Simulation of the magnetosphere with a new three dimensional MHD code and adaptive mesh refinement: Preliminary results

We present the first results from a new unstructured mesh three dimensional finite element MHD code which uses dynamic solution-adaptive mesh refinement in a manner similar to our two dimensional finite element MHD code /31/. The problem being considered here is the interaction of the solar wind with the earth's magnetosphere, using a three-dimensional Cartesian approximation. Our results strongly indicate that such adaptive mesh techniques have the ability to resolve structures in the three dimensional MHD flow field that would otherwise be possible only with orders of magnitude greater cost and that are most likely beyond the capability of present supercomputers

A High-resolution Adaptive Moving Mesh Hydrodynamic Algorithm

An algorithm for simulating self-gravitating cosmological astrophysical fluids is presented. The advantages include a large dynamic range, parallelizability, high resolution per grid element and fast execution speed. The code is based on a finite volume flux conservative Total-Variation-Diminishing (TVD) scheme for the shock capturing hydro, and an iterative multigrid solver for the gravity. The grid is a time dependent field, whose motion is described by a generalized potential flow. Approximately constant mass per cell can be obtained, providing all the advantages of a Lagrangian scheme. The grid deformation combined with appropriate limiting and smoothing schemes guarantees a regular and well behaved grid geometry, where nearest neighbor relationships remain constant. The full hydrodynamic fluid equations are implemented in the curvilinear moving grid, allowing for arbitrary fluid flow relative to the grid geometry. This combination retains all the advantages of the grid based schemes including high speed per fluid element and a rapid gravity solver. The current implementation is described, and empirical simulation results are presented. Accurate execution speed calculations are given in terms of floating point operations per time step per grid cell. This code is freely available to the community.Comment: 53 pages including 14 figures, submitted to ApJ

Quantitative Validation of PEDFLOW for Description of Unidirectional Pedestrian Dynamics

The results of a systematic quantitative validation of PEDFLOW based on the experimental data from FZJ are presented. Uni- directional flow experiments, totaling 28 different combinations with varying entry, corridor and exit widths, were considered. The condition imposed on PEDFLOW was that all the cases should be run with the same input parameters. The exit times and fundamental diagrams for the measuring region were evaluated and compared. This validation process led to modifications and enhancements of the model underlying PEDFLOW. The preliminary conclusions indicate that the results agree well for densities smaller than 3 m-2 and a good agreement is observed even at high densities for the corridors with bcor = 2.4 m, and bcor = 3.0 m. For densities between 1 and 2 m-2 the specific flow and velocities are underpredicted by PEDFLOW. &nbsp

On the coupling of CFD and CSD methodologies for modeling blast-structure interactions

This paper describes applications of a coupled Computational Fluid Dynamics (CFD) and Computational Structural Dynamics (CSD) methodology to the simulation of blast waves generated by bare explosive charges in a test facility with rigid and deformable walls. The coupled algorithm combines FEFLO98 (CFD) and MARS3D (CSD) via an embedded approach, where the CSD objects float through the CFD domain. This combination enables an easier and more accurate prediction of structural deformation, cracking and failure under blast loading. Several experiments were conducted to characterize blast load and structural response as a function of charge size, weapon ignition point (nose or tail) and orientation (horizontal or vertical). The numerical simulations helped in understanding the experimental results, some of which were not intuitively understood. Good agreement between the experimental results and the numerical predictions were demonstrated for pressure data, blast loading and the corresponding structural response. Keywords: blast-structure interaction, coupled CFD and CSD, blast wave evolution, structural response to blast loading

Use of quercetin in animal feed : effects on the P-gp expression and pharmacokinetics of orally administrated enrofloxacin in chicken

Modulation of P-glycoprotein (P-gp, encoded by Mdr1) by xenobiotics plays central role in pharmacokinetics of various drugs. Quercetin has a potential to modulate P-gp in rodents, however, its effects on P-gp modulation in chicken are still unclear. Herein, study reports role of quercetin in modulation of P-gp expression and subsequent effects on the pharmacokinetics of enrofloxacin in broilers. Results show that P-gp expression was increased in a dose-dependent manner following exposure to quercetin in Caco-2 cells and tissues of chicken. Absorption rate constant and apparent permeability coefficient of rhodamine 123 were decreased, reflecting efflux function of P-gp in chicken intestine increased by quercetin. Quercetin altered pharmacokinetic of enrofloxacin by decreasing area under curve, peak concentration, and time to reach peak concentration and by increasing clearance rate. Molecular docking shows quercetin can form favorable interactions with binding pocket of chicken xenobiotic receptor (CXR). Results provide convincing evidence that quercetin induced P-gp expression in tissues by possible interaction with CXR, and consequently reducing bioavailability of orally administered enrofloxacin through restricting its intestinal absorption and liver/kidney clearance in broilers. The results can be further extended to guide reasonable use of quercetin to avoid drug-feed interaction occurred with co-administered enrofloxacin or other similar antimicrobials.Peer reviewedFinal Published versio

Ultrafast Coherent Generation of Hot Electrons Studied via Band-to-Acceptor Luminescence in GaAs

The distribution of hot electrons excited with femtosecond laser pulses is studied via spectrally resolved band-to-acceptor luminescence. Our data demonstrate for the first time that the coherent coupling between the laser pulse and the interband polarization strongly influences the initial carrier distribution. The energetic width of carrier generation is broadened due to rapid phase-breaking scattering events. Theoretical results from a Monte Carlo solution of the semiconductor Bloch equations including on the same kinetic level coherent and incoherent phenomena, are in excellent agreement with the experimental data

Excitonic and free-carrier polarizations of bulk GaAs studied by femtosecond coherent spectroscopy

The transient third-order polarization at the band gap of undoped and p-doped GaAs is investigated by spectrally and temporally resolved four-wave mixing. Excitonic and free-carrier contributions simultaneously excited within the bandwidth of the 100-fs pulses are clearly distinguished by their different spectral envelopes. The excitonic part dominates at carrier densities below 1016 cm-3 and shows a time evolution governed by exciton-free-carrier scattering and by many-body effects. At higher density, the free-carrier polarization has a strength similar to the exciton contribution and exhibits a spectrum resonant to the femtosecond pulses with a photon-echo-like temporal behavior. The data are analyzed by a numerical solution of the semiconductor Bloch equations including an ensemble Monte Carlo simulation of the scattering dynamics of the carriers. The theoretical model is in good agreement with the experimental results

Semileptonic Branching Fraction of Charged and Neutral B Mesons

An examination of leptons in ${\Upsilon (4S)}$ events tagged by reconstructed $B$ decays yields semileptonic branching fractions of $b_-=(10.1 \pm 1.8\pm 1.4)\%$ for charged and $b_0=(10.9 \pm 0.7\pm 1.1)\%$ for neutral $B$ mesons. This is the first measurement for charged $B$. Assuming equality of the charged and neutral semileptonic widths, the ratio $b_-/b_0=0.93 \pm 0.18 \pm 0.12$ is equivalent to the ratio of lifetimes. A postscript version is available through World-Wide-Web in http://w4.lns.cornell.edu/public/CLNS/1994Comment: 9 pages (in REVTEX format) Preprint CLNS94-1286, CLEO 94-1