Integración LDAP con el Servicio PAPI

Sección: SolucionesEl servicio PAPI es el protocolo de autenticación que emplea la Red de Bibliotecas del CSIC para que cualquier usuario de la institución pueda acceder a los recursos electrónicos desde cualquier lugar y a cualquier hora bajo reconocimiento de usuario y contraseña. El objetivo es hacer coincidir las credenciales de acceso al Servicio PAPI con los datos que maneja el Directorio de datos de la Institución y por otro lado integrar casi de forma automática al Servicio PAPI a todas las personas que se integren en la plantilla del CSIC.N

Asymptotic Analysis of Thin Interface in Composite Materials with Coated Boundary

This paper considers the problem of thin interface in a fibre reinforced composite material. Using the singular asymptotic procedure, the authors obtain simplified relations known as spring model. Phenomenon of edge effect is also studied using the Papkovich-Fadle approach. The singularities of the limit problem are analysed

Геоэкологическая оценка объектов водоснабжения поселка Ванавара (Красноярский край)

В работе представлены результаты оценки качества подземных вод нижнетриасового туфогенно-осадочного водоносного комплекса. Данные подземные воды используются для питьевого водоснабжения п. Ванавара. Дана характеристика геологического строения участка, гидрогеологические условия, охарактеризованы геохимические особенности, при которых изменение качественного состава подземных вод происходит в связи с природными процессами. Произведен расчет уровня загрязнения подземных вод под воздействием техногенного воздействия.The paper presents the results of assessing the quality of underground waters of the Lower Triassic tuff-sedimentary aquifer complex. These underground waters are used for drinking water supply in the village of Vanavara. The characteristics of the geological structure of the site, hydrogeological conditions, geochemical features of the territory, in which the change in the qualitative composition of underground water occurs in connection with natural processes, are described. The calculation of the level of pollution of underground water under the influence of man-made impact is made

Lifting the veil of secrecy: maternal and neonatal outcome of oocyte donation pregnancies in Germany

Background: In Germany, performing fertility procedures involving oocyte donation is illegal, as stated by the Embryo Protection Law. Nonetheless, in our clinical routine we attend to a steadily rising number of pregnant women, who have sought oocyte donation abroad. Due to the legal circumstances many women opt to keep the origin of their pregnancy a secret. However, studies have shown, that oocyte donation is an independent risk factor for the development of pregnancy complications, such as preeclampsia. Objective: The aim of this study is to evaluate maternal and neonatal outcomes of oocyte donation pregnancies in three large obstetric care units in Berlin, Germany. Methods: We retrospectively analyzed all available medical data on oocyte donation pregnancies at Charite University hospital, Vivantes Hospital Friedrichshain, and Neukoelln in the German capital. Results: We included 115 oocyte donation (OD) pregnancies in the present study. Our data are based on 62 singleton, 44 twin, 7 triplet, and 2 quadruplet oocyte donation pregnancies. According to our data, oocyte donation pregnancies are associated with a high risk of adverse maternal and fetal outcome, i.e., hypertension in pregnancy, preterm delivery, Cesarean section as mode of delivery, and increased peripartum hemorrhage. Conclusion: Although oocyte donation is prohibited by German law, many couples go abroad to seek reproductive measures using oocyte donation after former treatment options have failed. OD pregnancies are associated with a high risk of preeclampsia, C-section as mode of delivery, and peripartum hemorrhage. Detailed knowledge of the associated risks is of utmost importance to both the patient and the treating physician and midwife

Preliminary measurements of lumbar spine kinematics and stiffness

The purpose of the presented study was the experimental measurement of lumbar spine stiffness and its range of motion. The dependence of torsion moment of lumbar spine segment on deflection of flexion, extension and torsion was observed during experiments. Stiffness of spine segment was determined from measured data. Human lumbar spine was used for verification of the experimental technique. The sample consisted of one lumbar vertebrae composed by five vertebral bodies and four intervertebral discs. All muscles were removed, however all ligaments were preserved. Experiments were ca rried out on the test system MTS 858.2 MiniBionix, where loading by axial force and torsion moment is possible at the same time. Special Modular Bionix Spine Test Fixator, attached to the test system was used for the measurements. Loading was controlled kinematically (gradual turning) by keeping the axial force equal zero. Measurement was timedependent. The results of these experiments are going to be used as input data for creating a model of artificial lumbar spine and new type of artificial disc replacement

Accumulation of specific sterol precursors targets a MAP kinase cascade mediating cell-cell recognition and fusion

Sterols are vital components of eukaryotic cell membranes. Defects in sterol biosynthesis, which result in the accumulation of precursor molecules, are commonly associated with cellular disorders and disease. However, the effects of these sterol precursors on the metabolism, signaling, and behavior of cells are only poorly understood. In this study, we show that the accumulation of only ergosterol precursors with a conjugated double bond in their aliphatic side chain specifically disrupts cell–cell communication and fusion in the fungus Neurospora crassa. Genetically identical germinating spores of this fungus undergo cell–cell fusion, thereby forming a highly interconnected supracellular network during colony initiation. Before fusion, the cells use an unusual signaling mechanism that involves the coordinated and alternating switching between signal sending and receiving states of the two fusion partners. Accumulation of only ergosterol precursors with a conjugated double bond in their aliphatic side chain disrupts this coordinated cell–cell communication and suppresses cell fusion. These specific sterol precursors target a single ERK-like mitogen-activated protein (MAP) kinase (MAK-1)-signaling cascade, whereas a second MAP kinase pathway (MAK-2), which is also involved in cell fusion, is unaffected. These observations indicate that a minor specific change in sterol structure can exert a strong detrimental effect on a key signaling pathway of the cell, resulting in the absence of cell fusion

Wave propagation in periodic composites: higher-order asymptotic analysis versus plane-wave expansion method

This work is devoted to a comparison of different methods determining stop-bands i

Lifting the veil of secrecy: maternal and neonatal outcome of oocyte donation pregnancies in Germany

BACKGROUND: In Germany, performing fertility procedures involving oocyte donation is illegal, as stated by the Embryo Protection Law. Nonetheless, in our clinical routine we attend to a steadily rising number of pregnant women, who have sought oocyte donation abroad. Due to the legal circumstances many women opt to keep the origin of their pregnancy a secret. However, studies have shown, that oocyte donation is an independent risk factor for the development of pregnancy complications, such as preeclampsia. OBJECTIVE: The aim of this study is to evaluate maternal and neonatal outcomes of oocyte donation pregnancies in three large obstetric care units in Berlin, Germany. METHODS: We retrospectively analyzed all available medical data on oocyte donation pregnancies at Charité University hospital, Vivantes Hospital Friedrichshain, and Neukoelln in the German capital. RESULTS: We included 115 oocyte donation (OD) pregnancies in the present study. Our data are based on 62 singleton, 44 twin, 7 triplet, and 2 quadruplet oocyte donation pregnancies. According to our data, oocyte donation pregnancies are associated with a high risk of adverse maternal and fetal outcome, i.e., hypertension in pregnancy, preterm delivery, Cesarean section as mode of delivery, and increased peripartum hemorrhage. CONCLUSION: Although oocyte donation is prohibited by German law, many couples go abroad to seek reproductive measures using oocyte donation after former treatment options have failed. OD pregnancies are associated with a high risk of preeclampsia, C-section as mode of delivery, and peripartum hemorrhage. Detailed knowledge of the associated risks is of utmost importance to both the patient and the treating physician and midwife

Histone deacetylases as new therapy targets for platinum-resistant epithelial ovarian cancer

Introduction: In developed countries, ovarian cancer is the fourth most common cancer in women. Due to the nonspecific symptomatology associated with the disease many patients with ovarian cancer are diagnosed late, which leads to significantly poorer prognosis. Apart from surgery and radiotherapy, a substantial number of ovarian cancer patients will undergo chemotherapy and platinum based agents are the mainstream first-line therapy for this disease. Despite the initial efficacy of these therapies, many women relapse; therefore, strategies for second-line therapies are required. Regulation of DNA transcription is crucial for tumour progression, metastasis and chemoresistance which offers potential for novel drug targets. Methods: We have reviewed the existing literature on the role of histone deacetylases, nuclear enzymes regulating gene transcription. Results and conclusion: Analysis of available data suggests that a signifant proportion of drug resistance stems from abberant gene expression, therefore HDAC inhibitors are amongst the most promising therapeutic targets for cancer treatment. Together with genetic testing, they may have a potential to serve as base for patient-adapted therapies