Recommendations from the Association for European Paediatric Cardiology for training in paediatric cardiac intensive care: AEPC's recommendations for European paediatric cardiology trainees The Working Group on Paediatric Cardiac Intensive Care

The following document provides a summary of the guidelines and recommendations for paediatric cardiac intensive care training as a requirement for recognition as a European paediatric cardiologist. It is therefore primarily targeting paediatric cardiology trainees in Europe, including those doctors who might wish to become experts in cardiac intensive care. These recommendations represent a frame for consistency, will evolve, and may be adapted to specific institutional requirements. They will be complemented by a learning module to be provided by our Association in the near futur

Scalable Physical Layer Security Components for Microservice-Based Optical SDN Controllers

We propose and demonstrate a set of microservice-based security components able to perform physical layer security assessment and mitigation in optical networks. Results illustrate the scalability of the attack detection mechanism and the agility in mitigating attacks

Children and older adults exhibit distinct sub-optimal cost-benefit functions when preparing to move their eyes and hands

"© 2015 Gonzalez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited"Numerous activities require an individual to respond quickly to the correct stimulus. The provision of advance information allows response priming but heightened responses can cause errors (responding too early or reacting to the wrong stimulus). Thus, a balance is required between the online cognitive mechanisms (inhibitory and anticipatory) used to prepare and execute a motor response at the appropriate time. We investigated the use of advance information in 71 participants across four different age groups: (i) children, (ii) young adults, (iii) middle-aged adults, and (iv) older adults. We implemented 'cued' and 'non-cued' conditions to assess age-related changes in saccadic and touch responses to targets in three movement conditions: (a) Eyes only; (b) Hands only; (c) Eyes and Hand. Children made less saccade errors compared to young adults, but they also exhibited longer response times in cued versus non-cued conditions. In contrast, older adults showed faster responses in cued conditions but exhibited more errors. The results indicate that young adults (18 -25 years) achieve an optimal balance between anticipation and execution. In contrast, children show benefits (few errors) and costs (slow responses) of good inhibition when preparing a motor response based on advance information; whilst older adults show the benefits and costs associated with a prospective response strategy (i.e., good anticipation)

Antibodies Against Glycolipids Enhance Antifungal Activity of Macrophages and Reduce Fungal Burden After Infection with Paracoccidioides brasiliensis

Paracoccidioidomycosis is a fungal disease endemic in Latin America. Polyclonal antibodies to acidic glycosphingolipids (GSLs) from Paracoccidioides brasiliensis opsonized yeast forms in vitro increasing phagocytosis and reduced the fungal burden of infected animals. Antibodies to GSL were active in both prophylactic and therapeutic protocols using a murine intratracheal infection model. Pathological examination of the lungs of animals treated with antibodies to GSL showed well-organized granulomas and minimally damaged parenchyma compared to the untreated control. Murine peritoneal macrophages activated by IFN-gamma and incubated with antibodies against acidic GSLs more effectively phagocytosed and killed P brasiliensis yeast cells as well as produced more nitric oxide compared to controls. The present work discloses a novel target of protective antibodies against P brasiliensis adding to other well-studied mediators of the immune response to this fungus.CapesFAPESPUniv Sao Paulo, Dept Microbiol, Inst Biomed Sci, Sao Paulo, BrazilUniv Sao Paulo, Lab Med Mycol IMTSP LIM53, Sao Paulo, BrazilAlbert Einstein Coll Med, Dept Med, New York, NY USAAlbert Einstein Coll Med, Dept Microbiol & Immunol, New York, NY USAUniv Fed Fluminense, Niteroi, RJ, BrazilUniv Fed Sao Paulo, Dept Microbiol Immunol & Parasitol, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Microbiol Immunol & Parasitol, Sao Paulo, BrazilFAPESP: 2011/17267-4FAPESP: 2013/18655-3Web of Scienc

Produção de aveia-preta com solução nutritiva e adição de substâncias húmicas

O experimento foi realizado no ano de 1 997, em casa de vegetação, na Faculdade de Agronomia da Universidade Federal do Rio Grande do Sul (UFRGS), utilizando o desenho experimentai de blocos casualizados em parcelas subdivididas com seis repetições. A aveia foi cultivada em areia irrigada, com solução nutritiva completa e quatro doses (0, 10, 20 e 30 mg.L·') de substâncias húmicas, extraídas a partir dos carvões das minas do Capané (Pai ermo CE-4.200 e Palerma CE-4.700), Leão (Leão CE-5.200) e Candiota (Candiota Camada Superior, Candiota Camada Superior, Candiota CE-3.300 e Candiota CE-4.700). Foram avaliadas as seguintes variáveis: matéria seca produzida pela parte aérea e pelas raízes, comprimento das raízes, raio médio das raízes e superfície ocupada pelas raízes. A utilização das tas substâncias aumentou em até 21,88% a produção de matéria seca da parte aérea; em até 1 09,2% o comprimento das raízes e em até 46,69% a superfície ocupada pelas raízes. Os resultados obtidos indicaram que as substâncias húmicas influenciaram o desenvolvimento da parte aérea e das raízes da aveia, e que as substâncias húmicas originadas de diversos carvões atuaram de forma diferente sobre os parâmetros das cinco variáveis analisadas.a split-plot experimental design with treatments arranged in randomized complete blocks, with six repl ications. Black Oats forage was grown in pots with irrigated sartd and four leveis (0, 1 0, 20 and 30 mg.L-1) of humic compounds added to a complete nutrient solution. Humic substances were extracted from Capané (Palerma coais EC-4,200 and EC-4,700), Candiota (Candiota coais superior layer, inferior layer, EC-3,300 and EC- 4,700) and Leão (Leão coai EC-5,200). Aerial part dry matter yield, length of roots, mean radi um o f roots, occupied roots surface and dry matter yield o f rootswere evaluated. Results showed that humic compounds influenced oats roots growing increasing mainly: aerial part dry matter yield in 2 1 ,88%; root length in 1 09,2%; occupied root surface in 46,69%. It is concluded that humic compounds affected black oats roots development. Humic compounds from different raw materiais influenced diversely the five variables that were evaluated