Predicting Initial Mental Health/Substance Abuse Treatment Attendance in HIV/AIDS Patients: An Exploration of Risk Factors

This study attempted to predict mental health/substance abuse treatment initial appointment attendance, utilizing specific social, provider, institutional, medical, and psychological risk factors through the use of a logistic regression model. The initial frequency analysis revealed that only 155 individuals were ever scheduled to attend an appointment of the original data set (N=298). The majority of individuals could not be scheduled due to unavailability, disinterest, latency and other reasons. A new data set was created from individuals who were scheduled and variables were collapsed across categories to include: length of wait time to appointment, CD4 count, prescribed medications, reason for referral, and past history/ current substance abuse in the model. This study did not find any of the identified risk factors or the proposed model (c2 (6, N=155) =5.66, p= .46) to be significantly predictive of treatment attendance. However, the clinical implications of pre-treatment dropout (or never attending) in this study support the importance of a behavioral health model of treatment. The findings of this study suggest pre-treatment dropout could be decreased with integrated treatment in the primary care setting, especially for HIV/AIDS patients

Susceptibility of SARS-CoV2 infection in children

Coronavirus disease 2019 in children presents with distinct phenotype in comparison to adults. Overall, the pediatric infection with a generally milder clinical course of the acute infection compared to adults still faces several unknown aspects. Specifically, the presence of a wide range of inflammatory manifestations, including multisystem inflammatory syndrome in children (MIS-C), myocarditis, and long COVID in the period after infection suggests a particular susceptibility of some children upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Albeit peculiar complications such as long covid are less frequent in children compared to adults, research on the relationship between inflammatory syndromes and SARS-CoV-2 is rapidly evolving. Conclusions: new studies and findings continue to emerge, providing further insights into the underlying mechanisms and potential therapeutic strategies. In the present work, we revised current knowledge of the main factors accounting for such variability upon SARS-CoV-2 infection over the pediatric age group.What is Known:& BULL; COVID19 in children overall showed a milder course compared to adults during the acute phase of the infection.& BULL; Children showed to be susceptible to a wide range of post infectious complications including multisystem inflammatory syndrome in children (MIS-C), myocarditis, neuroinflammation, and long COVID.What is New:& BULL; Mechanisms underlying susceptibility to a severe course of the infection were recently shown to pertain to the host.& BULL; A specific combination of HLA was recently shown to be associated to higher susceptibility to MIS-C in children

Identification of the plastic zone using digital image correlation

In this paper Digital Image Correlation (DIC) is used to study the evolution of the plastic zone close to a crack tip. A modified CT-specimen was used in order to fulfill the plane stress condition. The strain field around the crack tip was measured using two cameras and stereo DIC, so that out-of-plane movements are taken into account. Then, the Virtual Fields Method was used to identify the plastic zone, looking at the parts of the specimen which deviates from the linear elastic behavior. With such approach, it was possible to individuate the onset of plasticity close to the crack tip and follow its evolution. A comparison with FEM results is also provided

Ischemic cardiovascular disease in workers occupationally exposed to urban air pollution – A systematic review

Introduction. Cardiovascular disease is the first cause of morbidity and mortality worldwide. Among several known risk factors, researchers also focus their attention on the chronic exposure to air pollution. There is much evidence that exposure to air pollution, especially to ultrafine particles, can damage the endothelium and can favour cardiovascular diseases in the general population. Occupational exposition could be an additive risk factor for the cardiovascular system. This article presents a scientific review of the linkage between occupational exposure to air pollution and ischemic heart disease. Materials and method. A scientific review was undertaken, followed by PRISMA Statements. Observational studies were selected from several scientific databases, likesuch as Pubmed, Google Scholar, Nioshtic-2 and Reserchgate, searching for selected key words: police workers, professional drivers, mail carriers, filling station attendants, road cleaners, garage workers, motor vehicles and engine maintenance. All the key words were combined with “Boolean Operators” with the following words: cardiovascular (or cardiac) disease, cardiovascular function, cardiovascular system, ischemic heart disease, coronary disease, myocardial infarction. During the systematic research, the focus was on retrospective and prospective studies from January 1990 – December 2014. Results. Both the retrospective and prospective studies showed an increased risk of ischemic heart disease in occupationally occupied people exposed to air pollution. Only one study presented a ly minor risk. Conclusions. The findings of this systematic review suggest a possible linkage between occupational exposure to urban air pollution, especially to motor exhaust and particulate, and ischemic heart disease

Screening for Latent Tuberculosis Infection among Students of Healthcare Professions and Postgraduates of the Faculty of Medicine of the University of Palermo

Introduction and objective: Italy is a country with a low incidence of tuberculosis and in the last fifty years the annual number of TB cases decreased from 12,247 to 4,418, showing a reduction of approximately 64% in the number of cases and 71% in incidence. Despite of this encouraging trend, in the last years the epidemiology of tuberculosis changed and today it is a re-emerging infectious. The aim of this study is to measure the prevalence of positivity to tuberculosis infection (latent TB) in students, without any obvious manifestation of disease, attending degree courses of the health care professions and postgraduate medical courses of the School of Medicine of the University of Palermo, Italy. Materials and methods: A cross-sectional observational study in students of nursing, midwifery, dentistry degree courses and in resident physicians of postgraduate medical schools was carried out from January 2012 to July 2016. Mantoux test was performed and all positive cases were tested with Interferon-Gamma Release Assay (IGRA). Results: Of the 1,351 subjects evaluated, 25 (1.8%) resulted positive to Mantoux test; in 17 students (1.2%) the diagnosis was confirmed with IGRA. Positive cases were significantly more frequent among students attending Postgraduated Medical School Courses (p<0.001) and were older than negative cases (p<0.001). Conclusion: This study suggests that in our geographic area, latent TB shows a relatively low prevalence among students of medical schools. Despite of this evidence, and considering that several students have been found to be positive for TB, this infectious disease has to be considered a re-emerging biohazard that requires preventive strategies for the containment of the risk in exposed workers as well as in the general population

Recent Decisions

Comments on recent decisions by Thomas D. Logan, Bernard J. McGraw, Robert A. Stewart, Anthony V. Amodio, Frank A. Howard, Richard R. Murphy, Howard V. Burke, Robert D. Lightfoot, Robert A. Layden, James J. Haranzo, John M. Sullivan, and Robert C. Enburg

Use of the frozen elephant trunk technique for type B aortic dissection and aberrant right subclavian artery: an anatomic repair of the “arteria lusoria”

Retrograde extension into the aortic arch occurs in 16.5% of patients with type B aortic dissection (TBAD) (1). This cohort of patients may be eligible for a radical repair using the frozen elephant trunk (FET) technique. The combination of surgical replacement of the aortic arch and deployment of the stent graft allows complete exclusion of the false lumen in aortic dissections. In the case of aneurysm or residual dissection, patients undergoing FET are ready for subsequent endovascular or surgical treatment (2)

LncRNA NEAT1 in Paraspeckles: A Structural Scaffold for Cellular DNA Damage Response Systems?

Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNA) reported to be frequently deregulated in various types of cancers and neurodegenerative processes. NEAT1 is an indispensable structural component of paraspeckles (PSs), which are dynamic and membraneless nuclear bodies that affect different cellular functions, including stress response. Furthermore, increasing evidence supports the crucial role of NEAT1 and essential structural proteins of PSs (PSPs) in the regulation of the DNA damage repair (DDR) system. This review aims to provide an overview of the current knowledge on the involvement of NEAT1 and PSPs in DDR, which might strengthen the rationale underlying future NEAT1-based therapeutic options in tumor and neurodegenerative diseases