5,113 research outputs found
Recommended from our members
The role of HG in the analysis of temporal iteration and interaural correlation
Tackling Radicalisation: The Limitations of the Anti-Radicalisation Prevent Duty
This is the author accepted manuscript. the final version is available via Westlaw UKThe past decade has seen the rise of a new threat, a state’s own radicalised citizens
committing terrorist atrocities for a global cause. To respond to this threat, successive
UK governments have introduced Prevent strategies in an attempt to counter the
factors that lead to radicalisation. In 2015 the Coalition Government went further,
introducing a specific legal duty (s 26(1) Counter-Terrorism and Security Act 2015).
This duty requires specified authorities to have due regard to the need to prevent
people from being drawn into terrorism. This article explores the requirements of the
duty and its compatibility with the ECHR. Overall it is argued that rather than building
on the Prevent strategies, the Prevent Duty has both accentuated the limitations of the
strategies, while at the same time also creating new problems, both of which are likely
to prove counter-productive and thus ultimately undermine the UK’s ability to prevent
terrorism
Analysis of Mono-, Di- and Oligosaccharides by CE Using a Two-Stage Derivatization Method and LIF Detection.
A sensitive CE with LIF method has been developed for quantitative analysis of small carbohydrates. In this work, 17 carbohydrates including mono-, di- and oligosaccharides
were simultaneously derivatized with 4-fluoro 7-nitrobenzo furazane (NBD-F) via a twostep reaction involving reductive amination with ammonia followed by condensation with NBD-F. Under the optimized derivatization conditions all carbo-hydrates were successfully derivatized within 2.5 h and separated within 15 min using borate buffer (90 mmol/L, pH 9.2). For sugar standards LODs were in the range of 49.7 to
243.6 nmol/L. Migration time and peak area reproducibility were better than RSD 0.1 and 3%, respectively. The method was applied to measure sugars in nanoliter volume samples of phloem sap obtained by stylectomy from wheat and to honeydew samples obtained from aphids feeding from wheat and willow
The importance of regulators and inspectorates to the realisation of equality and human rights: Ensuring compliance and supporting mainstreaming
This is the author accepted manuscript. The final version is available online on Westlaw U
Discrete structures in gravity
Discrete approaches to gravity, both classical and quantum, are reviewed
briefly, with emphasis on the method using piecewise-linear spaces. Models of
3-dimensional quantum gravity involving 6j-symbols are then described, and
progress in generalising these models to four dimensions is discussed, as is
the relationship of these models in both three and four dimensions to
topological theories. Finally, the repercussions of the generalisations are
explored for the original formulation of discrete gravity using edge-length
variables.Comment: 30 pages, 4 figure
A unitary correlation operator method
The short range repulsion between nucleons is treated by a unitary
correlation operator which shifts the nucleons away from each other whenever
their uncorrelated positions are within the replusive core. By formulating the
correlation as a transformation of the relative distance between particle
pairs, general analytic expressions for the correlated wave functions and
correlated operators are given. The decomposition of correlated operators into
irreducible n-body operators is discussed. The one- and two-body-irreducible
parts are worked out explicitly and the contribution of three-body correlations
is estimated to check convergence. Ground state energies of nuclei up to mass
number A=48 are calculated with a spin-isospin-dependent potential and single
Slater determinants as uncorrelated states. They show that the deduced energy-
and mass-number-independent correlated two-body Hamiltonian reproduces all
"exact" many-body calculations surprisingly well.Comment: 43 pages, several postscript figures, uses 'epsfig.cls'. Submitted to
Nucl. Phys. A. More information available at http://www.gsi.de/~fm
Fish oil omega-3 fatty acids partially prevent lipid-induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulation
This is the author accepted manuscript. The final version is available from Portland Press via the DOI in this record Acylcarnitine accumulation in skeletal muscle and plasma has been observed in numerous models of mitochondrial lipid overload and insulin resistance. Fish oil n3PUFA (omega-3 polyunsaturated fatty acids) are thought to protect against lipid-induced insulin resistance. The present study tested the hypothesis that the addition of n3PUFA to an intravenous lipid emulsion would limit muscle acylcarnitine accumulation and reduce the inhibitory effect of lipid overload on insulin action. On three occasions, six healthy young men underwent a 6-h euglycaemic-hyperinsulinaemic clamp accompanied by intravenous infusion of saline (Control), 10% Intralipid® [n6PUFA (omega-6 polyunsaturated fatty acids)] or 10% Intralipid®+10% Omegaven® (2:1; n3PUFA). The decline in insulin-stimulated whole-body glucose infusion rate, muscle PDCa (pyruvate dehydrogenase complex activation) and glycogen storage associated with n6PUFA compared with Control was prevented with n3PUFA. Muscle acetyl-CoA accumulation was greater following n6PUFA compared with Control and n3PUFA, suggesting that mitochondrial lipid overload was responsible for the lower insulin action observed. Despite these favourable metabolic effects of n3PUFA, accumulation of total muscle acylcarnitine was not attenuated when compared with n6PUFA. These findings demonstrate that n3PUFA exert beneficial effects on insulin-stimulated skeletal muscle glucose storage and oxidation independently of total acylcarnitine accumulation, which does not always reflect mitochondrial lipid overload.This research study was funded by The Royal Society [Grant RG100575]
Recommended from our members
A randomised controlled trial of cognitive behavioural treatment for obsessive compulsive disorder in children and adolescents
Cognitive behaviour therapy (CBT) for young people with obsessive compulsive disorder (OCD) has become the treatment of first choice. However, the literature is largely based on studies emphasising exposure and response prevention. In this study, we report on a randomised controlled trial of CBT for young people carried out in typical outpatient clinic conditions which focused on cognitions. A randomised controlled trial compares 10 sessions of manualised cognitive behavioural treatment with a 12-week waiting list for adolescents and children with OCD. Assessors were blind to treatment allocation. 21 consecutive patients with OCD aged between 9 and 18 years were recruited. The group who received treatment improved more than a comparison group who waited for 3 months. The second group was treated subsequently using the same protocol and made similar gains. In conclusion, CBT can be delivered effectively to young people with OCD in typical outpatient settings
- …