Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing.

Deposition of potentially neurotoxic Aβ fragments derived from amyloid precursor protein (APP) at synapses may be a key contributor to Alzheimer's disease. However, the location(s) of proteolytic processing and subsequent secretion of APP fragments from highly compartmentalized, euploid neurons that express APP and processing enzymes at normal levels is not well understood. To probe the behavior of endogenous APP, particularly in human neurons, we developed a system using neurons differentiated from human embryonic stem cells, cultured in microfluidic devices, to enable direct biochemical measurements from axons. Using human or mouse neurons in these devices, we measured levels of Aβ, sAPPα, and sAPPβ secreted solely from axons. We found that a majority of the fragments secreted from axons were processed in the soma, and many were dependent on somatic endocytosis for axonal secretion. We also observed that APP and the β-site APP cleaving enzyme were, for the most part, not dependent on endocytosis for axonal entry. These data establish that axonal entry and secretion of APP and its proteolytic processing products traverse different pathways in the somatodendritic compartment before axonal entry

Extended two-level quantum dissipative system from bosonization of the elliptic spin-1/2 Kondo model

We study the elliptic spin-1/2 Kondo model (spin-1/2 fermions in one dimension with fully anisotropic contact interactions with a magnetic impurity) in the light of mappings to bosonic systems using the fermion-boson correspondence and associated unitary transformations. We show that for fixed fermion number, the bosonic system describes a two-level quantum dissipative system with two noninteracting copies of infinitely-degenerate upper and lower levels. In addition to the standard tunnelling transitions, and the transitions driven by the dissipative coupling, there are also bath-mediated transitions between the upper and lower states which simultaneously effect shifts in the horizontal degeneracy label. We speculate that these systems could provide new examples of continuous time quantum random walks, which are exactly solvable.Comment: 7 pages, 1 figur

Stability Properties of Strongly Magnetized Spine Sheath Relativistic Jets

The linearized relativistic magnetohydrodynamic (RMHD) equations describing a uniform axially magnetized cylindrical relativistic jet spine embedded in a uniform axially magnetized relativistically moving sheath are derived. The displacement current is retained in the equations so that effects associated with Alfven wave propagation near light speed can be studied. A dispersion relation for the normal modes is obtained. Analytical solutions for the normal modes in the low and high frequency limits are found and a general stability condition is determined. A trans-Alfvenic and even a super-Alfvenic relativistic jet spine can be stable to velocity shear driven Kelvin-Helmholtz modes. The resonance condition for maximum growth of the normal modes is obtained in the kinetically and magnetically dominated regimes. Numerical solution of the dispersion relation verifies the analytical solutions and is used to study the regime of high sound and Alfven speeds.Comment: 42 pages includes 7 figures, to appear in Ap

Confirmation of a cluster of galaxies hidden behind the Galactic bulge using the VVV Survey

Suzaku and Chandra X-ray observations detected a new cluster of galaxies, Suzaku J1759-3450, at a redshift z=0.13. It is located behind the Milky Way, and the high Galactic dust extinction renders it nearly invisible at optical wavelengths. We attempt here to confirm the galaxy cluster with near-infrared imaging observations, and to characterize its central member galaxies. Images from the VVV survey were used to detect candidate member galaxies of Suzaku J1759-3450 within the central region of the cluster, up to 350 kpc from the X-ray peak emission. Color-magnitude and color-color diagrams and morphology criteria allowed us to select the galaxies among the numerous foreground sources. Fifteen candidate cluster members were found very close to a modeled red-sequence at the redshift of the cluster. Five members are extremely bright, and one is possibly a cD galaxy. The asymmetry in the spatial distribution of the galaxies respect to the X-ray peak emission is an indicator of that this cluster is still suffering a virialization process. Our investigation of Suzaku J1759-3450 demonstrates the potential of the VVV Survey to study the hidden population of galaxies in the Zone of Avoidance.Comment: 7 pages, 5 figures. Accepted for Publication in Astronomy & Astrophysic

Comparison between homogeneous and heterogeneous field information for plastic material identification

peer reviewedThe accuracy of a Finite Element Simulation for plastic deformation strongly depends on the chosen constitutive laws and the value of the material parameters within these laws. The identification of those mechanical parameters can be done based on homogeneous stress and strain fields such as those obtained in uniaxial tensile tests and simple shear tests performed in different plane material directions. Another way to identify plastic material parameters is by inverse modeling of an experiment exhibiting a heterogeneous stress and strain field. Experimental forces and strains are in this case compared to the simulated ones and it is tried to reduce the difference in a least-squares sense by optimizing the model parameters. The optimization technique used is this case is gradient based, which means that at every iteration a sensitivity calculation has to be performed in order to indicate the direction in which the parameters are to be identified. The basic principle of the inverse modeling procedure as it is used for parameter identification is the generation of a complex and heterogeneous deformation field that contains as much information as possible about the parameters to be identified. One way of obtaining such a non-homogeneous deformation is by altering the geometry of the specimen for a uniaxial test. Another possibility is to make the loading conditions more complex. In this paper both options are actually combined by using a biaxial tensile test on a perforated cruciform specimen. In the present paper, the work hardening of the material is assumed to be isotropic and it is described by a Swift law. The yield locus is modeled by the anisotropic Hill48 criterion. A comparison is made between the identification of the Hill48 parameters based on the one hand on the Lankford coefficients [1] and on the inverse modeling of a biaxial tensile test on the other han

Magnetic Field Generation in Core-Sheath Jets via the Kinetic Kelvin-Helmholtz Instability

We have investigated magnetic field generation in velocity shears via the kinetic Kelvin-Helmholtz instability (kKHI) using a relativistic plasma jet core and stationary plasma sheath. Our three-dimensional particle-in-cell simulations consider plasma jet cores with Lorentz factors of 1.5, 5, and 15 for both electron-proton and electron-positron plasmas. For electron-proton plasmas we find generation of strong large-scale DC currents and magnetic fields which extend over the entire shear-surface and reach thicknesses of a few tens of electron skin depths. For electron-positron plasmas we find generation of alternating currents and magnetic fields. Jet and sheath plasmas are accelerated across the shear surface in the strong magnetic fields generated by the kKHI. The mixing of jet and sheath plasmas generates transverse structure similar to that produced by the Weibel instability.Comment: 28 pages, 12 figures, in press, ApJ, September 10, 201

Coaxial Jets and Sheaths in Wide-Angle-Tail Radio Galaxies

We add 20, 6 and 3.6 cm wavelength VLA observations of two WATs, 1231+674 and 1433+553, to existing VLA data at 6 and 20 cm, in order to study the variations of spectral index as a function of position. We apply the spectral tomography process that we introduced in our analysis of 3C67, 3C190 and 3C449. Both spectral tomography and polarization maps indicate that there are two distinct extended components in each source. As in the case of 3C449, we find that each source has a flat spectrum jet surrounded by a steeper spectrum sheath. The steep components tend to be more highly polarized than the flat components. We discuss a number of possibilities for the dynamics of the jet/sheath systems, and the evolution of their relativistic electron populations. While the exact nature of these two coaxial components is still uncertain, their existence requires new models of jets in FR I sources and may also have implications for the dichotomy between FR Is and FR IIs.Comment: 29 text pages plus 13 figures. Scheduled for publication in May 10, 1999 Ap