg−1 on either side, measurements at baseline and after fluid loading were repeated. Cardiac output, stroke volume, central venous pressure (CVP) and pulmonary occlusion pressure (PAOP) were obtained by pulmonary thermodilution, whereas GEDV was determined by transpulmonary thermodilution. SVV and PPV were monitored continuously by pulse contour analysis. Results: Pleural effusion was associated with significant changes in lung compliance, peak airway pressure and stroke volume in both responders and non-responders. At baseline, SVV, PPV and GEDV reliably predicted fluid responsiveness (area under the curve 0.85 (p<0.001), 0.88 (p<0.001), 0.77 (p = 0.007). After induction of pleural effusion the ability of SVV, PPV and GEDV to predict fluid responsiveness was well preserved and also PAOP was predictive. Threshold values for SVV and PPV increased in presence of pleural effusion. Conclusions: In this porcine model, bilateral pleural effusion did not affect the ability of SVV, PPV and GEDV to predict fluid responsiveness

Climate change adaptation, flood risks and policy coherence in integrated water resources management in England

Integrated water resources management (IWRM) assumes coherence between cognate aspects of water governance at the river basin scale, for example water quality, energy production and agriculture objectives. But critics argue that IWRM is often less ‘integrated’ in practice, raising concerns over inter-sectoral coherence between implementing institutions. One increasingly significant aspect of IWRM is adaptation to climate change-related risks, including threats from flooding, which are particularly salient in England. Although multiple institutional mechanisms exist for flood risk management (FRM), their coherence remains a critical question for national adaptation. This paper therefore (1) maps the multi-level institutional frameworks determining both IWRM and FRM in England; (2) examines their interaction via various inter-institutional coordinating mechanisms; and (3) assesses the degree of coherence. The analysis suggests that cognate EU strategic objectives for flood risk assessment demonstrate relatively high vertical and horizontal coherence with river basin planning. However, there is less coherence with flood risk requirements for land-use planning and national flood protection objectives. Overall, this complex governance arrangement actually demonstrates de-coherence over time due to ongoing institutional fragmentation. Recommendations for increasing IWRM coherence in England or re-coherence based on greater spatial planning and coordination of water-use and land-use strategies are proposed