8,698 research outputs found
DSIF station schedules
System manages Deep Space Instrumentation Facilities /DSIF/ equipment construction and modification planning. Versatile program applies to such tasks as employee time and task schedules, pay schedules, operations schedules, and plant and equipment procurement, construction, modification or service
Cost-effectiveness of initial stress cardiovascular MR, stress SPECT or stress echocardiography as a gate-keeper test, compared with upfront invasive coronary angiography in the investigation and management of patients with stable chest pain: Mid-term outcomes from the CECaT randomised controlled trial
Objectives: To compare outcomes and cost-effectiveness of various initial imaging strategies in the management of stable chest pain in a long-term prospective randomised trial. Setting: Regional cardiothoracic referral centre in the east of England. Participants: 898 patients (69% man) entered the study with 869 alive at 2 years of follow-up. Patients were included if they presented for assessment of stable chest pain with a positive exercise test and no prior history of ischaemic heart disease. Exclusion criteria were recent infarction, unstable symptoms or any contraindication to stress MRI. Primary outcome measures: The primary outcomes of this follow-up study were survival up to a minimum of 2 years post-treatment, quality-adjusted survival and cost-utility of each strategy. Results: 898 patients were randomised. Compared with angiography, mortality was marginally higher in the groups randomised to cardiac MR (HR 2.6, 95% CI 1.1 to 6.2), but similar in the single photon emission CT-methoxyisobutylisonitrile (SPECT-MIBI; HR 1.0, 95% CI 0.4 to 2.9) and ECHO groups (HR 1.6, 95% CI 0.6 to 4.0). Although SPECT-MIBI was marginally superior to other non-invasive tests there were no other significant differences between the groups in mortality, quality-adjusted survival or costs. Conclusions: Non-invasive cardiac imaging can be used safely as the initial diagnostic test to diagnose coronary artery disease without adverse effects on patient outcomes or increased costs, relative to angiography. These results should be interpreted in the context of recent advances in imaging technology. Trial registration: ISRCTN 47108462, UKCRN 3696
Singularity theory study of overdetermination in models for L-H transitions
Two dynamical models that have been proposed to describe transitions between
low and high confinement states (L-H transitions) in confined plasmas are
analysed using singularity theory and stability theory. It is shown that the
stationary-state bifurcation sets have qualitative properties identical to
standard normal forms for the pitchfork and transcritical bifurcations. The
analysis yields the codimension of the highest-order singularities, from which
we find that the unperturbed systems are overdetermined bifurcation problems
and derive appropriate universal unfoldings. Questions of mutual equivalence
and the character of the state transitions are addressed.Comment: Latex (Revtex) source + 13 small postscript figures. Revised versio
Catastrophic regime shifts in model ecological communities are true phase transitions
Ecosystems often undergo abrupt regime shifts in response to gradual external
changes. These shifts are theoretically understood as a regime switch between
alternative stable states of the ecosystem dynamical response to smooth changes
in external conditions. Usual models introduce nonlinearities in the
macroscopic dynamics of the ecosystem that lead to different stable attractors
among which the shift takes place. Here we propose an alternative explanation
of catastrophic regime shifts based on a recent model that pictures ecological
communities as systems in continuous fluctuation, according to certain
transition probabilities, between different micro-states in the phase space of
viable communities. We introduce a spontaneous extinction rate that accounts
for gradual changes in external conditions, and upon variations on this control
parameter the system undergoes a regime shift with similar features to those
previously reported. Under our microscopic viewpoint we recover the main
results obtained in previous theoretical and empirical work (anomalous
variance, hysteresis cycles, trophic cascades). The model predicts a gradual
loss of species in trophic levels from bottom to top near the transition. But
more importantly, the spectral analysis of the transition probability matrix
allows us to rigorously establish that we are observing the fingerprints, in a
finite size system, of a true phase transition driven by background
extinctions.Comment: 19 pages, 11 figures, revised versio
Green Infrastructure in Coastal Landscapes: Ecological Design, Hydrological Function, and Sustainable Land Use Goals
2012 S.C. Water Resources Conference - Exploring Opportunities for Collaborative Water Research, Policy and Managemen
Catastrophic Phase Transitions and Early Warnings in a Spatial Ecological Model
Gradual changes in exploitation, nutrient loading, etc. produce shifts
between alternative stable states (ASS) in ecosystems which, quite often, are
not smooth but abrupt or catastrophic. Early warnings of such catastrophic
regime shifts are fundamental for designing management protocols for
ecosystems. Here we study the spatial version of a popular ecological model,
involving a logistically growing single species subject to exploitation, which
is known to exhibit ASS. Spatial heterogeneity is introduced by a carrying
capacity parameter varying from cell to cell in a regular lattice. Transport of
biomass among cells is included in the form of diffusion. We investigate
whether different quantities from statistical mechanics -like the variance, the
two-point correlation function and the patchiness- may serve as early warnings
of catastrophic phase transitions between the ASS. In particular, we find that
the patch-size distribution follows a power law when the system is close to the
catastrophic transition. We also provide links between spatial and temporal
indicators and analyze how the interplay between diffusion and spatial
heterogeneity may affect the earliness of each of the observables. We find that
possible remedial procedures, which can be followed after these early signals,
are more effective as the diffusion becomes lower. Finally, we comment on
similarities and differences between these catastrophic shifts and paradigmatic
thermodynamic phase transitions like the liquid-vapour change of state for a
fluid like water
The Clumping Transition in Niche Competition: a Robust Critical Phenomenon
We show analytically and numerically that the appearance of lumps and gaps in
the distribution of n competing species along a niche axis is a robust
phenomenon whenever the finiteness of the niche space is taken into account. In
this case depending if the niche width of the species is above or
below a threshold , which for large n coincides with 2/n, there are
two different regimes. For the lumpy pattern emerges
directly from the dominant eigenvector of the competition matrix because its
corresponding eigenvalue becomes negative. For the lumpy
pattern disappears. Furthermore, this clumping transition exhibits critical
slowing down as is approached from above. We also find that the number
of lumps of species vs. displays a stair-step structure. The positions
of these steps are distributed according to a power-law. It is thus
straightforward to predict the number of groups that can be packed along a
niche axis and it coincides with field measurements for a wide range of the
model parameters.Comment: 16 pages, 7 figures;
http://iopscience.iop.org/1742-5468/2010/05/P0500
Drosophila CENP-A Mutations Cause a BubR1- Dependent Early Mitotic Delay without Normal Localization of Kinetochore Components
The centromere/kinetochore complex plays an essential role in cell and organismal viability by ensuring chromosome movements during mitosis and meiosis. The kinetochore also mediates the spindle attachment checkpoint (SAC), which delays anaphase initiation until all chromosomes have achieved bipolar attachment of kinetochores to the mitotic spindle. CENP-A proteins are centromere-specific chromatin components that provide both a structural and a functional foundation for kinetochore formation. Here we show that cells in Drosophila embryos homozygous for null mutations in CENP-A (CID) display an early mitotic delay. This mitotic delay is not suppressed by inactivation of the DNA damage checkpoint and is unlikely to be the result of DNA damage. Surprisingly, mutation of the SAC component BUBR1 partially suppresses this mitotic delay. Furthermore, cid mutants retain an intact SAC response to spindle disruption despite the inability of many kinetochore proteins, including SAC components, to target to kinetochores. We propose that SAC components are able to monitor spindle assembly and inhibit cell cycle progression in the absence of sustained kinetochore localization
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