355 research outputs found
Cowhage-Induced Itch as an Experimental Model for Pruritus. A Comparative Study with Histamine-Induced Itch
Histamine is the prototypical pruritogen used in experimental itch induction. However, in most chronic pruritic diseases, itch is not predominantly mediated by histamine. Cowhage-induced itch, on the other hand, seems more characteristic of itch occurring in chronic pruritic diseases.We tested the validity of cowhage as an itch-inducing agent by contrasting it with the classical itch inducer, histamine, in healthy subjects and atopic dermatitis (AD) patients. We also investigated whether there was a cumulative effect when both agents were combined.Fifteen healthy individuals and fifteen AD patients were recruited. Experimental itch induction was performed in eczema-free areas on the volar aspects of the forearm, using different itch inducers: histamine, cowhage and their combination thereof. Itch intensity was assessed continuously for 5.5 minutes after stimulus application using a computer-assisted visual analogue scale (COVAS).In both healthy and AD subjects, the mean and peak intensity of itch were higher after the application of cowhage compared to histamine, and were higher after the combined application of cowhage and histamine, compared to histamine alone (p<0.0001 in all cases). Itch intensity ratings were not significantly different between healthy and AD subjects for the same itch inducer used; however AD subjects exhibited a prolonged itch response in comparison to healthy subjects (p<0.001).Cowhage induced a more intense itch sensation compared to histamine. Cowhage was the dominant factor in itch perception when both pathways were stimulated in the same time. Cowhage-induced itch is a suitable model for the study of itch in AD and other chronic pruritic diseases, and it can serve as a new model for testing antipruritic drugs in humans
Pupillary anomaly masquerading as a glaucomatous visual field defect: a case report
BACKGROUND: Patients are often referred to ophthalmologists with focal visual field defects on routine testing, possibly related to a potential diagnosis of glaucoma. However, examination of the individual patient's ocular characteristics as well as facial characteristics may often reveal a cause of the visual field defect. CASE PRESENTATION: We describe a patient who was found to have a superior visual field defect on routine testing by the optician. Repeat perimetry with pharmacological dilatation of the pupil revealed that the cause of the field defect was related to an eccentric inferiorly displaced pupil, secondary to trauma some years previously. DISCUSSION: Individual patient characteristics, including both ocular, as well as facial, need to be considered, when interpreting any visual field defect
Characterization of ion/electron beam induced deposition of electrical contacts at the sub-{\mu}m scale
We investigate the fabrication of electrical contacts using ion- and
electron-beam induced deposition of platinum at the sub-\mu m scale. Halos
associated with the metal surface decoration are characterized electrically in
the 0.05-2 \mu m range using transport measurements, conducting atomic force
microscopy and Kelvin probe microscopy. In contrast with IBID, EBID electrodes
exhibit weakly conductive halos at the sub-\mu m scale, and can thus be used to
achieve resist-free electrical contacts for transport measurements at the
sub-\mu m scale. Four-point transport measurements using \mu m-spaced EBID
contacts are provided in the case of a multiwalled carbon nanotube
Statistical Reconstruction of Qutrits
We discuss a procedure of measurement followed by the reproduction of the
quantum state of a three-level optical system - a frequency- and spatially
degenerate two-photon field. The method of statistical estimation of the
quantum state based on solving the likelihood equation and analyzing the
statistical properties of the obtained estimates is developed. Using the root
approach of estimating quantum states, the initial two-photon state vector is
reproduced from the measured fourth moments in the field . The developed
approach applied to quantum states reconstruction is based on the amplitudes of
mutually complementary processes. Classical algorithm of statistical estimation
based on the Fisher information matrix is generalized to the case of quantum
systems obeying Bohr's complementarity principle. It has been experimentally
proved that biphoton-qutrit states can be reconstructed with the fidelity of
0.995-0.999 and higher.Comment: Submitted to Physical Review
Generation of a wave packet tailored to efficient free space excitation of a single atom
We demonstrate the generation of an optical dipole wave suitable for the
process of efficiently coupling single quanta of light and matter in free
space. We employ a parabolic mirror for the conversion of a transverse beam
mode to a focused dipole wave and show the required spatial and temporal
shaping of the mode incident onto the mirror. The results include a proof of
principle correction of the parabolic mirror's aberrations. For the application
of exciting an atom with a single photon pulse we demonstrate the creation of a
suitable temporal pulse envelope. We infer coupling strengths of 89% and
success probabilities of up to 87% for the application of exciting a single
atom for the current experimental parameters.Comment: to be published in Europ. Phys. J.
Entanglement-enhanced probing of a delicate material system
Quantum metrology uses entanglement and other quantum effects to improve the
sensitivity of demanding measurements. Probing of delicate systems demands high
sensitivity from limited probe energy and has motivated the field's key
benchmark-the standard quantum limit. Here we report the first
entanglement-enhanced measurement of a delicate material system. We
non-destructively probe an atomic spin ensemble by means of near-resonant
Faraday rotation, a measurement that is limited by probe-induced scattering in
quantum-memory and spin-squeezing applications. We use narrowband,
atom-resonant NOON states to beat the standard quantum limit of sensitivity by
more than five standard deviations, both on a per-photon and per-damage basis.
This demonstrates quantum enhancement with fully realistic loss and noise,
including variable-loss effects. The experiment opens the way to ultra-gentle
probing of single atoms, single molecules, quantum gases and living cells.Comment: 7 pages, 8 figures; Nature Photonics, advance online publication, 16
December 201
Heralded single photon absorption by a single atom
The emission and absorption of single photons by single atomic particles is a
fundamental limit of matter-light interaction, manifesting its quantum
mechanical nature. At the same time, as a controlled process it is a key
enabling tool for quantum technologies, such as quantum optical information
technology [1, 2] and quantum metrology [3, 4, 5, 6]. Controlling both emission
and absorption will allow implementing quantum networking scenarios [1, 7, 8,
9], where photonic communication of quantum information is interfaced with its
local processing in atoms. In studies of single-photon emission, recent
progress includes control of the shape, bandwidth, frequency, and polarization
of single-photon sources [10, 11, 12, 13, 14, 15, 16, 17], and the
demonstration of atom-photon entanglement [18, 19, 20]. Controlled absorption
of a single photon by a single atom is much less investigated; proposals exist
but only very preliminary steps have been taken experimentally such as
detecting the attenuation and phase shift of a weak laser beam by a single atom
[21, 22], and designing an optical system that covers a large fraction of the
full solid angle [23, 24, 25]. Here we report the interaction of single
heralded photons with a single trapped atom. We find strong correlations of the
detection of a heralding photon with a change in the quantum state of the atom
marking absorption of the quantum-correlated heralded photon. In coupling a
single absorber with a quantum light source, our experiment demonstrates
previously unexplored matter-light interaction, while opening up new avenues
towards photon-atom entanglement conversion in quantum technology.Comment: 10 pages, 4 figure
Clinicians' caseload management behaviours as explanatory factors in patients' length of time on caseloads : a predictive multilevel study in paediatric community occupational therapy
Peer reviewedPublisher PD
Quantum Computing and Quantum Simulation with Group-II Atoms
Recent experimental progress in controlling neutral group-II atoms for
optical clocks, and in the production of degenerate gases with group-II atoms
has given rise to novel opportunities to address challenges in quantum
computing and quantum simulation. In these systems, it is possible to encode
qubits in nuclear spin states, which are decoupled from the electronic state in
the S ground state and the long-lived P metastable state on the
clock transition. This leads to quantum computing scenarios where qubits are
stored in long lived nuclear spin states, while electronic states can be
accessed independently, for cooling of the atoms, as well as manipulation and
readout of the qubits. The high nuclear spin in some fermionic isotopes also
offers opportunities for the encoding of multiple qubits on a single atom, as
well as providing an opportunity for studying many-body physics in systems with
a high spin symmetry. Here we review recent experimental and theoretical
progress in these areas, and summarise the advantages and challenges for
quantum computing and quantum simulation with group-II atoms.Comment: 11 pages, 7 figures, review for special issue of "Quantum Information
Processing" on "Quantum Information with Neutral Particles
An SU(N) Mott insulator of an atomic Fermi gas realized by large-spin Pomeranchuk cooling
The Hubbard model, containing only the minimum ingredients of nearest
neighbor hopping and on-site interaction for correlated electrons, has
succeeded in accounting for diverse phenomena observed in solid-state
materials. One of the interesting extensions is to enlarge its spin symmetry to
SU(N>2), which is closely related to systems with orbital degeneracy. Here we
report a successful formation of the SU(6) symmetric Mott insulator state with
an atomic Fermi gas of ytterbium (173Yb) in a three-dimensional optical
lattice. Besides the suppression of compressibility and the existence of charge
excitation gap which characterize a Mott insulating phase, we reveal an
important difference between the cases of SU(6) and SU(2) in the achievable
temperature as the consequence of different entropy carried by an isolated
spin. This is analogous to Pomeranchuk cooling in solid 3He and will be helpful
for investigating exotic quantum phases of SU(N) Hubbard system at extremely
low temperatures.Comment: 20 pages, 6 figures, to appear in Nature Physic
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