Assessment of the health and psychological status of the population in the conditions of the COVID – 19 pandemic

The aim of the study – to assess the health and psychological status of the populationЦель исследования – оценка состояния здоровья и психологического статуса населени

Non-ionising electromagnetic radiation, health effects and protective measures

The aim of the study – to study aspects of public awareness of the dangers of non-ionizing electromagnetic radiation, as well as its effects on the human body.Цель исследования – изучение аспектов информированности населения об опасности неионизирующих электромагнитных излучений, а также их влияния на организм человек

Supramolecular thermoplastics and thermoplastic elastomer materials with self-healing ability based on oligomeric charged triblock copolymers

Supramolecular polymeric materials constitute a unique class of materials held together by non-covalent interactions. These dynamic supramolecular interactions can provide unique properties such as a strong decrease in viscosity upon relatively mild heating, as well as self-healing ability. In this study we demonstrate the unique mechanical properties of phase-separated electrostatic supramolecular materials based on mixing of low molar mass, oligomeric, ABA-triblock copolyacrylates with oppositely charged outer blocks. In case of well-chosen mixtures and block lengths, the charged blocks are phase separated from the uncharged matrix in a hexagonally packed nanomorphology as observed by transmission electron microscopy. Thermal and mechanical analysis of the material shows that the charged sections have a T-g closely beyond room temperature, whereas the material shows an elastic response at temperatures far above this T-g ascribed to the electrostatic supramolecular interactions. A broad set of materials having systematic variations in triblock copolymer structures was used to provide insights in the mechanical properties and and self-healing ability in correlation with the nanomorphology of the materials

G-arylated hydrogen-bonded cyclic tetramer assemblies with remarkable thermodynamic and kinetic stability

The preparation and self-assembly of novel G-C dinucleoside monomers that are equipped with electron-poor aryl groups at the G-N2 amino group have been studied. Such monomers associate via Watson-Crick H-bonding into discrete unstrained tetrameric macrocycles that arise as a thermodynamically and kinetically stabilized product in a wide variety of experimental conditions, including very polar solvent environments and low concentrations. G-arylation produces an increased stability of the cyclic assembly, as a result of a subtle interplay between enthalpic and entropic effects involving the solvent coordination sphereFunding from the European Research Council (ERC-StG 279548) and MINECO (CTQ2011-23659) is gratefully acknowledge

The cost-effectiveness of procalcitonin for guiding antibiotic prescribing in individuals hospitalized with COVID-19: part of the PEACH study

Background Many hospitals introduced procalcitonin (PCT) testing to help diagnose bacterial coinfection in individuals with COVID-19, and guide antibiotic decision-making during the COVID-19 pandemic in the UK. Objectives Evaluating cost-effectiveness of using PCT to guide antibiotic decisions in individuals hospitalized with COVID-19, as part of a wider research programme. Methods Retrospective individual-level data on patients hospitalized with COVID-19 were collected from 11 NHS acute hospital Trusts and Health Boards from England and Wales, which varied in their use of baseline PCT testing during the first COVID-19 pandemic wave. A matched analysis (part of a wider analysis reported elsewhere) created groups of patients whose PCT was/was not tested at baseline. A model was created with combined decision tree/Markov phases, parameterized with quality-of-life/unit cost estimates from the literature, and used to estimate costs and quality-adjusted life years (QALYs). Cost-effectiveness was judged at a £20 000/QALY threshold. Uncertainty was characterized using bootstrapping. Results People who had baseline PCT testing had shorter general ward/ICU stays and spent less time on antibiotics, though with overlap between the groups’ 95% CIs. Those with baseline PCT testing accrued more QALYs (8.76 versus 8.62) and lower costs (£9830 versus £10 700). The point estimate was baseline PCT testing being dominant over no baseline testing, though with uncertainty: the probability of cost-effectiveness was 0.579 with a 1 year horizon and 0.872 with a lifetime horizon. Conclusions Using PCT to guide antibiotic therapy in individuals hospitalized with COVID-19 is more likely to be cost-effective than not, albeit with uncertainty

Origins of philosophical and mythological conception of count Uvarov

The article is dedicated to European intellectual context on the edge of 18-19 centuries, particularly to the discovery of East by Europe, transfer to romantic paradigm of mentality; as well as to formation of philosophical and mythological views of count Sergey Semenovich Uvarov, whose work is inseparably connected to this context

The Philosophical Bases of the Pedagogical Views of V. F. Odoyevsky

The paper unveils the interrelationship existing between V. F. Odoyevsky's pedagogy and his philosophical ideas. The philosophical and pedagogical legacy of the thinker is of a considerable interest as one of the most developed in the history of Russian thought in the first half of the 19th century in the models for the construction of a program of education in the wake of the romantic 'organicistic' education. The author demonstrates that the pedagogical dominant in Odoyevsky's philosophical worldview forms very early; the analysis of the development of his philosophical views since the 1820s reveals an intrinsic link between the pedagogical orientation of his mindset and the philosophical reflection on cultural, linguistic and knowledge issues. This link is also maintained in the works of the 1830s and 1840s, when Odoyevsky's observations in the field of theory and practice of education become isolated in a disciplinary sense from the philosophical corpus of his ideas