Bound state approach to the QCD coupling at low energy scales

We exploit theoretical results on the meson spectrum within the framework of a Bethe-Salpeter (BS) formalism adjusted for QCD, in order to extract an ``experimental'' coupling \alpha_s^{exp}(Q^2) below 1 GeV by comparison with the data. Our results for \alpha_s^{exp}(Q^2) exhibit a good agreement with the infrared safe Analytic Perturbation Theory (APT) coupling from 1 GeV down to 200 MeV. As a main result, we claim that the combined BS-APT theoretical scheme provides us with a rather satisfactory correlated understanding of very high and low energy phenomena.Comment: Revised version, to appear on Physical Review Letters. 7 pages, 2 figures, Revte

QCD coupling below 1 GeV from quarkonium spectrum

In this paper we extend the work synthetically presented in Ref.[1] and give theoretical details and complete tables of numerical results. We exploit calculations within a Bethe-Salpeter (BS) formalism adjusted for QCD, in order to extract an ``experimental'' strong coupling \alpha_s^{exp}(Q^2) below 1 GeV by comparison with the meson spectrum. The BS potential follows from a proper ansatz on the Wilson loop to encode confinement and is the sum of a one-gluon-exchange and a confinement terms. Besides, the common perturbative strong coupling is replaced by the ghost-free expression \alpha_E(Q^2) according to the prescription of Analytic Perturbation Theory (APT). The agreement of \alpha_s^{exp}(Q^2) with the APT coupling \alpha_E(Q^2) turns out to be reasonable from 1 GeV down to the 200 MeV scale, thus confirming quantitatively the validity of the APT prescription. Below this scale, the experimental points could give a hint on the vanishing of \alpha_s(Q^2) as Q approaches zero. This infrared behaviour would be consistent with some lattice results and a ``massive'' generalization of the APT approach. As a main result, we claim that the combined BS-APT theoretical scheme provides us with a rather satisfactory correlated understanding of very high and rather low energy phenomena from few hundreds MeV to few hundreds GeV.Comment: Preliminary revision. Typos corrected, comments and references adde

The momentum distribution of J/psi in B decays

The discrepancy between theory and data in the momentum distribution of slow J/psi in B decays has been several times addressed as a puzzle. Using the most recent results on exclusive B decays into J/psi and heavy kaons or exotic mesons and reconsidering the non-relativistic-QCD calculation of the color octet fragmentation component, we show that an improvement in the comparison between data and theory can be obtained. There is still room for a better fit to data and this may imply that new exotic mesons of the XYZ kind have yet to be discovered.Comment: 4 pages, 2 figures, 2 tables. To appear in Physical Review

A novel integral representation for the Adler function

New integral representations for the Adler D-function and the R-ratio of the electron-positron annihilation into hadrons are derived in the general framework of the analytic approach to QCD. These representations capture the nonperturbative information encoded in the dispersion relation for the D-function, the effects due to the interrelation between spacelike and timelike domains, and the effects due to the nonvanishing pion mass. The latter plays a crucial role in this analysis, forcing the Adler function to vanish in the infrared limit. Within the developed approach the D-function is calculated by employing its perturbative approximation as the only additional input. The obtained result is found to be in reasonable agreement with the experimental prediction for the Adler function in the entire range of momenta $0 \le Q^2 < \infty$.Comment: 11 pages, 3 figure

Investigating pseudoscalar and scalar dark matter

In this paper another class of Dark Matter candidate particles: the pseudoscalar and scalar light bosonic candidates, is discussed. Particular care is devoted to the study of the processes for their detection (which only involves electrons and photons/X-rays) in a suitable underground experimental set-up. For this purpose the needed calculations are developed and various related aspects and phenomenologies are discussed. In particular, it is shown that - in addition to the WIMP cases already discussed elsewhere - there is also possibility for a bosonic candidate to account for the 6.3 sigma C.L. model independent evidence for the presence of a particle DM component in the galactic halo observed by DAMA/NaI. Allowed regions in these scenarios are presented also paying particular care on the cosmological interest of the bosonic candidate.Comment: 23 pages, 6 figures, 1 table, Int. J. Mod. Phys. A (in press

APC loss in breast cancer leads to doxorubicin resistance via STAT3 activation

Resistance to chemotherapy is one of the leading causes of death from breast cancer. We recently established that loss of Adenomatous Polyposis Coli (APC) in the Mouse Mammary Tumor Virus – Polyoma middle T (MMTV-PyMT) transgenic mouse model results in resistance to cisplatin or doxorubicin-induced apoptosis. Herein, we aim to establish the mechanism that is responsible for APC-mediated chemotherapeutic resistance. Our data demonstrate that MMTV-PyMT;ApcMin/+ cells have increased signal transducer and activator of transcription 3 (STAT3) activation. STAT3 can be constitutively activated in breast cancer, maintains the tumor initiating cell (TIC) population, and upregulates multidrug resistance protein 1 (MDR1). The activation of STAT3 in the MMTV-PyMT;ApcMin/+ model is independent of interleukin 6 (IL-6); however, enhanced EGFR expression in the MMTV-PyMT;ApcMin/+ cells may be responsible for the increased STAT3 activation. Inhibiting STAT3 with a small molecule inhibitor A69 in combination with doxorubicin, but not cisplatin, restores drug sensitivity. A69 also decreases doxorubicin enhanced MDR1 gene expression and the TIC population enhanced by loss of APC. In summary, these results have revealed the molecular mechanisms of APC loss in breast cancer that can guide future treatment plans to counteract chemotherapeutic resistance

Polarization Asymmetry In The Photodisintegration Of The Deuteron

The reaction ²(γ,p)n has been studied using a monochromatic and polarized gamma ray beam at energies E(γ)=19.8, 29.0, 38.6, and 60.8 MeV. The beam of an intensity ∼4×10⁵ γ/sec was obtained by Compton back scattering of mode-locked laser light off electron bunches in the Adone storage ring. Photoneutron yields were measured at nine neutron angles thetan≃15, 30, 45, 60, 90, 120, 135, 150, and 165 deg in the center of mass (c.m.) for E(γ)=19.8, 29.0, and 38.6 MeV, and at thetan≃30, 60, 90, 120, and 150 deg c.m. for E(γ)=60.8 MeV. The polarization independent component Iₒ(theta) of the differential cross section and the polarization dependent component PI₁(theta) were deduced and the angular distribution of the azimuthal asymmetry factor Σ(theta)=I₁(theta)/Iₒ(theta) was obtained. An extensive comparison with theory has been carried out and the inclusion of corrections due to meson exchange currents and to Δ-isobar configurations have been shown to be mandatory at energies E(γ)≳40 MeV. Theoretical and experimental implications of intermediate energy deuteron photo- disintegration studies are discussed in some detail