Shear bands and cracking of metallic glass plates in bending

The thickness dependence of yielding and fracture of metallic glass plates subjected to bending is considered in terms of the shear band processes responsible for these properties. We argue that the shear band spacing (and length) scales with the thickness of the plate because of strain relaxation in the vicinity of the shear band at the surface. This is consistent with recent measurements of shear band spacing versus sample size. We also argue that the shear displacements in the shear band scale with the shear band length and plate thickness, thus causing cracks to be initiated in thicker plates at smaller bending strains. This leads to fracture bending strains that decrease markedly with increasing plate thickness, consistent with recent experiments. These results suggest that amorphous metals in the form of foams might have superior ductility and toughness

Randomised field trial to evaluate serological response after foot-and-mouth disease vaccination in Turkey

AbstractDespite years of biannual mass vaccination of cattle, foot-and-mouth disease (FMD) remains uncontrolled in Anatolian Turkey. To evaluate protection after mass vaccination we measured post-vaccination antibodies in a cohort of cattle (serotypes O, A and Asia-1). To obtain results reflecting typical field protection, participants were randomly sampled from across Central and Western Turkey after routine vaccination. Giving two-doses one month apart is recommended when cattle are first vaccinated against FMD. However, due to cost and logistics, this is not routinely performed in Turkey, and elsewhere. Nested within the cohort, we conducted a randomised trial comparing post-vaccination antibodies after a single-dose versus a two-dose primary vaccination course.Four to five months after vaccination, only a third of single-vaccinated cattle had antibody levels above a threshold associated with protection. A third never reached this threshold, even at peak response one month after vaccination. It was not until animals had received three vaccine doses in their lifetime, vaccinating every six months, that most (64% to 86% depending on serotype) maintained antibody levels above this threshold. By this time cattle would be >20 months old with almost half the population below this age. Consequently, many vaccinated animals will be unprotected for much of the year. Compared to a single-dose, a primary vaccination course of two-doses greatly improved the level and duration of immunity. We concluded that the FMD vaccination programme in Anatolian Turkey did not produce the high levels of immunity required. Higher potency vaccines are now used throughout Turkey, with a two-dose primary course in certain areas.Monitoring post-vaccination serology is an important component of evaluation for FMD vaccination programmes. However, consideration must be given to which antigens are present in the test, the vaccine and the field virus. Differences between these antigens affect the relationship between antibody titre and protection

The missing piece of the South Atlantic jigsaw: when continental break-up ignores crustal heterogeneity

Crustal heterogeneity is considered to play a critical role in the position of continental break-up, yet this can only be demonstrated when a fully constrained pre-break-up configuration of both conjugate margins is achievable. Limitations in our understanding of the pre-break-up crustal structure in the offshore region of many margins preclude this. In the southern South Atlantic, which is an archetypal conjugate margin, this can be achieved because of the high confidence in plate reconstruction. Prior to addressing the role of crustal heterogeneity, two questions have to be addressed: first, what is the location of the regionally extensive Gondwanan Orogeny that remains enigmatic in the Orange Basin, offshore South Africa; and, second, although it has been established that the Argentinian Colorado rift basin has an east–west trend perpendicular to the Orange Basin and Atlantic spreading, where is the western continuation of this east–west trend? We present here a revised structural model for the southern South Atlantic by identifying the South African fold belt offshore. The fold belt trend changes from north–south to east–west offshore and correlates directly with the restored Colorado Basin. The Colorado–Orange rifts form a tripartite system with the Namibian Gariep Belt, which we call the Garies Triple Junction. All three rift branches were active during the break-up of Gondwana, but during the Atlantic rift phase the Colorado Basin failed while the other two branches continued to rift, defining the present day location of the South Atlantic. In addressing these two outstanding questions, this study challenges the premise that crustal heterogeneity controls the position of continental break-up because seafloor spreading demonstrably cross-cuts the pre-existing crustal heterogeneity. Furthermore, we highlight the importance of differentiating between early rift evolution and subsequent rifting that occurs immediately prior to seafloor spreading

Interaction of crustal heterogeneity and lithospheric processes in determining passive margin architecture on the southern Namibian margin

The influence of pre-rift crustal heterogeneity and structure on the evolution of a continental rift and its subsequent passive margin is explored. The absence of thick Aptian salts in the Namibian South Atlantic allows imaging of sufficient resolution to distinguish different pre-rift basement seismic facies. Aspects of the pre-rift basement geometry were characterized and compared with the geometries of the Cretaceous rift basin structure and with subsequent post-rift margin architectural elements. Half-graben depocentres migrated westwards within the continental synrift phase at the same time as basin-bounding faults became established as hard-linked arrays with lengths of c. 100 km. The rift–drift transition phase, marked by seaward-dipping reflectors, gave way to the early post-rift progradation of clastic sediments off the Namibian coast. In the Late Cretaceous, these shelf clastic sediments were much thicker in the south, reflecting the dominance of the newly formed Orange River catchment as the main entry point for sediments on the South African–Namibian margin. Tertiary clastic sediments largely bypassed the pre-existing shelf area, revealing a marked basinwards shift in sedimentation. The thickness of post-rift megasequences does not vary simply according to the location of synrift half-graben and thinned continental crust. Instead, the Namibian margin exemplifies a margin influenced by a complex interplay of crustal thinning, pre-rift basement heterogeneity, volcanic bodies and transient dynamic uplift events on the evolution of lithospheric strain and depositional architecture

Standards of lithium monitoring in mental health trusts in the UK

Background Lithium is a commonly prescribed drug with a narrow therapeutic index, and recognised adverse effects on the kidneys and thyroid. Clinical guidelines for the management of bipolar affective disorder published by The National Institute for Health and Clinical Excellence (NICE) recommend checks of renal and thyroid function before lithium is prescribed. They further recommend that all patients who are prescribed lithium should have their renal and thyroid function checked every six months, and their serum lithium checked every three months. Adherence to these recommendations has not been subject to national UK audit. Methods The Prescribing Observatory for Mental Health (POMH-UK) invited all National Health Service Mental Health Trusts in the UK to participate in a benchmarking audit of lithium monitoring against recommended standards. Data were collected retrospectively from clinical records and submitted electronically. Results 436 clinical teams from 38 Trusts submitted data for 3,373 patients. In patients recently starting lithium, there was a documented baseline measure of renal or thyroid function in 84% and 82% respectively. For patients prescribed lithium for a year or more, the NICE standards for monitoring lithium serum levels, and renal and thyroid function were met in 30%, 55% and 50% of cases respectively. Conclusions The quality of lithium monitoring in patients who are in contact with mental health services falls short of recognised standards and targets. Findings from this audit, along with reports of harm received by the National Patient Safety Agency, prompted a Patient Safety Alert mandating primary care, mental health and acute Trusts, and laboratory staff to work together to ensure systems are in place to support recommended lithium monitoring by December 2010

How to increase earthquake and home fire preparedness: the fix-it intervention

Published, evaluated community intervention studies concerning natural hazard preparedness are rare. Most lack a rigorous methodology, thereby hampering the development of evidence-based interventions. This paper describes the rationale and methodology of a cross-cultural, longitudinal intervention study on earthquake and home fire preparedness, termed fix-it. The aim is to evaluate whether and how the intervention brings about behaviour change in the targeted communities in two coastal cities with high seismic risk: Seattle, USA and Izmir, Turkey. Participants are adult residents of these cities. The intervention group attends a 6-h workshop, which focuses on securing items in the household. The control group does not attend the workshop. All participants complete baseline and post-intervention, as well as 3- and 12-month follow-up assessments. The primary outcome measure is an observational measure of nine preparedness items for earthquake and fire in participants’ homes. This is evaluated alongside participants’ self-reports concerning their preparedness levels. Secondary outcomes are changes in levels of self-efficacy, perceived outcome, trust, corruption, empowerment, anxiety and social cohesion. Results from the first of the studies, conducted in Seattle in September 2015, indicate that while the fix-it intervention is effective, in the longer term, multi-hazard preparedness is increased by the mere act of going into people’s homes to observe their preparedness levels along with assessing self-reported preparedness and sociopsychological orientation towards natural hazards. This protocol and study aim to augment the empirical literature on natural hazard preparedness, informing national and international policy on delivery of evidence-based community interventions to promote multi-hazard preparedness in households

Community responses to communication campaigns for influenza A (H1N1): a focus group study

<p>Abstract</p> <p>Background</p> <p>This research was a part of a contestable rapid response initiative launched by the Health Research Council of New Zealand and the Ministry of Health in response to the 2009 influenza A pandemic. The aim was to provide health authorities in New Zealand with evidence-based practical information to guide the development and delivery of effective health messages for H1N1 and other health campaigns. This study contributed to the initiative by providing qualitative data about community responses to key health messages in the 2009 and 2010 H1N1 campaigns, the impact of messages on behavioural change and the differential impact on vulnerable groups in New Zealand.</p> <p>Methods</p> <p>Qualitative data were collected on community responses to key health messages in the 2009 and 2010 Ministry of Health H1N1 campaigns, the impact of messages on behaviour and the differential impact on vulnerable groups. Eight focus groups were held in the winter of 2010 with 80 participants from groups identified by the Ministry of Health as vulnerable to the H1N1 virus, such as people with chronic health conditions, pregnant women, children, Pacific Peoples and Māori. Because this study was part of a rapid response initiative, focus groups were selected as the most efficient means of data collection in the time available. For Māori, focus group discussion (hui) is a culturally appropriate methodology.</p> <p>Results</p> <p>Thematic analysis of data identified four major themes: personal and community risk, building community strategies, responsibility and information sources. People wanted messages about specific actions that they could take to protect themselves and their families and to mitigate any consequences. They wanted transparent and factual communication where both good and bad news is conveyed by people who they could trust.</p> <p>Conclusions</p> <p>The responses from all groups endorsed the need for community based risk management including information dissemination. Engaging with communities will be essential to facilitate preparedness and build community resilience to future pandemic events. This research provides an illustration of the complexities of how people understand and respond to health messages related to the H1N1 pandemic. The importance of the differences identified in the analysis is not the differences per se but highlight problems with a "one size fits all" pandemic warning strategy.</p

Hipsters on Our High Streets: Consuming the Gentrification Frontier

Gentrification involves the displacement of working class populations, a phenomena most obviously manifest in the transformation of residential landscapes. But this is also palpable in the changes visible on many shopping streets, with locally-oriented stores serving poorer populations and ethnic minorities being replaced by 'hipster' stores such as 'real coffee' shops, vintage clothing stores and bars serving microbrews. These stores have been taken as a sign that the fortunes of struggling shopping streets are improving, with the new outlets often depicted as offering a better range of healthy, green and 'authentic' consumption choices than the shops they displace. However, this paper argues that we need to resist this form of retail change given it typically represents the first stage of a more thoroughgoing retail gentrification process, remaining suspicious of forms of hipster consumption which, while aesthetically 'improving' local shopping streets in deprived areas, actually encourage the colonisation of neighbourhoods by the more affluent