New directions in EEG measurement: an investigation into the fidelity of electrical potential sensor signals

Low frequency noise performance is the key indicator in determining the signal to noise ratio of a capacitively coupled sensor when used to acquire electroencephalogram signals. For this reason, a prototype Electric Potential Sensor device based on an auto-zero operational amplifier has been developed and evaluated. The absence of 1/f noise in these devices makes them ideal for use with signal frequencies ~10 Hz or less. The active electrodes are designed to be physically and electrically robust and chemically and biochemically inert. They are electrically insulated (anodized) and have diameters of 12 mm or 18 mm. In both cases, the sensors are housed in inert stainless steel machined housings with the electronics fabricated in surface mount components on a printed circuit board compatible with epoxy potting compounds. Potted sensors are designed to be immersed in alcohol for sterilization purposes. A comparative study was conducted with a commercial wet gel electrode system. These studies comprised measurements of both free running electroencephalogram and Event Related Potentials. Quality of the recorded electroencephalogram was assessed using three methods of inspection of raw signal, comparing signal to noise ratios, and Event Related Potentials noise analysis. A strictly comparable signal to noise ratio was observed and the overall conclusion from these comparative studies is that the noise performance of the new sensor is appropriate

Impact of DM direct searches and the LHC analyses on branon phenomenology

Dark Matter direct detection experiments are able to exclude interesting parameter space regions of particle models which predict an important amount of thermal relics. We use recent data to constrain the branon model and to compute the region that is favored by CDMS measurements. Within this work, we also update present colliders constraints with new studies coming from the LHC. Despite the present low luminosity, it is remarkable that for heavy branons, CMS and ATLAS measurements are already more constraining than previous analyses performed with TEVATRON and LEP data.Comment: 17 pages, 2 figure

Interleukin-17/Interleukin-17 Receptor-Mediated Signaling Is Important for Generation of an Optimal Polymorphonuclear Response against Toxoplasma gondii Infection

We investigated the role of interleukin-17 (IL-17)/IL-17 receptor (IL-17R)-mediated signaling in the protective immunity against Toxoplasma gondii. IL-17R−/− mice developed a normal adaptive immunity against the parasite. However, increased mortality in the knockout animals can be attributed to a defect in the migration of polymorphonuclear leukocytes to infected sites during early infection

A Dichotomous Role for Nitric Oxide During Acute Toxoplasma gondii Infection in Mice

Production of nitric oxide by macrophages is believed to be an important microbicidal mechanism for a variety of intracellular pathogens, including Toxoplasma gondii. Mice with a targeted disruption of the inducible nitric oxide synthase gene (iNOS) were infected orally with T. gondii tissue cysts. Time to death was prolonged compared with parental controls. Histologic analysis of tissue from infected mice showed scattered small foci of inflammation with parasites in various tissues of iNOS−/− mice, whereas tissue from the parental C57BL/6 mice had more extensive tissue inflammation with few visible parasites. In particular, extensive ulceration and necrosis of distal small intestine and fatty degeneration of the liver was seen in the parental mice at day 7 postinfection, as compared with the iNOS−/− mice where these tissues appeared normal. Serum interferon γ and tumor necrosis factor α levels postinfection were equally elevated in both mouse strains. Treatment of the parental mice with a NO synthase inhibitor, aminoguanidine, prevented early death in these mice as well as the hepatic degeneration and small bowel necrosis seen in acutely infected control parentals. These findings indicate that NO production during acute infection with T. gondii can kill intracellular parasites but can be detrimental, even lethal, to the host

Response of VIRGO detectors to pre-big-bang gravitons

The sensitivity achievable by a pair of VIRGO detectors to stochastic and isotropic gravitational wave backgrounds produced in pre-big-bang models is discussed in view of the development of a second VIRGO interferometer. We describe a semi-analytical technique allowing to compute the signal-to-noise ratio for (monotonic or non-monotonic) logarithmic energy spectra of relic gravitons of arbitrary slope. We apply our results to the case of two correlated and coaligned VIRGO detectors and we compute their achievable sensitivities. We perform our calculations both for the usual case of minimal string cosmological scenario and in the case of a non-minimal scenario where a long dilaton dominated phase is present prior to the onset of the ordinary radiation dominated phase. In this framework, we investigate possible improvements of the achievable sensitivities by selective reduction of the thermal contributions (pendulum and pendulum's internal modes) to the noise power spectra of the detectors. Since a reduction of the shot noise does not increase significantly the expected sensitivity of a VIRGO pair (in spite of the relative spatial location of the two detectors) our findings support the experimental efforts directed towards a substantial reduction of thermal noise.Comment: 23 pages in Latex styl

Are heterotrophic and silica-rich eukaryotic microbes an important part of the lichen symbiosis?

We speculate that heterotrophic and/or silica-rich eukaryotic microorganisms maybe an important part of the lichen symbiosis. None of the very few studies of heterotrophic protists associated with lichens have considered the possibility that they may be of functional significance in the lichen symbiosis. Here we start to develop, currently speculative, theoretical ideas about their potential significance. For example, all the protist taxa identified in lichens we sampled in Ohio USA depend on silica for growth and construction of their cell walls, this could suggest that silica-rich lichen symbionts may be significant in the biogeochemistry of the lichen symbiosis. We also present arguments suggesting a role for protists in nitrogen cycling within lichen thalli and a potential role in controlling bacterial populations associated with lichens. In this necessarily speculative paper we highlight areas for future research and how newer technologies may be useful for understanding the full suite of organisms involved in the lichen symbiosis. Keywords: lichens; protists; symbiosis; testate amoebae; diatom; chrysophyt

Exploring multiple steady states in Earth's long-term carbon cycle

The long-term carbon cycle regulates Earth's climate and atmospheric CO2 levels over multimillion-year timescales, but it is not clear that this system has a single steady state for a given input rate of CO2. In this paper we explore the possibility for multiple steady states in the long-term climate system. Using a simple carbon cycle box model, we show that the location of precipitation bands around the tropics and high mid-latitudes, coupled with the response of the terrestrial biosphere to local surface temperature, can result in system bi-stability. Here, maximum CO2 drawdown can occur when either the tropics or high mid-latitudes are at the photosynthetic optimum temperature of around 25°C, and a period of instability can exist between these states. We suggest that this dynamic has influenced climate variations over Phanerozoic time, and that higher steady state surface temperatures may be easier to reach than is commonly demonstrated in simple ‘GEOCARB style’ carbon cycle models