450 research outputs found
Plasmid-mediated AmpC β-lactamases in Enterobacteriaceae lacking inducible chromosomal ampC genes: prevalence at a Swiss university hospital and occurrence of the different molecular types in Switzerland
Temporal behavior of the inverse spin Hall voltage in a magnetic insulator-nonmagnetic metal structure
It is demonstrated that upon pulsed microwave excitation, the temporal
behavior of a spin-wave induced inverse spin Hall voltage in a magnetic
insulator-nonmagnetic metal structure is distinctly different from the temporal
evolution of the directly excited spin-wave mode from which it originates. The
difference in temporal behavior is attributed to the excitation of long-lived
secondary spin-wave modes localized at the insulator-metal interface
Subcutaneous Haemangiosarcoma in a Cockatiel ( Nymphicus hollandicus )
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74932/1/j.1439-0442.2006.00825.x.pd
Power Versus Affiliation in Political Ideology
Posited motivational differences between liberals and conservatives have historically been controversial. This motivational interface has recently been bridged, but the vast majority of studies have used self-reports of values or motivation. Instead, the present four studies investigated whether two classic social motive themes—power and affiliation—vary by political ideology in objective linguistic analysis terms. Study 1 found that posts to liberal chat rooms scored higher in standardized affiliation than power, whereas the reverse was true of posts to conservative chat rooms. Study 2 replicated this pattern in the context of materials posted to liberal versus conservative political news websites. Studies 3 and 4, finally, replicated a similar interactive (ideology by motive type) pattern in State of the State and State of the Union addresses. Differences in political ideology, these results suggest, are marked by, and likely reflective of, mind-sets favoring affiliation (liberal) or power (conservative). </jats:p
Facial expressions depicting compassionate and critical emotions: the development and validation of a new emotional face stimulus set
Attachment with altruistic others requires the ability to appropriately process affiliative and kind facial cues. Yet there is no stimulus set available to investigate such processes. Here, we developed a stimulus set depicting compassionate and critical facial expressions, and validated its effectiveness using well-established visual-probe methodology. In Study 1, 62 participants rated photographs of actors displaying compassionate/kind and critical faces on strength of emotion type. This produced a new stimulus set based on N = 31 actors, whose facial expressions were reliably distinguished as compassionate, critical and neutral. In Study 2, 70 participants completed a visual-probe task measuring attentional orientation to critical and compassionate/kind faces. This revealed that participants lower in self-criticism demonstrated enhanced attention to compassionate/kind faces whereas those higher in self-criticism showed no bias. To sum, the new stimulus set produced interpretable findings using visual-probe methodology and is the first to include higher order, complex positive affect displays
Outcome of Reverse Switching From CT-P13 to Originator Infliximab in Patients With Inflammatory Bowel Disease
BACKGROUND: Patients suffering from inflammatory bowel diseases (IBD) and treated with originator infliximab are increasingly being switched to biosimilars. Some patients, however, are "reverse switched" to treatment with the originator. Here we assess the prevalence of reverse switching, including its indication and outcomes. METHODS: In this retrospective multicenter cohort study, data on patients with IBD from 9 hospitals in the Netherlands were collected. All adult patients with IBD were included if they previously had been switched from originator infliximab to the biosimilar CT-P13 and had a follow-up time of at least 52 weeks after the initial switch. The reasons for reverse switching were categorized into worsening gastrointestinal symptoms, adverse effects, or loss of response to CT-P13. Drug persistence was analyzed through survival analyses. RESULTS: A total of 758 patients with IBD were identified. Reverse switching was observed in 75 patients (9.9%). Patients with reverse switching were predominantly female (70.7%). Gastrointestinal symptoms (25.5%) and dermatological symptoms (21.8%) were the most commonly reported reasons for reverse switching. In 9 patients (12.0%), loss of response to CT-P13 was the reason for reverse switching. Improvement of reported symptoms was seen in 73.3% of patients after reverse switching and 7 out of 9 patients (77.8%) with loss of response regained response. Infliximab persistence was equal between patients who were reverse-switched and those who were maintained on CT-P13. CONCLUSIONS: Reverse switching occurred in 9.9% of patients, predominantly for biosimilar-attributed adverse effects. Switching back to originator infliximab seems effective in patients who experience adverse effects, worsening gastrointestinal symptoms, or loss of response after switching from originator infliximab to CT-P13
Development of a prototype superconducting radio-frequency cavity for conduction-cooled accelerators
The higher efficiency of superconducting radio-frequency (SRF) cavities
compared to normal-conducting ones enables the development of high-energy
continuous-wave linear accelerators (linacs). Recent progress in the
development of high-quality NbSn film coatings along with the availability
of cryocoolers with high cooling capacity at 4 K makes it feasible to operate
SRF cavities cooled by thermal conduction at relevant accelerating gradients
for use in accelerators. A possible use of conduction-cooled SRF linacs is for
environmental applications, requiring electron beams with energy of
MeV and 1 MW of power. We have designed a 915 MHz SRF linac for such an
application and developed a prototype single-cell cavity to prove the proposed
design by operating it with cryocoolers at the accelerating gradient required
for 1 MeV energy gain. The cavity has a m thick NbSn film on
the inner surface, deposited on a mm thick bulk Nb substrate and a bulk
mm thick Cu outer shell with three Cu attachment tabs. The cavity was
tested up to a peak surface magnetic field of 53 mT in liquid He at 4.3 K. A
horizontal test cryostat was designed and built to test the cavity cooled with
three Gifford-McMahon cryocoolers. The rf tests of the conduction-cooled
cavity, performed at General Atomics, achieved a peak surface magnetic field of
50 mT and stable operation was possible with up to 18.5 W of rf heat load. The
peak frequency shift due to microphonics was 23 Hz. These results represent the
highest peak surface magnetic field achieved in a conduction-cooled SRF cavity
to date and meet the requirements for a 1 MeV energy gain
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De novo assembly of the cattle reference genome with single-molecule sequencing.
BackgroundMajor advances in selection progress for cattle have been made following the introduction of genomic tools over the past 10-12 years. These tools depend upon the Bos taurus reference genome (UMD3.1.1), which was created using now-outdated technologies and is hindered by a variety of deficiencies and inaccuracies.ResultsWe present the new reference genome for cattle, ARS-UCD1.2, based on the same animal as the original to facilitate transfer and interpretation of results obtained from the earlier version, but applying a combination of modern technologies in a de novo assembly to increase continuity, accuracy, and completeness. The assembly includes 2.7 Gb and is >250× more continuous than the original assembly, with contig N50 >25 Mb and L50 of 32. We also greatly expanded supporting RNA-based data for annotation that identifies 30,396 total genes (21,039 protein coding). The new reference assembly is accessible in annotated form for public use.ConclusionsWe demonstrate that improved continuity of assembled sequence warrants the adoption of ARS-UCD1.2 as the new cattle reference genome and that increased assembly accuracy will benefit future research on this species
Collective phase description of globally coupled excitable elements
We develop a theory of collective phase description for globally coupled
noisy excitable elements exhibiting macroscopic oscillations. Collective phase
equations describing macroscopic rhythms of the system are derived from
Langevin-type equations of globally coupled active rotators via a nonlinear
Fokker-Planck equation. The theory is an extension of the conventional phase
reduction method for ordinary limit cycles to limit-cycle solutions in
infinite-dimensional dynamical systems, such as the time-periodic solutions to
nonlinear Fokker-Planck equations representing macroscopic rhythms. We
demonstrate that the type of the collective phase sensitivity function near the
onset of collective oscillations crucially depends on the type of the
bifurcation, namely, it is type-I for the saddle-node bifurcation and type-II
for the Hopf bifurcation.Comment: 18 pages, 6 figure
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