20 research outputs found
Rare events, escape rates and quasistationarity: some exact formulae
We present a common framework to study decay and exchanges rates in a wide
class of dynamical systems. Several applications, ranging form the metric
theory of continuons fractions and the Shannon capacity of contrained systems
to the decay rate of metastable states, are given
Hemophagocytic syndrome caused by primary herpes simplex virus 1 infection: report of a first case
Introduction: Hemophagocytic syndrome represents a severe hyperinflammatory condition by activated macrophages. Leading viral triggering agents are Epstein-Barr virus (EBV), cytomegalovirus (CMV), and adenovirus. Materials and methods: We present a patient with Wegener's granulomatosis on azathioprine and prednisone medication, who developed a life-threatening hemophagocytic syndrome. Positive plasma polymerase chain reaction (PCR) with negative serology revealed a primary, disseminated infection with herpes simplex virus-1 as the triggering pathogen. After treatment with acyclovir, high-dose steroids, immunoglobulins, and etoposide, the patient recovered. Conclusion: Early diagnosis of potentially underlying infections of hemophagocytic syndrome influences the therapeutic approach. It is important to consider a variety of infectious agents, particularly in immunosuppressed individuals. The reported case emphasizes the importance of screening for herpes simplex virus
Absolute Energy Level Positions in CdSe Nanostructures from Potential-Modulated Absorption Spectroscopy (EMAS)
YesSemiconductor nanostructures like CdSe quantum dots and colloidal nanoplatelets
exhibit remarkable optical properties, making them interesting for applications in optoelectronics
and photocatalysis. For both areas of application a detailed understanding of
the electronic structure is essential to achieve highly efficient devices. The electronic
structure can be probed using the fact that optical properties of semiconductor nanoparticles
are found to be extremely sensitive to the presence of excess charges that can for
instance be generated by means of an electrochemical charge transfer via an electrode.
Here we present the use of potential modulated absorption spectroscopy (EMAS) as
a versatile spectroelectrochemical method to obtain absolute band edge positions of
CdSe nanostructures versus a well-defined reference electrode under ambient conditions.
In this the spectral properties of the nanoparticles are monitored dependent on an
applied electrochemical potential. We developed a bleaching model that yields the lowest
electronic state in the conduction band of the nanostructures. A change in the band
edge positions caused by quantum confinement is shown both for CdSe quantum dots as
well as for colloidal nanoplatelets. In the case of CdSe quantum dots these findings are
in good agreement with tight binding calculations. The method presented is not limited
to CdSe nanostructures but can be used as a universal tool. Hence, this technique allows
the determination of absolute band edge positions of a large variety of materials used in
various applications
Infectious diseases in allogeneic haematopoietic stem cell transplantation: prevention and prophylaxis strategy guidelines 2016
Infektionskontrolle im OP: Präventions- und Isolierungsmaßnahmen bei multiresistenten Erregern
Inhibitory Effects of Novel Nucleoside and Nucleotide Analogues on Epstein—Barr Virus Replication
Hemophagocytic syndrome caused by primary herpes simplex virus 1 infection: report of a first case
INTRODUCTION: Hemophagocytic syndrome represents a severe hyperinflammatory condition by activated macrophages. Leading viral triggering agents are Epstein-Barr virus (EBV), cytomegalovirus (CMV), and adenovirus. MATERIALS AND METHODS: We present a patient with Wegener's granulomatosis on azathioprine and prednisone medication, who developed a life-threatening hemophagocytic syndrome. Positive plasma polymerase chain reaction (PCR) with negative serology revealed a primary, disseminated infection with herpes simplex virus-1 as the triggering pathogen. After treatment with acyclovir, high-dose steroids, immunoglobulins, and etoposide, the patient recovered. CONCLUSION: Early diagnosis of potentially underlying infections of hemophagocytic syndrome influences the therapeutic approach. It is important to consider a variety of infectious agents, particularly in immunosuppressed individuals. The reported case emphasizes the importance of screening for herpes simplex virus 1