4,300 research outputs found
Urban Prospects: A Search for Poetry in the American City Part 2
This thesis is about establishing an attitude about design which argues building organization, appearance and meaning. Architecture should be a reflection of culture rather than being an instagator of change
Present and Future Role of Immune Targets in Acute Myeloid Leukemia
It is now well known that the bone marrow (BM) cell niche contributes to leukemogenesis, but emerging data support the role of the complex crosstalk between AML cells and the BM microenvironment to induce a permissive immune setting that protects leukemic stem cells (LSCs) from therapy-induced death, thus favoring disease persistence and eventual relapse. The identification of potential immune targets on AML cells and the modulation of the BM environment could lead to enhanced anti-leukemic effects of drugs, immune system reactivation, and the restoration of AML surveillance. Potential targets and effectors of this immune-based therapy could be monoclonal antibodies directed against LSC antigens such as CD33, CD123, and CLL-1 (either as direct targets or via several bispecific T-cell engagers), immune checkpoint inhibitors acting on different co-inhibitory axes (alone or in combination with conventional AML drugs), and novel cellular therapies such as chimeric antigen receptor (CAR) T-cells designed against AML-specific antigens. Though dozens of clinical trials, mostly in phases I and II, are ongoing worldwide, results have still been negatively affected by difficulties in the identification of the optimal targets on LSCs
A PBW basis for Lusztig's form of untwisted affine quantum groups
Let be an untwisted affine Kac-Moody algebra over the field
, and let be the associated quantum enveloping
algebra; let be the Lusztig's integer form of , generated by -divided powers of Chevalley
generators over a suitable subring of . We prove a
Poincar\'e-Birkhoff-Witt like theorem for ,
yielding a basis over made of ordered products of -divided powers of
suitable quantum root vectors.Comment: 22 pages, AMS-TeX C, Version 2.1c. This is the author's final
version, corresponding to the printed journal versio
Mathematical Programming Algorithms for Spatial Cloaking
We consider a combinatorial optimization problem for spatial information
cloaking. The problem requires computing one or several disjoint arborescences on a
graph from a predetermined root or subset of candidate roots, so that the number of
vertices in the arborescences is minimized but a given threshold on the overall weight associated with the vertices in each arborescence is reached. For a single arborescence case, we solve the problem to optimality by designing a branch-and-cut exact algorithm. Then we
adapt this algorithm for the purpose of pricing out columns in an exact branch-and-price
algorithm for the multiarborescence version. We also propose a branch-and-price-based
heuristic algorithm, where branching and pricing, respectively, act as diversification and
intensification mechanisms. The heuristic consistently finds optimal or near optimal solutions within a computing time, which can be three to four orders of magnitude smaller
than that required for exact optimization. From an application point of view, our computational results are useful to calibrate the values of relevant parameters, determining the obfuscation level that is achieved
Alterations in rhinosinusal homeostasis in a sportive population: our experience with 106 athletes
The aim of the present work was to analyse the alterations of rhino-sinusal physiology in 106 professional athletes (swimmers, skiers, boxers and runners) using objective rhinological methods. Every athlete underwent an accurate anamnesis, a complete objective ORL evaluation, an active anterior rhinomanometry, an acoustic rhinometry and an evaluation of mucociliary transport time (MCTt). Skiers were also submitted to a nasal decongestion test (NDT). In swimmers, the mean MCTt was 27.4+/-4.97 min (normal value: 13+/-3 min; P<0.0001). The average MCTt for the skier group was 19.58+/-1.92 min ( P<0.0001); the mean value of total basal nasal resistance was 0.37+/-0.05 Pa/ml per s (normal value =0.25 Pa/ml per s; P<0.001). After NDT, total nasal resistance was 0.18+/-0.02 Pa/ml per s. In the group of boxers, the total mean nasal resistance was 0.64+/-0.05 Pa/ml per s ( P<0.001); the mean cross-sectional area at the nasal valve level was 0.57+/-0.04 cm(2) (normal value =0.55+/-0.05 cm(2)) and at the inferior turbinate level 0.83+/-0.05 cm(2) (normal value =0.4+/-0.04 cm(2); P<0.001); the TMC average time was 27.35+/-2.21 min ( P<0.0001). Finally, for the runners, the mean MCT time was 20.56+/-2.35 min ( P<0.001). Knowing the alterations of the physiological nasal respiration is of extreme importance to develop a correct and timely therapeutic approach to be able to restore rhino-sinusal homeostasis. Athletes, in fact, need the earliest therapeutic aid in order to avoid the interference of prolonged rhino-sinusal alterations with their performance and also to avoid a more serious clinical situation concerning the inferior airways
- …