The Suggested Activities for Use in the Development of a Curriculum Guide for the Educable Mentally Retarded at the Primary, Intermediate, and Secondary Levels

It is the purpose of this study to suggest activities for use in a curriculum guide for the educable mentally retarded in physical education at the primary, intermediate, and secondary levels

MOCVD growth of Bi2Te3-Sb2Te3 layers : Effect of growth parameters on the electrical and thermoelectrical properties

The growth of (Bi1-xSbx)2Te3 thin films by metal-organic chemical vapour deposition (MOCVD) using trimethylbismuth, triethylantimony and diethyltellurium as bismuth, antimony and tellurium sources respectively is investigated on pyrex substrates. The electrical and thermoelectrical properties of this material are also measured over the growth temperature range 360-470°C. The studies are also made on the effect of VI/V ratio on these properties in the variation range 2-9. Polycrystalline structure is confirmed by X-ray diffraction, and it is observed that the intensity of the preferred orientation is higher at 450°C. The measurement of Seebeck coefficient shows that all samples have p-type conduction. The best value of this parameter is obtained for high growth temperature (240µV/K). The good result obtained for (Bi1-xSbx)2Te3 thin films revealed the great potential of MOCVD method which is an industrial technique to produce good materials for device applications (sensors and thermopiles).The growth of (Bi1-xSbx)2Te3 thin films by metal-organic chemical vapour deposition (MOCVD) using trimethylbismuth, triethylantimony and diethyltellurium as bismuth, antimony and tellurium sources respectively is investigated on pyrex substrates. The electrical and thermoelectrical properties of this material are also measured over the growth temperature range 360-470°C. The studies are also made on the effect of VI/V ratio on these properties in the variation range 2-9. Polycrystalline structure is confirmed by X-ray diffraction, and it is observed that the intensity of the preferred orientation is higher at 450°C. The measurement of Seebeck coefficient shows that all samples have p-type conduction. The best value of this parameter is obtained for high growth temperature (240µV/K). The good result obtained for (Bi1-xSbx)2Te3 thin films revealed the great potential of MOCVD method which is an industrial technique to produce good materials for device applications (sensors and thermopiles)

End-of-fabrication CMOS process monitor

A set of test 'modules' for verifying the quality of a complementary metal oxide semiconductor (CMOS) process at the end of the wafer fabrication is documented. By electrical testing of specific structures, over thirty parameters are collected characterizing interconnects, dielectrics, contacts, transistors, and inverters. Each test module contains a specification of its purpose, the layout of the test structure, the test procedures, the data reduction algorithms, and exemplary results obtained from 3-, 2-, or 1.6-micrometer CMOS/bulk processes. The document is intended to establish standard process qualification procedures for Application Specific Integrated Circuits (ASIC's)

Challenges and Opportunities: What Can We Learn from Patients Living with Chronic Musculoskeletal Conditions, Health Professionals and Carers about the Concept of Health Literacy Using Qualitative Methods of Inquiry?

The field of health literacy continues to evolve and concern public health researchers and yet remains a largely overlooked concept elsewhere in the healthcare system. We conducted focus group discussions in England UK, about the concept of health literacy with older patients with chronic musculoskeletal conditions (mean age = 73.4 years), carers and health professionals. Our research posed methodological, intellectual and practical challenges. Gaps in conceptualisation and expectations were revealed, reiterating deficiencies in predominant models for understanding health literacy and methodological shortcomings of using focus groups in qualitative research for this topic. Building on this unique insight into what the concept of health literacy meant to participants, we present analysis of our findings on factors perceived to foster and inhibit health literacy and on the issue of responsibility in health literacy. Patients saw health literacy as a result of an inconsistent interactive process and the implications as wide ranging; healthcare professionals had more heterogeneous views. All focus group discussants agreed that health literacy most benefited from good inter-personal communication and partnership. By proposing a needs-based approach to health literacy we offer an alternative way of conceptualising health literacy to help improve the health of older people with chronic conditions

Powder blasting for the realisation of microchips for bio-analytic applications

We introduce powder blasting for the fabrication of glass microchips. Powder blasting is a fast and cheap technique with which we pattern channels in sodalime and pyrex glass with a width down to 100µm. We combine the technique with appropriate bonding procedures to realise sealed microchannel structures. We study the transport of fluorescent dye solutions and fluorescent beads within channels made by powder blasting and in "classical" channels made by HF-etching. We find a remarkable difference in sign of the electric field induced flow for both types of channels and explain the observed strong plug broadening effects in the powder blasted channels

Utilisation of the sol-gel technique for the development of novel stationary phases for capillary electrochromatography on a chip

Capillary electrochromatography (CEC) appears ideally suited for high performance separations at small scale, i.e. on a chip. Problems with the reproducible production of the required HPLC column, but also the lack of commercially available CEC instruments have prevented many putative applicants of this promising technique from entering the field. In this paper, a fast and easy way to produce self-containing open-tubular CEC columns (C8-moieties for reversed phase applications) by the sol-gel technique is described. The corresponding chips were designed to be compatible with a commercial system for capillary electrophoresis (namely a Beckman P/ACE 5500 system with diode array detection). Method development and application hence benefited from the injection and the detection options of this setup. The separation of a mixture of three uncharged analytes (polycyclic aromatic hydrocarbons) by the chip is given as example. Under optimized conditions, the performance of the chip appeared to be comparable or better than that of capillary-based CEC columns of the same kind

The association of health literacy with adherence in older 2 adults, and its role in interventions: a systematic meta-review

Background: Low health literacy is a common problem among older adults. It is often suggested to be associated with poor adherence. This suggested association implies a need for effective adherence interventions in low health literate people. However, previous reviews show mixed results on the association between low health literacy and poor adherence. A systematic meta-review of systematic reviews was conducted to study the association between health literacy and adherence in adults above the age of 50. Evidence for the effectiveness of adherence interventions among adults in this older age group with low health literacy was also explored. Methods: Eight electronic databases (MEDLINE, ERIC, EMBASE, PsycINFO, CINAHL, DARE, the Cochrane Library, and Web of Knowledge) were searched using a variety of keywords regarding health literacy and adherence. Additionally, references of identified articles were checked. Systematic reviews were included if they assessed the association between health literacy and adherence or evaluated the effectiveness of interventions to improve adherence in adults with low health literacy. The AMSTAR tool was used to assess the quality of the included reviews. The selection procedure, data-extraction, and quality assessment were performed by two independent reviewers. Seventeen reviews were selected for inclusion. Results: Reviews varied widely in quality. Both reviews of high and low quality found only weak or mixed associations between health literacy and adherence among older adults. Reviews report on seven studies that assess the effectiveness of adherence interventions among low health literate older adults. The results suggest that some adherence interventions are effective for this group. The interventions described in the reviews focused mainly on education and on lowering the health literacy demands of adherence instructions. No conclusions could be drawn about which type of intervention could be most beneficial for this population. Conclusions: Evidence on the association between health literacy and adherence in older adults is relatively weak. Adherence interventions are potentially effective for the vulnerable population of older adults with low levels of health literacy, but the evidence on this topic is limited. Further research is needed on the association between health literacy and general health behavior, and on the effectiveness of interventions

Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity

TRIMCyps are anti-retroviral proteins that have arisen independently in New World and Old World primates. All TRIMCyps comprise a CypA domain fused to the tripartite domains of TRIM5α but they have distinct lentiviral specificities, conferring HIV-1 restriction in New World owl monkeys and HIV-2 restriction in Old World rhesus macaques. Here we provide evidence that Asian macaque TRIMCyps have acquired changes that switch restriction specificity between different lentiviral lineages, resulting in species-specific alleles that target different viruses. Structural, thermodynamic and viral restriction analysis suggests that a single mutation in the Cyp domain, R69H, occurred early in macaque TRIMCyp evolution, expanding restriction specificity to the lentiviral lineages found in African green monkeys, sooty mangabeys and chimpanzees. Subsequent mutations have enhanced restriction to particular viruses but at the cost of broad specificity. We reveal how specificity is altered by a scaffold mutation, E143K, that modifies surface electrostatics and propagates conformational changes into the active site. Our results suggest that lentiviruses may have been important pathogens in Asian macaques despite the fact that there are no reported lentiviral infections in current macaque populations