9 research outputs found
Fracture behaviour of notched round bars made of PMMA subjected to torsion at -60 °C
This paper presents seventy new experimental results from PMMA notched specimens
tested under torsion at 60 C. The notch root radius ranges from 0.025 to 7.0 mm. At this
temperature the non-linear effects previously observed on specimens of the same material
tested at room temperature strongly reduce.
The averaged value of the strain energy density over a control volume is used to assess
the critical loads to failure. The radius of the control volume and the critical strain energy
density are evaluated a priori by using in combination the mode III critical stress intensity
factor from cracked-like specimens and the critical stress to failure detected from semicircular
notches with a large notch root radiu
On the Ability of the Equivalent Material Concept in Predicting Ductile Failure of U-Notches under Moderate- and Large-Scale Yielding Conditions
Crack Initiation at V-Notch Tip under In-Plane Mixed Mode Loading: A Review of the Fictitious Notch Rounding Concept
Elastic-plastic fracture analysis of notched Al 7075-T6 plates by means of the local energy combined with the equivalent material concept
Mixed mode I/II brittle fracture in V-notched Brazilian disk specimens under negative mode I conditions
Evaluation of Nutritional Practices in the Critical Care patient (The ENPIC study) : Does nutrition really affect ICU mortality?
The importance of artificial nutritional therapy is underrecognized, typically being considered an adjunctive rather than a primary therapy. We aimed to evaluate the influence of nutritional therapy on mortality in critically ill patients. Methods: This multicenter prospective observational study included adult patients needing artificial nutritional therapy for >48 h if they stayed in one of 38 participating intensive care units for ≥72 h between April and July 2018. Demographic data, comorbidities, diagnoses, nutritional status and therapy (type and details for ≤14 days), and outcomes were registered in a database. Confounders such as disease severity, patient type (e.g., medical, surgical or trauma), and type and duration of nutritional therapy were also included in a multivariate analysis, and hazard ratios (HRs) and 95% confidence intervals (95%CIs) were reported. We included 639 patients among whom 448 (70.1%) and 191 (29.9%) received enteral and parenteral nutrition, respectively. Mortality was 25.6%, with non-survivors having the following characteristics: older age; more comorbidities; higher Sequential Organ Failure Assessment (SOFA) scores (6.6 ± 3.3 vs 8.4 ± 3.7; P < 0.001); greater nutritional risk (Nutrition Risk in the Critically Ill [NUTRIC] score: 3.8 ± 2.1 vs 5.2 ± 1.7; P < 0.001); more vasopressor requirements (70.4% vs 83.5%; P=0.001); and more renal replacement therapy (12.2% vs 23.2%; P=0.001). Multivariate analysis showed that older age (HR: 1.023; 95% CI: 1.008-1.038; P=0.003), higher SOFA score (HR: 1.096; 95% CI: 1.036-1.160; P=0.001), higher NUTRIC score (HR: 1.136; 95% CI: 1.025-1.259; P=0.015), requiring parenteral nutrition after starting enteral nutrition (HR: 2.368; 95% CI: 1.168-4.798; P=0.017), and a higher mean Kcal/Kg/day intake (HR: 1.057; 95% CI: 1.015-1.101; P=0.008) were associated with mortality. By contrast, a higher mean protein intake protected against mortality (HR: 0.507; 95% CI: 0.263-0.977; P=0.042). Old age, higher organ failure scores, and greater nutritional risk appear to be associated with higher mortality. Patients who need parenteral nutrition after starting enteral nutrition may represent a high-risk subgroup for mortality due to illness severity and problems receiving appropriate nutritional therapy. Mean calorie and protein delivery also appeared to influence outcomes. ClinicaTrials.gov NCT: 03634943