176 research outputs found
Measurement of 1.7 to 74 MeV polarised gamma rays with the HARPO TPC
Current {\gamma}-ray telescopes based on photon conversions to
electron-positron pairs, such as Fermi, use tungsten converters. They suffer of
limited angular resolution at low energies, and their sensitivity drops below 1
GeV. The low multiple scattering in a gaseous detector gives access to higher
angular resolution in the MeV-GeV range, and to the linear polarisation of the
photons through the azimuthal angle of the electron-positron pair.
HARPO is an R&D program to characterise the operation of a TPC (Time
Projection Chamber) as a high angular-resolution and sensitivity telescope and
polarimeter for {\gamma} rays from cosmic sources. It represents a first step
towards a future space instrument. A 30 cm cubic TPC demonstrator was built,
and filled with 2 bar argon-based gas. It was put in a polarised {\gamma}-ray
beam at the NewSUBARU accelerator in Japan in November 2014. Data were taken at
different photon energies from 1.7 MeV to 74 MeV, and with different
polarisation configurations. The electronics setup is described, with an
emphasis on the trigger system. The event reconstruction algorithm is quickly
described, and preliminary measurements of the polarisation of 11 MeVphotons
are shown.Comment: Proceedings VCI201
Experimental evaluation of interfaces using atomic-resolution high angle annular dark field (HAADF) imaging
Aberration-corrected highangleannulardarkfield (HAADF) imaging in scanning transmission electron microscopy (STEM) can now be performed at atomic-resolution. This is an important tool for the characterisation of the latest semiconductor devices that require individual layers to be grown to an accuracy of a few atomic layers. However, the actual quantification of interfacial sharpness at the atomic-scale can be a complicated matter. For instance, it is not clear how the use of the total, atomic column or background HAADF signals can affect the measured sharpness or individual layer widths. Moreover, a reliable and consistent method of measurement is necessary. To highlight these issues, two types of AlAs/GaAs interfaces were studied in-depth by atomic-resolutionHAADFimaging. A method of analysis was developed in order to map the various HAADF signals across an image and to reliably determine interfacial sharpness. The results demonstrated that the level of perceived interfacial sharpness can vary significantly with specimen thickness and the choice of HAADF signal. Individual layer widths were also shown to have some dependence on the choice of HAADF signal. Hence, it is crucial to have an awareness of which part of the HAADF signal is chosen for analysis along with possible specimen thickness effects for future HAADF studies performed at the scale of a few atomic layers
Large-scale prospective genome-wide association study of oxaliplatin in stage II/III colon cancer and neuropathy
[Background] The severity of oxaliplatin (L-OHP)-induced peripheral sensory neuropathy (PSN) exhibits substantial interpatient variability, and some patients suffer from long-term, persisting PSN. To identify single-nucleotide polymorphisms (SNPs) predicting L-OHP-induced PSN using a genome-wide association study (GWAS) approach. [Patients and methods] A large prospective GWAS including 1379 patients with stage II/III colon cancer who received L-OHP-based adjuvant chemotherapy (mFOLFOX6/CAPOX) under the phase II (JOIN/JFMC41) or the phase III (ACHIVE/JFMC47) trial. Firstly, GWAS comparison of worst grade PSN (grade 0/1 versus 2/3) was carried out. Next, to minimize the impact of ambiguity in PSN grading, extreme PSN phenotypes were selected and analyzed by GWAS. SNPs that could predict time to recovery from PSN were also evaluated. In addition, SNPs associated with L-OHP-induced allergic reactions (AR) and time to disease recurrence were explored. [Results] No SNPs exceeded the genome-wide significance (P < 5.0 × 10−8) in either GWAS comparison of worst grade PSN, extreme PSN phenotypes, or time to recovery from PSN. An association study focusing on AR or time to disease recurrence also failed to reveal any significant SNPs. [Conclusion] Our results highlight the challenges of utilizing SNPs for predicting susceptibility to L-OHP-induced PSN in daily clinical practice
One-dimensional Topological Edge States of Bismuth Bilayers
The hallmark of a time-reversal symmetry protected topologically insulating
state of matter in two-dimensions (2D) is the existence of chiral edge modes
propagating along the perimeter of the system. To date, evidence for such
electronic modes has come from experiments on semiconducting heterostructures
in the topological phase which showed approximately quantized values of the
overall conductance as well as edge-dominated current flow. However, there have
not been any spectroscopic measurements to demonstrate the one-dimensional (1D)
nature of the edge modes. Among the first systems predicted to be a 2D
topological insulator are bilayers of bismuth (Bi) and there have been recent
experimental indications of possible topological boundary states at their
edges. However, the experiments on such bilayers suffered from irregular
structure of their edges or the coupling of the edge states to substrate's bulk
states. Here we report scanning tunneling microscopy (STM) experiments which
show that a subset of the predicted Bi-bilayers' edge states are decoupled from
states of Bi substrate and provide direct spectroscopic evidence of their 1D
nature. Moreover, by visualizing the quantum interference of edge mode
quasi-particles in confined geometries, we demonstrate their remarkable
coherent propagation along the edge with scattering properties that are
consistent with strong suppression of backscattering as predicted for the
propagating topological edge states.Comment: 15 pages, 5 figures, and supplementary materia
The unprecedented optical outburst of the quasar 3C 454.3. The WEBT campaign of 2004-2005
The radio quasar 3C 454.3 underwent an exceptional optical outburst lasting
more than 1 year and culminating in spring 2005. The maximum brightness
detected was R = 12.0, which represents the most luminous quasar state thus far
observed (M_B ~ -31.4). In order to follow the emission behaviour of the source
in detail, a large multiwavelength campaign was organized by the Whole Earth
Blazar Telescope (WEBT). Continuous optical, near-IR and radio monitoring was
performed in several bands. ToO pointings by the Chandra and INTEGRAL
satellites provided additional information at high energies in May 2005. The
historical radio and optical light curves show different behaviours. Until
about 2001.0 only moderate variability was present in the optical regime, while
prominent and long-lasting radio outbursts were visible at the various radio
frequencies, with higher-frequency variations preceding the lower-frequency
ones. After that date, the optical activity increased and the radio flux is
less variable. This suggests that the optical and radio emissions come from two
separate and misaligned jet regions, with the inner optical one acquiring a
smaller viewing angle during the 2004-2005 outburst. Moreover, the colour-index
behaviour (generally redder-when-brighter) during the outburst suggests the
presence of a luminous accretion disc. A huge mm outburst followed the optical
one, peaking in June-July 2005. The high-frequency (37-43 GHz) radio flux
started to increase in early 2005 and reached a maximum at the end of our
observing period (end of September 2005). VLBA observations at 43 GHz during
the summer confirm theComment: 7 pages, 4 figures, to be published in A&
The WEBT Campaign on the Blazar 3C279 in 2006
The quasar 3C279 was the target of an extensive multiwavelength monitoring
campaign from January through April 2006, including an optical-IR-radio
monitoring campaign by the Whole Earth Blazar Telescope (WEBT) collaboration.
In this paper we focus on the results of the WEBT campaign. The source
exhibited substantial variability of optical flux and spectral shape, with a
characteristic time scale of a few days. The variability patterns throughout
the optical BVRI bands were very closely correlated with each other. In
intriguing contrast to other (in particular, BL Lac type) blazars, we find a
lag of shorter- behind longer-wavelength variability throughout the RVB ranges,
with a time delay increasing with increasing frequency. Spectral hardening
during flares appears delayed with respect to a rising optical flux. This, in
combination with the very steep IR-optical continuum spectral index of ~ 1.5 -
2.0, may indicate a highly oblique magnetic field configuration near the base
of the jet. An alternative explanation through a slow (time scale of several
days) acceleration mechanism would require an unusually low magnetic field of <
0.2 G, about an order of magnitude lower than inferred from previous analyses
of simultaneous SEDs of 3C279 and other FSRQs with similar properties.Comment: Accepted for publication in Ap
The radio delay of the exceptional 3C 454.3 outburst. Follow-up WEBT observations in 2005-2006
In spring 2005 the blazar 3C 454.3 was observed in an unprecedented bright
state from the near-IR to the hard X-ray frequencies. A mm outburst peaked in
June-July 2005, and it was followed by a flux increase at high radio
frequencies. In this paper we report on multifrequency monitoring by the WEBT
aimed at following the further evolution of the outburst in detail. In
particular, we investigate the expected correlation and time delays between the
optical and radio emissions in order to derive information on the variability
mechanisms and jet structure. A comparison among the light curves at different
frequencies is performed by means of visual inspection and discrete correlation
function, and the results are interpreted with a simple model taking into
account Doppler factor variations of geometric origin. The high-frequency radio
light curves show a huge outburst starting during the dimming phase of the
optical one and lasting more than 1 year. The first phase is characterized by a
slow flux increase, while in early 2006 a major flare is observed. The
lower-frequency radio light curves show a progressively delayed and fainter
event, which disappears below 8 GHz. We suggest that the radio major peak is
not physically connected with the spring 2005 optical one, but it is actually
correlated with a minor optical flare observed in October-November 2005. This
interpretation involves both an intrinsic and a geometric mechanism. The former
is represented by disturbances travelling down the emitting jet, the latter
being due to the curved-jet motion, with the consequent differential changes of
viewing angles of the different emitting regions.Comment: 5 pages, 3 figures, to be published in A&A (Letters
Observation of weak neutral current neutrino production of
Observation of \jpsi production by neutrinos in the calorimeter of the CHORUS detector exposed to the CERN SPS wide-band \numu beam is reported. A spectrum-averaged cross-section = (6.3 3.0) is obtained for 20 GeV 200 GeV. The data are compared with the theoretical model based on the QCD Z-gluon fusion mechanism
- …