Effect of pelvic stabilization and hip position on trunk extensor activity during back extension exercises on a roman chair

Objective: To assess the effect of pelvic stabilization and hip position on the electromyographic activity of trunk extensors during Roman chair exercise. A secondary objective was to compare genders. Design: Repeated measures. Subjects: Eleven men and 11 women volunteers. Methods: Five trunk flexion-extension cycles for 3 Roman chair conditions: (i) pelvis unrestrained; (ii) pelvis restrained; and (iii) hip at 40° flexion. Electromyographic signals were recorded on the back muscles, as well as on the gluteus maximus and biceps femoris. The percentage of electro¬myographic amplitude relative to the maximal activity was used to assess the level of muscular activation of each muscle group across the exercises. Results: For both genders, the Roman chair conditions did not influence the activity of the back and gluteus muscles. The hip-at-40°-flexion condition significantly reduced the activity of the biceps femoris (average of 4–18%) relative to the other 2 conditions. Gender differences were observed on the activity of the biceps femoris in all Roman chair conditions. Conclusion: The hip-at-40°-flexion condition would allow the Roman chair exercise to train the targeted back muscles more specifically by overloading them over a longer duration in order to induce physiological changes

Exogenous Fibrolytic Enzymes and Length of Storage Affect the Nutritive Value and Fermentation Profile of Maize Silage

The addition of exogenous fibrolytic enzymes (EFEs) and length of storage can affect the quality of maize silage. Therefore, the objective of this study was to evaluate the fermentative profile and the nutritive value of maize silage treated with different doses of EFEs ensiled for 30, 60, or 90 days. The study was designed as completely randomized in a split-plot arrangement of treatments, where four doses of EFEs were assigned to the main plot and three lengths of storage to the sub-plot, with four replicates per treatment. Treatments were: Control, E100 (EFEs at 100 g/ton dry matter (DM)), E150 (EFEs at 150 g/ton DM) and E200 (EFEs at 200 g/ton DM). The EFE treatment did not increase the digestibility of nutrients but increased the acetic acid concentration (1.87 vs. 1.18% DM), while decreasing the content of ethanol (0.02 vs. 0.08% DM), ethyl lactate (7.50 vs. 15.9 mg/DM) and ethyl acetate (5.58 vs. 10.6 mg/DM). Prolonged storage increased DM losses (7.05 vs. 2.32%) and acetic acid content (2.19 vs. 1.03% DM), but decreased ethanol concentration (0.02 vs. 0.09% DM). In conclusion, the addition of EFEs in maize silages did not affect nutrient digestibility and DM losses during fermentation, but it slightly decreased the concentrations of ethanol and esters and increased the acetic acid content. Although statistically significant, such differences may not be relevant biologically, due to the relatively low concentrations of ethanol and esters in all treatments

Interpretation of the transpulmonary thermodilution curve in the presence of a left-to-right shunt

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Photon Production from Nonequilibrium Disoriented Chiral Condensates in a Spherical Expansion

We study the production of photons through the non-equilibrium relaxation of a disoriented chiral condensate formed in the expanding hot central region in ultra-relativistic heavy-ion collisions. It is found that the expansion smoothes out the resonances in the process of parametric amplification such that the non-equilibrium photons are dominant to the thermal photons over the range 0.2-2 GeV. We propose that to search for non-equilibrium photons in the direct photon measurements of heavy-ion collisions can be a potential test of the formation of disoriented chiral condensates.Comment: 13 pages, 3 figure

Fluorescence characterization of clinically-important bacteria

Healthcare-associated infections (HCAI/HAI) represent a substantial threat to patient health during hospitalization and incur billions of dollars additional cost for subsequent treatment. One promising method for the detection of bacterial contamination in a clinical setting before an HAI outbreak occurs is to exploit native fluorescence of cellular molecules for a hand-held, rapid-sweep surveillance instrument. Previous studies have shown fluorescence-based detection to be sensitive and effective for food-borne and environmental microorganisms, and even to be able to distinguish between cell types, but this powerful technique has not yet been deployed on the macroscale for the primary surveillance of contamination in healthcare facilities to prevent HAI. Here we report experimental data for the specification and design of such a fluorescence-based detection instrument. We have characterized the complete fluorescence response of eleven clinically-relevant bacteria by generating excitation-emission matrices (EEMs) over broad wavelength ranges. Furthermore, a number of surfaces and items of equipment commonly present on a ward, and potentially responsible for pathogen transfer, have been analyzed for potential issues of background fluorescence masking the signal from contaminant bacteria. These include bedside handrails, nurse call button, blood pressure cuff and ward computer keyboard, as well as disinfectant cleaning products and microfiber cloth. All examined bacterial strains exhibited a distinctive double-peak fluorescence feature associated with tryptophan with no other cellular fluorophore detected. Thus, this fluorescence survey found that an emission peak of 340nm, from an excitation source at 280nm, was the cellular fluorescence signal to target for detection of bacterial contamination. The majority of materials analysed offer a spectral window through which bacterial contamination could indeed be detected. A few instances were found of potential problems of background fluorescence masking that of bacteria, but in the case of the microfiber cleaning cloth, imaging techniques could morphologically distinguish between stray strands and bacterial contamination

Cinteny: flexible analysis and visualization of synteny and genome rearrangements in multiple organisms

BACKGROUND: Identifying syntenic regions, i.e., blocks of genes or other markers with evolutionary conserved order, and quantifying evolutionary relatedness between genomes in terms of chromosomal rearrangements is one of the central goals in comparative genomics. However, the analysis of synteny and the resulting assessment of genome rearrangements are sensitive to the choice of a number of arbitrary parameters that affect the detection of synteny blocks. In particular, the choice of a set of markers and the effect of different aggregation strategies, which enable coarse graining of synteny blocks and exclusion of micro-rearrangements, need to be assessed. Therefore, existing tools and resources that facilitate identification, visualization and analysis of synteny need to be further improved to provide a flexible platform for such analysis, especially in the context of multiple genomes. RESULTS: We present a new tool, Cinteny, for fast identification and analysis of synteny with different sets of markers and various levels of coarse graining of syntenic blocks. Using Hannenhalli-Pevzner approach and its extensions, Cinteny also enables interactive determination of evolutionary relationships between genomes in terms of the number of rearrangements (the reversal distance). In particular, Cinteny provides: i) integration of synteny browsing with assessment of evolutionary distances for multiple genomes; ii) flexibility to adjust the parameters and re-compute the results on-the-fly; iii) ability to work with user provided data, such as orthologous genes, sequence tags or other conserved markers. In addition, Cinteny provides many annotated mammalian, invertebrate and fungal genomes that are pre-loaded and available for analysis at . CONCLUSION: Cinteny allows one to automatically compare multiple genomes and perform sensitivity analysis for synteny block detection and for the subsequent computation of reversal distances. Cinteny can also be used to interactively browse syntenic blocks conserved in multiple genomes, to facilitate genome annotation and validation of assemblies for newly sequenced genomes, and to construct and assess phylogenomic trees

Establishing a core outcome set for peritoneal dialysis : report of the SONG-PD (standardized outcomes in nephrology-peritoneal dialysis) consensus workshop

Outcomes reported in randomized controlled trials in peritoneal dialysis (PD) are diverse, are measured inconsistently, and may not be important to patients, families, and clinicians. The Standardized Outcomes in Nephrology-Peritoneal Dialysis (SONG-PD) initiative aims to establish a core outcome set for trials in PD based on the shared priorities of all stakeholders. We convened an international SONG-PD stakeholder consensus workshop in May 2018 in Vancouver, Canada. Nineteen patients/caregivers and 51 health professionals attended. Participants discussed core outcome domains and implementation in trials in PD. Four themes relating to the formation of core outcome domains were identified: life participation as a main goal of PD, impact of fatigue, empowerment for preparation and planning, and separation of contributing factors from core factors. Considerations for implementation were identified: standardizing patient-reported outcomes, requiring a validated and feasible measure, simplicity of binary outcomes, responsiveness to interventions, and using positive terminology. All stakeholders supported inclusion of PD-related infection, cardiovascular disease, mortality, technique survival, and life participation as the core outcome domains for PD

Crises and collective socio-economic phenomena: simple models and challenges

Financial and economic history is strewn with bubbles and crashes, booms and busts, crises and upheavals of all sorts. Understanding the origin of these events is arguably one of the most important problems in economic theory. In this paper, we review recent efforts to include heterogeneities and interactions in models of decision. We argue that the Random Field Ising model (RFIM) indeed provides a unifying framework to account for many collective socio-economic phenomena that lead to sudden ruptures and crises. We discuss different models that can capture potentially destabilising self-referential feedback loops, induced either by herding, i.e. reference to peers, or trending, i.e. reference to the past, and account for some of the phenomenology missing in the standard models. We discuss some empirically testable predictions of these models, for example robust signatures of RFIM-like herding effects, or the logarithmic decay of spatial correlations of voting patterns. One of the most striking result, inspired by statistical physics methods, is that Adam Smith's invisible hand can badly fail at solving simple coordination problems. We also insist on the issue of time-scales, that can be extremely long in some cases, and prevent socially optimal equilibria to be reached. As a theoretical challenge, the study of so-called "detailed-balance" violating decision rules is needed to decide whether conclusions based on current models (that all assume detailed-balance) are indeed robust and generic.Comment: Review paper accepted for a special issue of J Stat Phys; several minor improvements along reviewers' comment