762 research outputs found
Antiferromagnetism at T > 500 K in the Layered Hexagonal Ruthenate SrRu2O6
We report an experimental and computational study of magnetic and electronic
properties of the layered Ru(V) oxide SrRu2O6 (hexagonal, P-3 1m), which shows
antiferromagnetic order with a N\'eel temperature of 563(2) K, among the
highest for 4d oxides. Magnetic order occurs both within edge-shared octahedral
sheets and between layers and is accompanied by anisotropic thermal expansivity
that implies strong magnetoelastic coupling of Ru(V) centers. Electrical
transport measurements using focused ion beam induced deposited contacts on a
micron-scale crystallite as a function of temperature show p-type
semiconductivity. The calculated electronic structure using hybrid density
functional theory successfully accounts for the experimentally observed
magnetic and electronic structure and Monte Carlo simulations reveals how
strong intralayer as well as weaker interlayer interactions are a defining
feature of the high temperature magnetic order in the material.Comment: Physical Review B 2015 accepted for publicatio
Expression of TNF-related apoptosis-inducing ligand (TRAIL) in keratinocytes mediates apoptotic cell death in allogenic T cells
The objective of the present study was to evaluate the aptitude of TRAIL gene expression for inducing apoptosis in co-cultivated T-cells. This should allow preparing a strategy for the development of a durable, allogenic skin substitute based on the induction of an immune-privileged transplant. In order to counteract the significant potential of rejection in transplanted allogenic keratinocytes, we created a murine keratinocyte cell line which expressed TRAIL through stable gene transfer. The exogenic protein was localized on the cellular surface and was not found in soluble condition as sTRAIL. Contact to TRAIL expressing cells in co-culture induced cell death in sensitive Jurkat-cells, which was further intensified by lymphocyte activation. This cytotoxic effect is due to the induction of apoptosis. We therefore assume that the de-novo expression of TRAIL in keratinocytes can trigger apoptosis in activated lymphocytes and thus prevent the rejection of keratinocytes in allogenic, immune-privileged transplants
Assessing the cost of global biodiversity and conservation knowledge
Knowledge products comprise assessments of authoritative information supported by
standards, governance, quality control, data, tools, and capacity building mechanisms.
Considerable resources are dedicated to developing and maintaining knowledge
products for biodiversity conservation, and they are widely used to inform policy and
advise decision makers and practitioners. However, the financial cost of delivering this
information is largely undocumented. We evaluated the costs and funding sources for
developing and maintaining four global biodiversity and conservation knowledge
products: The IUCN Red List of Threatened Species, the IUCN Red List of
Ecosystems, Protected Planet, and the World Database of Key Biodiversity Areas.
These are secondary data sets, built on primary data collected by extensive networks
of expert contributors worldwide. We estimate that US116-204
million), plus 293 person-years of volunteer time (range: 278-308 person-years) valued
at US12-16 million), were invested in these four knowledge
products between 1979 and 2013. More than half of this financing was provided
through philanthropy, and nearly three-quarters was spent on personnel costs. The
estimated annual cost of maintaining data and platforms for three of these knowledge
products (excluding the IUCN Red List of Ecosystems for which annual costs were not
possible to estimate for 2013 ) is US6.2-6.7 million).
We estimated that an additional US12 million. These costs
are much lower than those to maintain many other, similarly important, global
knowledge products. Ensuring that biodiversity and conservation knowledge products
are sufficiently up to date, comprehensive and accurate is fundamental to inform
decision-making for biodiversity conservation and sustainable development. Thus, the
development and implementation of plans for sustainable long-term financing for them
is critical
Data-driven modeling of electron recoil nucleation in PICO C3F8 bubble chambers
[EN] The primary advantage of moderately superheated bubble chamber detectors is their simultaneous sensitivity to nuclear recoils from weakly interacting massive particle (WIMP) dark matter and insensitivity to electron recoil backgrounds. A comprehensive analysis of PICO gamma calibration data demonstrates for the first time that electron recoils in C3F8 scale in accordance with a new nucleation mechanism, rather than one driven by a hot spike as previously supposed. Using this semiempirical model, bubble chamber nucleation thresholds may be tuned to be sensitive to lower energy nuclear recoils while maintaining excellent electron recoil rejection. The PICO-40L detector will exploit this model to achieve thermodynamic thresholds as low as 2.8 keV while being dominated by single-scatter events from coherent elastic neutrino-nucleus scattering of solar neutrinos. In one year of operation, PICO-401, can improve existing leading limits from PICO on spin-dependent WIMP-proton coupling by nearly an order of magnitude for WIMP masses greater than 3 GeV c(-2) and will have the ability to surpass all existing non-xenon bounds on spin-independent WIMP-nucleon coupling for WIMP masses from 3 to 40 GeV c(-2).The PICO Collaboration wishes to thank SNOLAB and
its staff for support through underground space, logistical
and technical services. SNOLAB operations are supported
by the Canada Foundation for Innovation and the Province
of Ontario Ministry of Research and Innovation, with
underground access provided by Vale at the Creighton
mine site. We wish to acknowledge the support of the
Natural Sciences and Engineering Research Council of
Canada (NSERC) and the Canada Foundation for
Innovation (CFI) for funding. We acknowledge the support
from National Science Foundation (NSF) (Grants
No. 0919526, No. 1506337, No. 1242637, No. 1205987,
and No. 1806722). We acknowledge that this work is
supported by the U.S. Department of Energy (DOE) Office
of Science, Office of High Energy Physics (under Award
No. DE-SC-0012161), by DGAPA-UNAM (PAPIIT
No. IA100118) and Consejo Nacional de Ciencia y
TecnologÃa (CONACyT, M¿exico, Grants No. 252167 and
No. A1-S-8960), by the Department of Atomic Energy
(DAE), Government of India, under the Centre for AstroParticle Physics II project (CAPP-II) at the Saha
Institute of Nuclear Physics (SINP), European Regional
Development Fund¿Project ¿Engineering Applications of
Microworld Physics¿ (Project No. CZ.02.1.01/0.0/0.0/
16_019/0000766), and the Spanish Ministerio de Ciencia,
Innovación y Universidades (Red Consolider MultiDark,
Grant No. FPA2017-90566-REDC). This work is partially
supported by the Kavli Institute for Cosmological Physics at
the University of Chicago through NSF Grant No. 1125897,
and an endowment from the Kavli Foundation and its
founder Fred Kavli. We also wish to acknowledge the
support from Fermi National Accelerator Laboratory under
Contract No. DE-AC02-07CH11359, and Pacific Northwest
National Laboratory, which is operated by Battelle for the
U.S. Department of Energy under Contract No. DE-AC05-
76RL01830. We also thank Compute Canada [75] and the
Center for Advanced Computing, ACENET, Calcul Qu¿ebec,
Compute Ontario, and WestGrid for computational support.Amole, C.; Ardid RamÃrez, M.; Arnquist, I.; Asner, DM.; Baxter, D.; Behnke, E.; Bressler, M.... (2019). Data-driven modeling of electron recoil nucleation in PICO C3F8 bubble chambers. Physical Review D: covering particles, fields, gravitation, and cosmology. 100(8):1-18. https://doi.org/10.1103/PhysRevD.100.082006S1181008Amole, C., Ardid, M., Arnquist, I. J., Asner, D. M., Baxter, D., Behnke, E., … Chen, C. J. (2019). Dark matter search results from the complete exposure of the PICO-60
C3F8
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Journal of Instrumentation, 14(08), P08019-P08019. doi:10.1088/1748-0221/14/08/p08019Agostinelli, S., Allison, J., Amako, K., Apostolakis, J., Araujo, H., Arce, P., … Barrand, G. (2003). Geant4—a simulation toolkit. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 506(3), 250-303. doi:10.1016/s0168-9002(03)01368-8Pozzi, S. A., Padovani, E., & Marseguerra, M. (2003). MCNP-PoliMi: a Monte-Carlo code for correlation measurements. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 513(3), 550-558. doi:10.1016/j.nima.2003.06.012Archambault, S., Aubin, F., Auger, M., Beleshi, M., Behnke, E., … Behnke, J. (2011). New insights into particle detection with superheated liquids. New Journal of Physics, 13(4), 043006. doi:10.1088/1367-2630/13/4/043006Glaser, D. A. (1954). Progress report on the development of bubble chambers. 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The effective field theory of dark matter direct detection. Journal of Cosmology and Astroparticle Physics, 2013(02), 004-004. doi:10.1088/1475-7516/2013/02/004Anand, N., Fitzpatrick, A. L., & Haxton, W. C. (2014). Weakly interacting massive particle-nucleus elastic scattering response. Physical Review C, 89(6). doi:10.1103/physrevc.89.065501Gresham, M. I., & Zurek, K. M. (2014). Effect of nuclear response functions in dark matter direct detection. Physical Review D, 89(12). doi:10.1103/physrevd.89.123521Gluscevic, V., Gresham, M. I., McDermott, S. D., Peter, A. H. G., & Zurek, K. M. (2015). Identifying the theory of dark matter with direct detection. Journal of Cosmology and Astroparticle Physics, 2015(12), 057-057. doi:10.1088/1475-7516/2015/12/057Aprile, E., Aalbers, J., Agostini, F., Alfonsi, M., Althueser, L., Amaro, F. D., … Baudis, L. (2019). Constraining the Spin-Dependent WIMP-Nucleon Cross Sections with XENON1T. 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Modelling of the effect of ELMs on fuel retention at the bulk W divertor of JET
Effect of ELMs on fuel retention at the bulk W target of JET ITER-Like Wall was studied with multi-scale calculations. Plasma input parameters were taken from ELMy H-mode plasma experiment. The energetic intra-ELM fuel particles get implanted and create near-surface defects up to depths of few tens of nm, which act as the main fuel trapping sites during ELMs. Clustering of implantation-induced vacancies were found to take place. The incoming flux of inter-ELM plasma particles increases the different filling levels of trapped fuel in defects. The temperature increase of the W target during the pulse increases the fuel detrapping rate. The inter-ELM fuel particle flux refills the partially emptied trapping sites and fills new sites. This leads to a competing effect on the retention and release rates of the implanted particles. At high temperatures the main retention appeared in larger vacancy clusters due to increased clustering rate
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