Probing Λ\LambdaCDM cosmology with the Evolutionary Map of the Universe survey

The Evolutionary Map of the Universe (EMU) is an all-sky survey in radio-continuum which uses the Australian SKA Pathfinder (ASKAP). Using galaxy angular power spectrum and the integrated Sachs-Wolfe effect, we study the potential of EMU to constrain models beyond $\Lambda$CDM (i.e., local primordial non-Gaussianity, dynamical dark energy, spatial curvature and deviations from general relativity), for different design sensitivities. We also include a multi-tracer analysis, distinguishing between star-forming galaxies and galaxies with an active galactic nucleus, to further improve EMU's potential. We find that EMU could measure the dark energy equation of state parameters around 35\% more precisely than existing constraints, and that the constraints on $f_{\rm NL}$ and modified gravity parameters will improve up to a factor $\sim2$ with respect to Planck and redshift space distortions measurements. With this work we demonstrate the promising potential of EMU to contribute to our understanding of the Universe.Comment: 15 pages (29 with references and appendices), 6 figures and 10 tables. Matches the published version. Minimal changes from previous versio

Delirium in the intensive care unit

Delirium, an acute and fluctuating disturbance of consciousness and cognition, is a common manifestation of acute brain dysfunction in critically ill patients, occurring in up to 80% of the sickest intensive care unit (ICU) populations. Critically ill patients are subject to numerous risk factors for delirium. Some of these, such as exposure to sedative and analgesic medications, may be modified to reduce risk. Although dysfunction of other organ systems continues to receive more clinical attention, delirium is now recognized to be a significant contributor to morbidity and mortality in the ICU, and it is recommended that all ICU patients be monitored using a validated delirium assessment instrument. Patients with delirium have longer hospital stays and lower 6-month survival than do patients without delirium, and preliminary research suggests that delirium may be associated with cognitive impairment that persists months to years after discharge. Little evidence exists regarding the prevention and treatment of delirium in the ICU, but multicomponent interventions reduce the incidence of delirium in non-ICU studies. Strategies for the prevention and treatment of ICU delirium are the subjects of multiple ongoing investigations

5D seismic data completion and denoising using a novel class of tensor decompositions

We have developed a novel strategy for simultaneous interpolation and denoising of prestack seismic data. Most seismic surveys fail to cover all possible source-receiver combinations, leading to missing data especially in the midpoint-offset domain. This undersampling can complicate certain data processing steps such as amplitude-variation-with-offset analysis and migration. Data interpolation can mitigate the impact of missing traces. We considered the prestack data as a 5D multidimensional array or otherwise referred to as a 5D tensor. Using synthetic data sets, we first found that prestack data can be well approximated by a low-rank tensor under a recently proposed framework for tensor singular value decomposition (tSVD). Under this low-rank assumption, we proposed a complexity-penalized algorithm for the recovery of missing traces and data denoising. In this algorithm, the complexity regularization was controlled by tuning a single regularization parameter using a statistical test. We tested the performance of the proposed algorithm on synthetic and real data to show that missing data can be reliably recovered under heavy downsampling. In addition, we demonstrated that compressibility, i.e., approximation of the data by a low-rank tensor, of seismic data under tSVD depended on the velocity model complexity and shot and receiver spacing. We further found that compressibility correlated with the recovery of missing data because high compressibility implied good recovery and vice versa.National Science Foundation (U.S.). Graduate Research Fellowship (Grant DGE-0806676)National Science Foundation (U.S.). Division of Computing and Communication Foundations (Grant NSF-1319653

Sry delivery to the adrenal medulla increases blood pressure and adrenal medullary tyrosine hydroxylase of normotensive WKY rats

BACKGROUND: Our laboratory has shown that a locus on the SHR Y chromosome increases blood pressure (BP) in the SHR rat and in WKY rats that had the SHR Y chromosome locus crossed into their genome (SHR/y rat). A potential candidate for this Y chromosome hypertension locus is Sry, a gene that encodes a transcription factor that is responsible for testes development and the Sry protein may affect other target genes. METHODS: The following study examined if exogenous Sry would elevate adrenal Th, adrenal catecholamines, plasma catecholamines and blood pressure. We delivered 10 μg of either the expression construct, Sry1/pcDNA 3.1, or control vector into the adrenal medulla of WKY rats by electroporation. Blood pressure was measured by the tail cuff technique and Th and catecholamines by HPLC with electrochemical detection. RESULTS: In the animals receiving Sry there were significant increases after 3 weeks in resting plasma NE (57%) and adrenal Th content (49%) compared to vector controls. BP was 30 mmHg higher in Sry injected animals (160 mmHg, p < .05) compared to vector controls (130 mmHg) after 2–3 weeks. Histological analysis showed that the electroporation procedure did not produce morphological damage. CONCLUSION: These results provide continued support that Sry is a candidate gene for hypertension. Also, these results are consistent with a role for Sry in increasing BP by directly or indirectly activating sympathetic nervous system activity

When does the action start and finish? Making the case for an ethnographic action research in educational research

This paper explores how ethnographic and action research methodologies can be justifiably combined to create a new methodological approach in educational research. It draws on existing examples in both educational research and development studies that have discussed the use of ethnography and action research in specific projects. Interpretations of ethnography and action research are developed that aim to minimise the epistemological differences between them. The paper also contextualises an ‘ethnographic action research’ approach with reference to an example of the author’s research into participation in three ‘reception’ (first year of schooling) classes in the United Kingdom. It is argued that research into the theme of participation in early years education, using participative methods, was particularly suitable for this new methodological approach

The glacial geomorphology of the western cordilleran ice sheet and Ahklun ice cap, Southern Alaska

During the late Wisconsinan, Southern Alaska was covered by two large ice masses; the western arm of the Cordilleran Ice Sheet and the Ahklun Mountains Ice Cap. Compared to the other ice sheets that existed during this period (e.g. the British-Irish, Laurentide and Fennoscandian ice sheets), little is known about the geomorphology they left behind. This limits our understanding of their flow pattern and retreat. Here we present systematic mapping of the glacial geomorphology of the two ice masses which existed in Southern Alaska. Due to spatially variable data availability, mapping was conducted using digital elevation models and satellite images of varying resolutions. Offshore, we map the glacial geomorphology using available bathymetric data. For the first time, we document >5000 subglacial lineations, recording ice flow direction. The distribution of moraines is presented, as well as features related to glacial meltwater drainage patterns (eskers and meltwater channels). Prominent troughs were also mapped on Alaska's continental shelf. This map provides the data required for a glacial inversion of these palaeo-ice masses

Gamma radiation survey of the LDEF spacecraft

The retrieval of the Long Duration Exposure Facility spacecraft in January 1990 after nearly six years in orbit offered a unique opportunity to study the long term buildup of induced radioactivity in the variety of materials on board. We conducted the first complete gamma-ray survey of a large spacecraft on LDEF shortly after its return to earth. A surprising observation was the Be-7 activity which was seen primarily on the leading edge of the satellite, implying that it was picked up by LDEF in orbit. This is the first known evidence for accretion of a radioactive isotope onto an orbiting spacecraft. Other isotopes observed during the survey, the strongest being Na-22, are all attributed to activation of spacecraft components. Be-7 is a spallation product of cosmic rays on nitrogen and oxygen in the upper atmosphere. However, the observed density is much greater than expected due to cosmic-ray production in situ. This implies transport of Be-7 from much lower altitudes up to the LDEF orbit

Variables associated with odds of finishing and finish time in a 161-km ultramarathon

We sought to determine the degree to which age, sex, calendar year, previous event experience and ambient race day temperature were associated with finishing a 100-mile (161-km) trail running race and with finish time in that race. We computed separate generalized linear mixed-effects regression models for (1) odds of finishing and (2) finish times of finishers. Every starter from 1986 to 2007 was used in computing the models for odds of finishing (8,282 starts by 3,956 individuals) and every finisher in the same period was included in the models for finish time (5,276 finishes). Factors associated with improved odds of finishing included being a first-time starter and advancing calendar year. Factors associated with reduced odds of finishing included advancing age above 38 years and warmer weather. Beyond 38 years of age, women had worse odds of finishing than men. Warmer weather had a similar effect on finish rates for men and women. Finish times were slower with advancing age, slower for women than men, and less affected by warm weather for women than for men. Calendar year was not associated with finish time after adjustment for other variables