834 research outputs found
Immunohistological studies on neoplasms of female and male Onchocerca volvulus: filarial origin and absence of Wolbachia from tumor cells
Up to 5% of untreated female Onchocerca volvulus filariae develop potentially fatal pleomorphic neoplasms, whose incidence is increased following ivermectin treatment. We studied the occurrence of 8 filarial proteins and of Wolbachia endobacteria in the tumor cells. Onchocercomas from patients, untreated and treated with antibiotics and anthelminthics, were examined by immunohistology. Neoplasms were diagnosed in 112 of 3587 female and in 2 of 1570 male O. volvulus. The following proteins and other compounds of O. volvulus were expressed in the cells of the neoplasms: glutathione S-transferase 1, lysosomal aspartic protease, cAMP-dependent protein kinase, alpha-enolase, aspartate aminotransferase, ankyrin E1, tropomyosin, heat shock protein 60, transforming growth factor-beta, and prostaglandin E2. These findings prove the filarial origin of the neoplasms and confirm the pleomorphism of the tumor cells. Signs indicating malignancy of the neoplasms are described. Wolbachia were observed in the hypodermis, oocytes, and embryos of tumor-harbouring filariae using antibodies against Wolbachia surface protein, Wolbachia HtrA-type serine protease, and Wolbachia aspartate aminotransferase. In contrast, Wolbachia were not found in the cells of the neoplasms. Further, neoplasm-containing worms were not observed after more than 10 months after the start of sufficient treatment with doxycycline or doxycycline plus ivermectin
Thermodynamics of quantum Brownian motion with internal degrees of freedom: the role of entanglement in the strong-coupling quantum regime
We study the influence of entanglement on the relation between the
statistical entropy of an open quantum system and the heat exchanged with a low
temperature environment. A model of quantum Brownian motion of the
Caldeira-Leggett type - for which a violation of the Clausius inequality has
been stated by Th.M. Nieuwenhuizen and A.E. Allahverdyan [Phys. Rev. E 66,
036102 (2002)] - is reexamined and the results of the cited work are put into
perspective. In order to address the problem from an information theoretical
viewpoint a model of two coupled Brownian oscillators is formulated that can
also be viewed as a continuum version of a two-qubit system. The influence of
an additional internal coupling parameter on heat and entropy changes is
described and the findings are compared to the case of a single Brownian
particle.Comment: 10 pages, 11 figure
The Infrared Behavior of Gluon and Ghost Propagators in Landau Gauge QCD
A solvable systematic truncation scheme for the Dyson-Schwinger equations of
Euclidean QCD in Landau gauge is presented. It implements the Slavnov-Taylor
identities for the three-gluon and ghost-gluon vertices, whereas irreducible
four-gluon couplings as well as the gluon-ghost and ghost-ghost scattering
kernels are neglected. The infrared behavior of gluon and ghost propagators is
obtained analytically: The gluon propagator vanishes for small spacelike
momenta whereas the ghost propagator diverges stronger than a massless particle
pole. The numerical solutions are compared with recent lattice data for these
propagators. The running coupling of the renormalization scheme approaches a
fixed point, , in the infrared.Comment: 4 pages, 2 figures, Revtex; revised version accepted for publication
in Physical Review Letter
Field-free deterministic ultra fast creation of skyrmions by spin orbit torques
Magnetic skyrmions are currently the most promising option to realize
current-driven magnetic shift registers. A variety of concepts to create
skyrmions were proposed and demonstrated. However, none of the reported
experiments show controlled creation of single skyrmions using integrated
designs. Here, we demonstrate that skyrmions can be generated deterministically
on subnanosecond timescales in magnetic racetracks at artificial or natural
defects using spin orbit torque (SOT) pulses. The mechanism is largely similar
to SOT-induced switching of uniformly magnetized elements, but due to the
effect of the Dzyaloshinskii-Moriya interaction (DMI), external fields are not
required. Our observations provide a simple and reliable means for skyrmion
writing that can be readily integrated into racetrack devices
Molecular dynamics of a short range ordered smectic phase nanoconfined into porous silicon
4-n-octyl-4-cyanobiphenyl (8CB) has been recently shown to display an unusual
sequence of phases when confined into porous silicon (PSi). The gradual
increase of oriented short-range smectic (SRS) correlations in place of a phase
transition has been interpreted as a consequence of the anisotropic quenched
disorder induced by confinement in PSi. Combining two quasielastic neutron
scattering experiments with complementary energy resolutions, we present the
first investigation of the individual molecular dynamics of this system. A
large reduction of the molecular dynamics is observed in the confined liquid
phase, as a direct consequence of the dynamical boundary conditions imposed by
the confinement. Temperature fixed window scans (FWS) reveal a continuous
'glass-like' reduction of the molecular dynamics of the confined liquid and SRS
phases on cooling down to 250 K, where a solid-like behavior is finally reached
by a two steps crystallization process
Isolation of quiescent and nonquiescent cells from yeast stationary-phase cultures
Quiescence is the most common and, arguably, most poorly understood cell cycle state. This is in part because pure populations of quiescent cells are typically difficult to isolate. We report the isolation and characterization of quiescent and nonquiescent cells from stationary-phase (SP) yeast cultures by density-gradient centrifugation. Quiescent cells are dense, unbudded daughter cells formed after glucose exhaustion. They synchronously reenter the mitotic cell cycle, suggesting that they are in a G0 state. Nonquiescent cells are less dense, heterogeneous, and composed of replicatively older, asynchronous cells that rapidly lose the ability to reproduce. Microscopic and flow cytometric analysis revealed that nonquiescent cells accumulate more reactive oxygen species than quiescent cells, and over 21 d, about half exhibit signs of apoptosis and necrosis. The ability to isolate both quiescent and nonquiescent yeast cells from SP cultures provides a novel, tractable experimental system for studies of quiescence, chronological and replicative aging, apoptosis, and the cell cycle
Analyticity and Minimality of Nonperturbative Contributions in Perturbative region for
It is shown, that the possibility of a freezing of QCD running coupling
constant at zero in the approach with "forced analyticity" can not be in accord
with Schwinger-Dyson equation for gluon propagator. We propose to add to the
analytic expression the well-known infrared singular term as well as
pole term corresponding to "excited gluon". With this example we formulate the
principle of minimality of nonperturbative contributions in perturbative
(ultraviolet) region, which allows us to fix ambiguities in introduction of
nonperturbative terms and maintain the finiteness of the gluon condensate. As a
result we obtain estimates of the gluon condensate, which quite agree with
existing data. The nonzero effective mass of the "excited gluon" leads also to
some interesting qualitative consequences.Comment: 11 pages, LATEX, 1 Table (calculation of gluon condensate corrected,
Table extended
Skyrmion Hall Effect Revealed by Direct Time-Resolved X-Ray Microscopy
Magnetic skyrmions are highly promising candidates for future spintronic
applications such as skyrmion racetrack memories and logic devices. They
exhibit exotic and complex dynamics governed by topology and are less
influenced by defects, such as edge roughness, than conventionally used domain
walls. In particular, their finite topological charge leads to a predicted
"skyrmion Hall effect", in which current-driven skyrmions acquire a transverse
velocity component analogous to charged particles in the conventional Hall
effect. Here, we present nanoscale pump-probe imaging that for the first time
reveals the real-time dynamics of skyrmions driven by current-induced spin
orbit torque (SOT). We find that skyrmions move at a well-defined angle
{\Theta}_{SH} that can exceed 30{\deg} with respect to the current flow, but in
contrast to theoretical expectations, {\Theta}_{SH} increases linearly with
velocity up to at least 100 m/s. We explain our observation based on internal
mode excitations in combination with a field-like SOT, showing that one must go
beyond the usual rigid skyrmion description to unravel the dynamics.Comment: pdf document arxiv_v1.1. 24 pages (incl. 9 figures and supplementary
information
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