719 research outputs found

    Popular Matchings in the Capacitated House Allocation Problem

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    We consider the problem of finding a popular matching in the Capacitated House Allocation problem (CHA). An instance of CHA involves a set of agents and a set of houses. Each agent has a preference list in which a subset of houses are ranked in strict order, and each house may be matched to a number of agents that must not exceed its capacity. A matching M is popular if there is no other matching M′ such that the number of agents who prefer their allocation in M′ to that in M exceeds the number of agents who prefer their allocation in M to that in M′. Here, we give an O(√C+n1m) algorithm to determine if an instance of CHA admits a popular matching, and if so, to find a largest such matching, where C is the total capacity of the houses, n1 is the number of agents and m is the total length of the agents’ preference lists. For the case where preference lists may contain ties, we give an O(√Cn1+m) algorithm for the analogous problem

    The Hospitals/Residents Problem with Couples: complexity and integer programming models

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    The Hospitals / Residents problem with Couples (hrc) is a generalisation of the classical Hospitals / Residents problem (hr) that is important in practical applications because it models the case where couples submit joint preference lists over pairs of (typically geographically close) hospitals. In this paper we give a new NP-completeness result for the problem of deciding whether a stable matching exists, in highly restricted instances of hrc, and also an inapproximability bound for finding a matching with the minimum number of blocking pairs in equally restricted instances of hrc. Further, we present a full description of the first Integer Programming model for finding a maximum cardinality stable matching in an instance of hrc and we describe empirical results when this model applied to randomly generated instances of hrc

    Quantum phases of atomic boson-fermion mixtures in optical lattices

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    The zero-temperature phase diagram of a binary mixture of bosonic and fermionic atoms in an one-dimensional optical lattice is studied in the framework of the Bose-Fermi-Hubbard model. By exact numerical solution of the associated eigenvalue problems, ground state observables and the response to an external phase twist are evaluated. The stiffnesses under phase variations provide measures for the boson superfluid fraction and the fermionic Drude weight. Several distinct quantum phases are identified as function of the strength of the repulsive boson-boson and the boson-fermion interaction. Besides the bosonic Mott-insulator phase, two other insulating phases are found, where both the bosonic superfluid fraction and the fermionic Drude weight vanish simultaneously. One of these double-insulator phases exhibits a crystalline diagonal long-range order, while the other is characterized by spatial separation of the two species.Comment: 4 pages, 3 figures, using REVTEX

    Changes in epidemiological patterns of sea lice infestation on farmed Atlantic salmon, Salmo salar L., in Scotland between 1996 and 2006

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    Analyses of a unique database containing sea lice records over an 11 year period provide evidence of changing infestation patterns in Scotland. The data, collected from more than 50 commercial Atlantic salmon farms, indicate that both species of sea lice commonly found in Scotland, Lepeophtheirus salmonis and Caligus elongatus, have declined on farms over the past decade. Reductions for both species have been particularly marked since 2001 when more effective veterinary medicines became available. Treatment data were also available in the database and these show a growing trend towards the use of the in feed medication emamectin benzoate (Slice), particularly in the first year of the salmon production cycle. However, this trend to wards single product use has not been sustained in 2006, the latest year for which data are available. There is some evidence of region to region variation within Scotland with the Western Isles experiencing higher levels of infestation. However, compared to the levels observed between 1996 and 2000, all regions have benefited from reduced lice infestation, with the overall pattern showing a particular reduction in the second and third quarters of the second year of production

    G-protein-coupled receptors at a glance

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    Popular matchings in the marriage and roommates problems

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    Popular matchings have recently been a subject of study in the context of the so-called House Allocation Problem, where the objective is to match applicants to houses over which the applicants have preferences. A matching M is called popular if there is no other matching M′ with the property that more applicants prefer their allocation in M′ to their allocation in M. In this paper we study popular matchings in the context of the Roommates Problem, including its special (bipartite) case, the Marriage Problem. We investigate the relationship between popularity and stability, and describe efficient algorithms to test a matching for popularity in these settings. We also show that, when ties are permitted in the preferences, it is NP-hard to determine whether a popular matching exists in both the Roommates and Marriage cases

    Deterministic delivery of externally cold and precisely positioned single molecular ions

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    We present the preparation and deterministic delivery of a selectable number of externally cold molecular ions. A laser cooled ensemble of Mg^+ ions subsequently confined in several linear Paul traps inter-connected via a quadrupole guide serves as a cold bath for a single or up to a few hundred molecular ions. Sympathetic cooling embeds the molecular ions in the crystalline structure. MgH^+ ions, that serve as a model system for a large variety of other possible molecular ions, are cooled down close to the Doppler limit and are positioned with an accuracy of one micrometer. After the production process, severely compromising the vacuum conditions, the molecular ion is efficiently transfered into nearly background-free environment. The transfer of a molecular ion between different traps as well as the control of the molecular ions in the traps is demonstrated. Schemes, optimized for the transfer of a specific number of ions, are realized and their efficiencies are evaluated. This versatile source applicable for broad charge-to-mass ratios of externally cold and precisely positioned molecular ions can serve as a container-free target preparation device well suited for diffraction or spectroscopic measurements on individual molecular ions at high repetition rates (kHz).Comment: 11 pages, 8 figure

    Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Gαq-coupled protein receptors

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    5-Hydroxytryptamine 2A (5-HT2A) serotonin receptors are important for a variety of functions including vascular smooth muscle contraction, platelet aggregation, and the modulation of perception, cognition, and emotion. In a search for 5-HT2A receptor-interacting proteins, we discovered that caveolin-1 (Cav-1), a scaffolding protein enriched in caveolae, complexes with 5-HT2A receptors in a number of cell types including C6 glioma cells, transfected HEK-293 cells, and rat brain synaptic membrane preparations. To address the functional significance of this interaction, we performed RNA interference-mediated knockdown of Cav-1 in C6 glioma cells, a cell type that endogenously expresses both 5-HT2A receptors and Cav-1. We discovered that the in vitro knockdown of Cav-1 in C6 glioma cells nearly abolished 5-HT2A receptor-mediated signal transduction as measured by calcium flux assays. RNA interference-mediated knockdown of Cav-1 also greatly attenuated endogenous Gαq-coupled P2Y purinergic receptor-mediated signaling without altering the signaling of PAR-1 thrombin receptors. Cav-1 appeared to modulate 5-HT2A signaling by facilitating the interaction of 5-HT2A receptors with Gαq. These studies provide compelling evidence for a prominent role of Cav-1 in regulating the functional activity of not only 5-HT 2A serotonin receptors but also selected Gαq-coupled receptors

    Nanoscale Processing by Adaptive Laser Pulses

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    We theoretically demonstrate that atomically-precise ``nanoscale processing" can be reproducibly performed by adaptive laser pulses. We present the new approach on the controlled welding of crossed carbon nanotubes, giving various metastable junctions of interest. Adaptive laser pulses could be also used in preparation of other hybrid nanostructures.Comment: 4 pages, 4 Postscript figure
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