9 research outputs found
Histopathological evaluation of recurrent goiter.
The recurrent goiter is the regrowth of thyroid tissue after thyroidectomy. An inadequate surgical removal of the thyroid gland, lack of substitution therapy and pathological stimulation of the thyroid growth can all promote the recurrence. The aim of this study was to find the connection between the histopathological findings during the first and second operation and the recurrence of goiter. The study group consisted of 29 women and 1 man. The mean time to recurrence was 15 years. The most frequent histopathological finding during the first and second operation was struma nodosa. According to our observations different histopathological findings were found in 63.4% cases after primary and secondary thyroidectomy. Some genetic investigations showed that nodules in recurrent goiters did not derive from nodules left during the first operation but from a group of cells which had high growth potential. Thus, not only the operation technique and substitution after operation are key factors of successful therapy of goiter, but also other factors which stimulate the re-growth of thyroid tissue
Influence of acetylsalicylic acid on hematotoxicity of benzene
Objectives: The aim of the study was to evaluate the influence of acetylsalicylic acid (ASA) on benzene hematotoxicity in rats. Materials and Methods: The study was carried out on rats exposed for 2, 4 and 8 weeks to benzene vapour at a conentration of 1.5 or 4.5 mmol/m3 of air (5 days per week, 6 hours per day) alone or together with ASA at the doses of 5, 150 or 300 mg/kg body weight (per os). Results: Benzene at a concentration of 4.5 mmol/m3 caused a slight lymphopenia, granulocytosis and reticulocytosis in blood. In bone marrow traits of megaloblastic renewal, presence of undifferentiated cells and giant forms of granulocytes as well as an increase in myeloperoxidase and decrease in chloroacetate esterase activity and lipids content were noted. ASA (150 and 300 mg/kg b.w.) influenced some of hematological parameters, altered by benzene intoxication. ASA limited the solvent-induced alteration in blood reticulocyte count and in the case of bone marrow in the erythroblasts count. Traits of megaloblastic renewal in bone marrow were less pronounced. Besides, higher activity of myeloperoxidase and the decrease in the level of lipids in granulocytes were noted. Conclusion: Our results suggest that ASA limited the benzene-induced hematotoxicity
The project of rehabilitation devices for people with the proprioceptive dysfunction
W pracy przedstawiono projekt urzÄ
dzeĆ do reedukacji osĂłb z zaburzeniami propriocepcji. Prace projektowe zostaĆy wykonane w programie Inventor 2009. Z uwagi na znaczenie takich urzÄ
dzeĆ w rehabilitacji, ich konstrukcje cechujÄ
siÄ wielofunkcyjnoĆciÄ
. Dla zapewnienia bezpieczeĆstwa uĆŒytkownikĂłw zostaĆa przeprowadzona analiza wytrzymaĆoĆciowa elementĂłw skĆadowych najbardziej naraĆŒonych na uszkodzenie w programie Ansys Workbench. Otrzymane wyniki z obliczeĆ potwierdziĆy poprawnoĆÄ przyjÄtych zaĆoĆŒeĆ projektowych i dobranych parametrĂłw konstrukcyjnych urzÄ
dzeĆ.The project of rehabilitation devices for people with the proprioceptive disorder was presented in this paper. Development of the multifunctional devices was made using Inventor 2009. Usefulness of the devices construction was found on the base of strength analysis using Ansys Workbench. Obtained results testified correct choice of project assumption data
Occurrence of heavy metals, sodium, calcium, and potassium in human hair, teeth, and nails
Carbon-13 longitudinal relaxation time measurements and DFT-GIAO NMR computations for two ammonium ions of a tetraazamacrocyclic scorpiand system
Spin-lattice relaxation times, T1s, for 13C nuclei in two cations Hn1n+ (n
= 1, 5)of N-(2-amino-ethyl)-cyclam (1, scorpiand) were determined by means
of 13C{1H} NMR experiments in aqueous solution at pH 11.5 and 0.2. The
theoretical study [modeling with OPLS-AA, B3LYP/6-31G(d) geometry
optimizations, dispersion-corrected energies (DFT-D3), and DFT-GIAO
predictions of the NMR chemical shifts (including an IEF-PCM simulation of
hydration)] was also done for several conformers of the tautomer iso-H414+
not investigated before. The binding directions in protonated polyamino
receptors necessary for efficient complexation of the nitrate anion(s)
were briefly outlined, as well. All these results were discussed in terms
of 'abnormal' 13C chemical shift changes found previously for the
side-chain carbons of amine 1 in strongly acidic solution (HNO3). In
conclusion, an earlier proposal of its association with NO3- at pH=1 was
rejected. Instead, the participation of small amounts of a microspecies
iso-H414+Dhydr under such conditions can be proposed.Publikacja w ramach programu Springer Open Choice/Open Access finansowanego przez Ministerstwo Nauki i Szkolnictwa WyĆŒszego i realizowanego w ramach umowy na narodowÄ
licencjÄ akademickÄ
na czasopisma Springer w latach 2010-2013
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
AimThe SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery.MethodsThis was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4âweeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin.ResultsOverall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4âweeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, PÂ =Â 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, PâConclusionOne in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease