Economics-Based Optimization of Unstable Flows

As an example for the optimization of unstable flows, we present an economics-based method for deciding the optimal rates at which vehicles are allowed to enter a highway. It exploits the naturally occuring fluctuations of traffic flow and is flexible enough to adapt in real time to the transient flow characteristics of road traffic. Simulations based on realistic parameter values show that this strategy is feasible for naturally occurring traffic, and that even far from optimality, injection policies can improve traffic flow. Moreover, the same method can be applied to the optimization of flows of gases and granular media.Comment: Revised version of ``Optimizing Traffic Flow'' (cond-mat/9809397). For related work see http://www.parc.xerox.com/dynamics/ and http://www.theo2.physik.uni-stuttgart.de/helbing.htm

Use of the Kawa Model to Facilitate Interprofessional Collaboration: A Pilot Study

Purpose: The Kawa (river in Japanese) model uses the metaphor of a river to view one’s life from a metaphysical perspective, with consideration given to the interaction between social and physical environments, life circumstances, assets, and liabilities. Preliminary research suggests that the Kawa model may be an effective tool for interprofessional collaboration, but studies employing the model with diverse groups of healthcare professionals have not been undertaken. The purpose of this pilot study was to determine if the Kawa model could serve as an effective collaboration tool for a diverse healthcare team within a skilled nursing facility. Method: A pilot study using survey methodology was conducted with an interprofessional team (N=10) involving rehabilitation, nursing, administration, social work, and activities personnel. Education on the Kawa model and its components was provided to the team, followed by their participation in an interactive activity involving application of the model to a case study. An author-generated survey was administered before and after the study to elicit views about the Kawa model’s potential use as a team collaboration tool. Results: All 10/10 participants agreed or strongly agreed the Kawa model provides a common language for interprofessional collaboration, and 9/10 felt it would be an effective tool to increase collaboration in their facility. Conclusions: Healthcare professionals from a variety of fields must collaborate effectively for quality client care. Using a tool, such as the Kawa model, may provide a common ground for interprofessional discussions when making decisions about a client’s care. Recommendations include replication of this study with larger, more diverse healthcare teams, incorporation of an actual client and his or her family in the team, and comparison of other collaborative practices with those employing the Kawa model

Intermittent exploration on a scale-free network

We study an intermittent random walk on a random network of scale-free degree distribution. The walk is a combination of simple random walks of duration $t_w$ and random long-range jumps. While the time the walker needs to cover all the nodes increases with $t_w$, the corresponding time for the edges displays a non monotonic behavior with a minimum for some nontrivial value of $t_w$. This is a heterogeneity-induced effect that is not observed in homogeneous small-world networks. The optimal $t_w$ increases with the degree of assortativity in the network. Depending on the nature of degree correlations and the elapsed time the walker finds an over/under-estimate of the degree distribution exponent.Comment: 12 pages, 3 figures, 1 table, published versio

Pearl millet downy mildew in Gujarat

A field survey was undertaken to monitor downy mildew (Sclerospora graminicola) incidence on 21 pearl millet (Pennisetum glaucum) hybrids in 88 fields in Gujarat in the rainy season of 2001. Downy mildew incidence was recorded in 2 m2 subplots as the ratio of diseased to total plants at the soft-dough to hard-dough growth stage. Some seed lots were treated with metalaxyl. Disease incidence varied with location and was very variable (1-86% in Kheda). Of the 15 hybrid cultivars from private seed companies, seven were free from downy mildew (Amul, MRB 2210, Nandi 3, PAC 931, Proagro 7501, 9330 and Vikram 51) and eight had mean incidences from 9 to 55%. Of the six public-sector hybrids, only GHB 235 was free from disease, the remaining five had mean incidences from 2-68%. The cropping sequence pearl millet - cowpea - maize - pearl millet reduced downy mildew incidence more than other combinations (10% downy mildew incidence)

Loss of a 20S Proteasome Activator in Saccharomyces cerevisiae Downregulates Genes Important for Genomic Integrity, Increases DNA Damage, and Selectively Sensitizes Cells to Agents With Diverse Mechanisms of Action

Cytoprotective functions of a 20S proteasome activator were investigated. Saccharomyces cerevisiae Blm10 and human 20S proteasome activator 200 (PA200) are homologs. Comparative genome-wide analyses of untreated diploid cells lacking Blm10 and growing at steady state at defined growth rates revealed downregulation of numerous genes required for accurate chromosome structure, assembly and repair, and upregulation of a specific subset of genes encoding protein-folding chaperones. Blm10 loss or truncation of the Ubp3/Blm3 deubiquitinating enzyme caused massive chromosomal damage and cell death in homozygous diploids after phleomycin treatments, indicating that Blm10 and Ubp3/Blm3 function to stabilize the genome and protect against cell death. Diploids lacking Blm10 also were sensitized to doxorubicin, hydroxyurea, 5-fluorouracil, rapamycin, hydrogen peroxide, methyl methanesulfonate, and calcofluor. Fluorescently tagged Blm10 localized in nuclei, with enhanced fluorescence after DNA replication. After DNA damage that caused a classic G2/M arrest, fluorescence remained diffuse, with evidence of nuclear fragmentation in some cells. Protective functions of Blm10 did not require the carboxyl-terminal region that makes close contact with 20S proteasomes, indicating that protection does not require this contact or the truncated Blm10 can interact with the proteasome apart from this region. Without its carboxyl-terminus, Blm10(−339aa) localized to nuclei in untreated, nonproliferating (G0) cells, but not during G1 S, G2, and M. The results indicate Blm10 functions in protective mechanisms that include the machinery that assures proper assembly of chromosomes. These essential guardian functions have implications for ubiquitin-independent targeting in anticancer therapy. Targeting Blm10/PA200 together with one or more of the upregulated chaperones or a conventional treatment could be efficacious

Boron Nitride Monolayer: A Strain-Tunable Nanosensor

The influence of triaxial in-plane strain on the electronic properties of a hexagonal boron-nitride sheet is investigated using density functional theory. Different from graphene, the triaxial strain localizes the molecular orbitals of the boron-nitride flake in its center depending on the direction of the applied strain. The proposed technique for localizing the molecular orbitals that are close to the Fermi level in the center of boron nitride flakes can be used to actualize engineered nanosensors, for instance, to selectively detect gas molecules. We show that the central part of the strained flake adsorbs polar molecules more strongly as compared with an unstrained sheet.Comment: 20 pages, 9 figure

Are textbook lungs really normal? A cadaveric study on the anatomical and clinical importance of variations in the major lung fissures, and the incomplete right horizontal fissure.

INTRODUCTION: The lungs have three main fissures: the right oblique fissure (ROF), right horizontal fissure (RHF), and left oblique fissure (LOF). These can be complete, incomplete or absent; quantifying the degree of completeness of these fissures is novel. Standard textbooks often refer to the fissures as complete, but awareness of variation is essential in thoracic surgery. MATERIALS AND METHODS: Fissures in 81 pairs of cadaveric lungs were classified. Oblique fissures were measured from lung hila posteriorly to the lung hila anteriorly; and the RHF measured from the ROF to the anteromedial lung edge. The degree of completeness of fissures was expressed as a percentage of the total projected length were they to be complete. The frequency and location of accessory fissures was noted. RESULTS: LOF were complete in 66/81 (81.5%), incomplete in 13/81 (16.0%) and absent in 2/81 (2.47%); ROF were complete in 52/81 (64.2%), incomplete in 29/81 (35.8%) and never absent; RHF were more variable, complete in 18/81 (22.2%), incomplete in 54/81 (66.7%) and absent in 9/81 (11.1%). LOF and ROF were on average 97.1% and 91.6% complete, respectively, being deficient posteriorly at the lung hila. The RHF on average 69.4% complete, being deficient anteromedially. There were accessory fissures in 10 left and 19 right lungs. CONCLUSIONS: This study provides a projection of the anatomy thoracic surgeons may encounter at operation, in particular the variable RHF. This knowledge is essential for optimal outcomes in both benign and oncological procedures influenced by the fissures

Annealing study and thermal investigation on bismuth sulfide thin films prepared by chemical bath deposition in basic medium

This is a post-peer-review, pre-copyedit version of an article published in Applied Physics A 124.2 (2018): 166. The final authenticated version is available online at: http://doi.org/10.1007/s00339-018-1584-7Bismuth sulfide thin films were prepared by chemical bath deposition using thiourea as sulfide ion source in basic medium. First, the effects of both the deposition parameters on films growth as well as the annealing effect under argon and sulfur atmosphere on as-deposited thin films were studied. The parameters were found to be influential using the Doehlert matrix experimental design methodology. Ranges for a maximum surface mass of films (3 mg cm-2) were determined. A well crystallized major phase of bismuth sulfide with stoichiometric composition was achieved at 190°C for 3 hours. The prepared thin films were characterized using Grazing Incidence X-ray diffraction (GIXRD), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray analysis (EDX). Second, the band gap energy value was found to be 1.5 eV. Finally, the thermal properties have been studied for the first time by means of the electropyroelectric (EPE) technique. Indeed, the thermal conductivity varied in the range of 1.20 - 0.60 W m-1 K-1 while the thermal diffusivity values increased in terms of the annealing effect ranging from 1.8 to 3.5 10-7 m2s-1This work was financially supported by the Tunisian Ministry of Higher Education and Scientific Research and by the WINCOST (ENE2016-80788-C5-2-R) project funded by the Spanish Ministry of Economy and Competitivenes

Host resistance stability to downy mildew in pearl millet and pathogenic variability in Sclerospora graminicola

Downy mildew, caused by Sclerospora graminicola, is a major pathogen of pearl millet (Pennisetum glaucum) in Asia and Africa. So development of resistant cultivars has been a major goal of national and international breeding programs. Stability of resistance in pearl millet lines developed at ICRISAT was studied through a collaborative International Pearl Millet Downy Mildew Virulence Nursery (IPMDMVN). The reactions to downy mildew of 11 pearl millet lines at 17 locations in India, Burkina Faso, Mali, Niger, and Nigeria from 1995 to 1999 were recorded. Disease incidence varied significantly among lines, locations, and years. The tested pearl millet lines exhibited significant differential resistance. Resistance in lines IP 18292, IP 18293, 700651 and P 310-17 was most stable regardless of the location or season. Analysis of the variation in resistance also suggested that the resistance in IP 18292 and IP 18293 was variable and depended on the locations and years, while the resistance in 700651 and P 310-17 was highly stable across locations and over years. The latter two lines could prove to be the most valuable sources of downy mildew resistance. The results also revealed significant differences in S. graminicola populations at different locations, with the highest disease at Bagauda (Nigeria) and Durgapura (India) and lowest from Coimbatore and Aurangabad (India). Based on the reaction of the 11 pearl millet lines, the 17 S. graminicola populations were grouped into six putative pathotypes (undefined populations closer to races)