Impact of primary kidney disease on the effects of empagliflozin in patients with chronic kidney disease: secondary analyses of the EMPA-KIDNEY trial

Background: The EMPA KIDNEY trial showed that empagliflozin reduced the risk of the primary composite outcome of kidney disease progression or cardiovascular death in patients with chronic kidney disease mainly through slowing progression. We aimed to assess how effects of empagliflozin might differ by primary kidney disease across its broad population. Methods: EMPA-KIDNEY, a randomised, controlled, phase 3 trial, was conducted at 241 centres in eight countries (Canada, China, Germany, Italy, Japan, Malaysia, the UK, and the USA). Patients were eligible if their estimated glomerular filtration rate (eGFR) was 20 to less than 45 mL/min per 1·73 m2, or 45 to less than 90 mL/min per 1·73 m2 with a urinary albumin-to-creatinine ratio (uACR) of 200 mg/g or higher at screening. They were randomly assigned (1:1) to 10 mg oral empagliflozin once daily or matching placebo. Effects on kidney disease progression (defined as a sustained ≥40% eGFR decline from randomisation, end-stage kidney disease, a sustained eGFR below 10 mL/min per 1·73 m2, or death from kidney failure) were assessed using prespecified Cox models, and eGFR slope analyses used shared parameter models. Subgroup comparisons were performed by including relevant interaction terms in models. EMPA-KIDNEY is registered with ClinicalTrials.gov, NCT03594110. Findings: Between May 15, 2019, and April 16, 2021, 6609 participants were randomly assigned and followed up for a median of 2·0 years (IQR 1·5–2·4). Prespecified subgroupings by primary kidney disease included 2057 (31·1%) participants with diabetic kidney disease, 1669 (25·3%) with glomerular disease, 1445 (21·9%) with hypertensive or renovascular disease, and 1438 (21·8%) with other or unknown causes. Kidney disease progression occurred in 384 (11·6%) of 3304 patients in the empagliflozin group and 504 (15·2%) of 3305 patients in the placebo group (hazard ratio 0·71 [95% CI 0·62–0·81]), with no evidence that the relative effect size varied significantly by primary kidney disease (pheterogeneity=0·62). The between-group difference in chronic eGFR slopes (ie, from 2 months to final follow-up) was 1·37 mL/min per 1·73 m2 per year (95% CI 1·16–1·59), representing a 50% (42–58) reduction in the rate of chronic eGFR decline. This relative effect of empagliflozin on chronic eGFR slope was similar in analyses by different primary kidney diseases, including in explorations by type of glomerular disease and diabetes (p values for heterogeneity all >0·1). Interpretation: In a broad range of patients with chronic kidney disease at risk of progression, including a wide range of non-diabetic causes of chronic kidney disease, empagliflozin reduced risk of kidney disease progression. Relative effect sizes were broadly similar irrespective of the cause of primary kidney disease, suggesting that SGLT2 inhibitors should be part of a standard of care to minimise risk of kidney failure in chronic kidney disease. Funding: Boehringer Ingelheim, Eli Lilly, and UK Medical Research Council

Some remarks on a family of T-designs

In a (2m-2) - (4m-1, 2m, m) design there can be no repeated blocks, every two blocks have at least two points in common, and no two blocks can have more than 2m-2 points in common

On the non-existence of 5-(24,12,6) and 4-(23,11,6) designs

It is shown that 5-(24,12,6) and 4-(23,11,6) designs cannot exist and that consequently a non-trivial 2-(2n+1,n,n-1) design can be extended to a 4-(2n+3,n+2,n-1) design if and only if n=4

The transitive 3-(12,6,4) and 2-(11,5,4) designs

The automorphism groups of each of the eight transitive 3-(12,6,4) designs and the three transitive 2-(11,5,4) designs are described. Repeated blocks are allowed in the designs

Irreducible designs from supplementary difference sets

A family of n k-subsets of the integers modulo ν are said to be supplementary difference sets if developing them by addition modulo ν leads to a balanced incomplete block design, and to be minimal if no proper subfamily leads to a balanced incomplete block design when developed modulo ν. In other words, the family of supplementary difference sets is minimal precisely when it leads to a balanced incomplete block design which cannot be partitioned into a union of proper subdesigns, each consisting of complete cyclic sets of ν blocks. We discuss the conditions under which such a balanced incomplete block design can be partitioned in some non-cyclic fashion into a union of proper subdesigns