Timing of N application affects winter cereal production

Non-Peer Reviewe

Redressing the balance: Commentary on “Examining motor learning in older adults using analogy instruction” by Tse, Wong, and Masters (2017)

Tse, Wong, and Masters (2017) recently published a study that indicated that analogy instruction may help older adults acquire resilient motor skills that require reduced cognitive processing compared to traditional explicit instruction. Although we do not dispute that analogy learning may prove useful for this population, in this commentary, we contend that there are methodological issues in this research—which are shared with previous studies comparing analogy and explicit instruction—that potentially limit ecological validity, impact the size of detected effects, influence the development and understanding of associated theory, and, as such, constrain resulting recommendations for applied practice. Of particular concern is the comparison of the single-item analogy instruction to the list of nine explicit instructions, which risks conflating the effects of the type of instruction with the volume of instruction. We further argue that the benefits of analogy may be more parsimoniously explained by the instruction’s capability to succinctly convey skill (rather than its potential for limiting reinvestment), but that this capability may only be realised if the to-be-learned analogy is relevant and readily understood by the learner. Finally, we suggest that research in this area must look to incorporate more rigorous methods that compare experimental conditions to representative reference groups that allow us to explore how and when to deploy the myriad instructional tools available to practitioners and learners

Cropping diversity and input use affect weed competition

Non-Peer ReviewedOf the various pests affecting crop growth weeds are among the most visible and potentially the most damaging. Changing markets, higher input costs and technological change are having a profound impact on weed management decisions in Western Canada. While the decision to change management practices can be immediate the long term agronomic consequences of adopting a farm management system are not well understood. One objective of a long term study, established at Scott in 1995, was to investigate the impact of 3 levels of inputs and 3 levels of cropping diversity on in-crop weed competition. Weed biomass used as an indicator of weed competition, was found to be largely a function of input level decisions and the interaction of weed control operations with precipitation timing. Greater weed biomass in an Organic input system could be linked to a limited number of early season tillage operations occurring over a short window of opportunity near the time of seeding. Herbicides applied later in the growing season in the Reduced and High input system effectively delayed weed growth and reduced weed biomass. Weeds in the Organic input system tended to respond to June-July precipitation while weed growth in the Reduced and High input system increased as July precipitation increased. Differences between cropping diversities were less pronounced showing similar weed biomass trends over time

Input level and crop diversity effects on nitrate-N, extractable P, aggregation, and organic C and N in soil after two 6-year crop rotation cycles

Non-Peer Reviewe

Impact of crop management systems on Fusarium populations in spring wheat and barley on the Canadian prairies

Non-Peer Reviewe

A re-appraisal of the reliability of the 20 m multi-stage shuttle run test

This is the author's PDF version of an article published in European journal of applied physiology in 2007. The original publication is available at www.springerlink.co

Accuracy and Efficiency of Recording Pediatric Early Warning Scores Using an Electronic Physiological Surveillance System Compared With Traditional Paper-Based Documentation

Pediatric Early Warning Scores are advocated to assist health professionals to identify early signs of serious illness or deterioration in hospitalized children. Scores are derived from the weighting applied to recorded vital signs and clinical observations reflecting deviation from a predetermined "norm." Higher aggregate scores trigger an escalation in care aimed at preventing critical deterioration. Process errors made while recording these data, including plotting or calculation errors, have the potential to impede the reliability of the score. To test this hypothesis, we conducted a controlled study of documentation using five clinical vignettes. We measured the accuracy of vital sign recording, score calculation, and time taken to complete documentation using a handheld electronic physiological surveillance system, VitalPAC Pediatric, compared with traditional paper-based charts. We explored the user acceptability of both methods using a Web-based survey. Twenty-three staff participated in the controlled study. The electronic physiological surveillance system improved the accuracy of vital sign recording, 98.5% versus 85.6%, P < .02, Pediatric Early Warning Score calculation, 94.6% versus 55.7%, P < .02, and saved time, 68 versus 98 seconds, compared with paper-based documentation, P < .002. Twenty-nine staff completed the Web-based survey. They perceived that the electronic physiological surveillance system offered safety benefits by reducing human error while providing instant visibility of recorded data to the entire clinical team

Enhancing the efficacy of glycolytic blockade in cancer cells via RAD51 inhibition.

Targeting the early steps of the glycolysis pathway in cancers is a well-established therapeutic strategy; however, the doses required to elicit a therapeutic effect on the cancer can be toxic to the patient. Consequently, numerous preclinical and clinical studies have combined glycolytic blockade with other therapies. However, most of these other therapies do not specifically target cancer cells, and thus adversely affect normal tissue. Here we first show that a diverse number of cancer models - spontaneous, patient-derived xenografted tumor samples, and xenografted human cancer cells - can be efficiently targeted by 2-deoxy-D-Glucose (2DG), a well-known glycolytic inhibitor. Next, we tested the cancer-cell specificity of a therapeutic compound using the MEC1 cell line, a chronic lymphocytic leukemia (CLL) cell line that expresses activation induced cytidine deaminase (AID). We show that MEC1 cells, are susceptible to 4,4\u27-Diisothiocyano-2,2\u27-stilbenedisulfonic acid (DIDS), a specific RAD51 inhibitor. We then combine 2DG and DIDS, each at a lower dose and demonstrate that this combination is more efficacious than fludarabine, the current standard- of- care treatment for CLL. This suggests that the therapeutic blockade of glycolysis together with the therapeutic inhibition of RAD51-dependent homologous recombination can be a potentially beneficial combination for targeting AID positive cancer cells with minimal adverse effects on normal tissue. IMPLICATIONS: Combination therapy targeting glycolysis and specific RAD51 function shows increased efficacy as compared to standard of care treatments in leukemias