Neighbourhood property value and type 2 diabetes mellitus in the Maastricht study: A multilevel study

Objective Low individual socioeconomic status (SES) is known to be associated with a higher risk of type 2 diabetes mellitus (T2DM), but the extent to which the local context in which people live may influence T2DM rates remains unclear. This study examines whether living in a low property value neighbourhood is associated with higher rates of T2DM independently of individual SES. Research design and methods Using cross-sectional data from the Maastricht Study (2010\u20132013) and geographical data from Statistics Netherlands, multilevel logistic regression was used to assess the association between neighbourhood property value and T2DM. Individual SES was based on education, occupation and income. Of the 2,056 participants (aged 40\u201375 years), 494 (24%) were diagnosed with T2DM. Results Individual SES was strongly associated with T2DM, but a significant proportion of the variance in T2DM was found at the neighbourhood level (VPC = 9.2%; 95% CI = 5.0%\u201316%). Participants living in the poorest neighbourhoods had a 2.38 times higher odds ratio of T2DM compared to those living in the richest areas (95% CI = 1.58\u20133.58), independently of individual SES. Conclusions Neighbourhood property value showed a significant association with T2DM, suggesting the usefulness of area-based programmes aimed at improving neighbourhood characteristics in order to tackle inequalities in T2DM

Numerical simulation of barge impact on a continuous girder bridge and bridge damage detection

Vessel collisions on bridge piers have been frequently reported. As many bridges are vital in transportation networks and serve as lifelines, bridge damage might leads to catastrophic consequences to life and economy. Therefore it is of great importance to protect bridge structures, especially bridge piers, against vessel impacts. Many researches have been conducted to predict vessel impact loads on bridge piers, and to design bridge piers or additional protective structures to resist such impact loads. Studies on assessing the bridge conditions after a vessel impact are, however, very limited. Current practice basically uses visual inspections, which not only requires very experienced engineers to perform the inspection in order to obtain creditable assessment, but also is often very difficult to inspect the underwater pier conditions. Therefore it is necessary to develop methods to give efficient, quantitative and reliable assessment of bridge conditions under ambient conditions after a vessel impact. This study explores the feasibility of using vibration measurements to quickly detect bridge conditions after a vessel impact.The study consists of three parts. First, a detailed numerical model of an example bridge structure is developed to calculate the vibrations under ambient hydrodynamic force. Then the model is used to simulate vessel impact on bridge pier and predict the pier damage. The vibration response analysis of the damaged bridge model is performed again in the third step to simulate vibration responses of the damaged bridge under ambient conditions. Using the vibration data obtained before and after vessel impact, the bridge vibration parameters such as vibration frequencies and mode shapes are extracted by using the frequency domain decomposition method. The bridge condition will then be identified through the changes in bridge vibration parameters and compared with the damage observed in the impact simulation. It is found that this method is capable of estimating bridge damage condition after barge impact accident

EFSA Panel on Dietetic Products, Nutrition, and Allergies (NDA); Scientific Opinion on Dietary reference values for water

This Opinion of the EFSA Panel on Dietetic Products, Nutrition, and Allergies (NDA) deals with the setting of dietary reference values for water for specific age groups. Adequate Intakes (AI) have been defined derived from a combination of observed intakes in population groups with desirable osmolarity values of urine and desirable water volumes per energy unit consumed. The reference values for total water intake include water from drinking water, beverages of all kind, and from food moisture and only apply to conditions of moderate environmental temperature and moderate physical activity levels (PAL 1.6). AIs for infants in the first half of the first year of life are estimated to be 100-190 mL/kg per day. For infants 6-12 months of age a total water intake of 800-1000 mL/day is considered adequate. For the second year of life an adequate total water intake of 1100-1200 mL/day is defined by interpolation, as intake data are not available. AIs of water for children are estimated to be 1300 mL/day for boys and girls 2-3 years of age; 1600 mL/day for boys and girls 4-8 years of age; 2100 mL/day for boys 9-13 years of age; 1900 mL/day for girls 9-13 years of age. Adolescents of 14 years and older are considered as adults with respect to adequate water intake. Available data for adults permit the definition of AIs as 2.0 L/day (P 95 3.1 L) for females and 2.5 L/day (P95 4.0 L) for males. The same AIs as for adults are defined for the elderly. For pregnant women the same water intake as in non-pregnant women plus an increase in proportion to the increase in energy intake (300 mL/day) is proposed. For lactating women adequate water intakes of about 700 mL/day above the AIs of non-lactating women of the same age are derive

Cholesterol and Lipoprotein Dynamics in a Hibernating Mammal

Hibernating mammals cease feeding during the winter and rely primarily on stored lipids to fuel alternating periods of torpor and arousal. How hibernators manage large fluxes of lipids and sterols over the annual hibernation cycle is poorly understood. The aim of this study was to investigate lipid and cholesterol transport and storage in ground squirrels studied in spring, summer, and several hibernation states. Cholesterol levels in total plasma, HDL and LDL particles were elevated in hibernators compared with spring or summer squirrels. Hibernation increased plasma apolipoprotein A-I expression and HDL particle size. Expression of cholesterol 7 alpha-hydroxylase was 13-fold lower in hibernators than in active season squirrels. Plasma triglycerides were reduced by fasting in spring but not summer squirrels. In hibernators plasma β-hydroxybutyrate was elevated during torpor whereas triglycerides were low relative to normothermic states. We conclude that the switch to a lipid-based metabolism during winter, coupled with reduced capacity to excrete cholesterol creates a closed system in which efficient use of lipoproteins is essential for survival