A Class of Separation Axioms in Generalized Topology

The purpose of this paper is to introduce and study some new class of definitions like µ-point closure and gµ –regular space concerning generalized topological space. We obtain some characterizations and several properties of such definitions. This paper takes some investigations on generalized topological spaces with gµ –closed sets and gµ–closed sets

Spectral Continiuty : (p, k) - Quasihyponormal and Totally p-(a,b) normal operators

An operator T  B(H) is said to be P-  normal operators for  . In this paper, we prove that continuity of the set theoretic functions spectrum, Weyl spectrum, Browder spectrum and essential surjectivity spectrum on the classes consisting of (p, k)- quasihyponormal operators and totally P- operators

Drug Interaction Study Of Apixaban With Cyclosporine Or Tacrolimus: Results From A Phase 1, Randomized, Open-Label, Crossover Study In Healthy Volunteers

BACKGROUND Solid organ transplant recipients commonly require anticoagulation. Apixaban (APX) is principally metabolized by CYP3A4, undergoes direct intestinal excretion, and is a substrate to P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP) transporters. We examined the potential drug interaction between cyclosporine (CsA) and tacrolimus (Tac) [combined inhibitors of CYP3A4, P-gp and, BCRP] with APX.https://jdc.jefferson.edu/petposters/1005/thumbnail.jp

Formulation of Sodium Alginate Nanospheres Containing Amphotericin B for the Treatment of Systemic Candidiasis

Purpose: The aim of this work was to formulate sodium alginate nanospheres of amphotericin B by controlled gellification method and to evaluate the role of the nanospheres as a “passive carrier” in targeted antifungal therapy. Methods: Sodium alginate nanospheres of amphotericin B were prepared by controlled gellification method, and the particle size analysis was carried out by scanning electron microscopy. The carrier capacity of sodium alginate was evaluated in terms of drug to polymer ratio. In vitro release study was carried out on all drug loaded nanospheres by the dialysis method. Release kinetics of drug from different drug loaded nanospheres was also determined. The in vivo antifungal efficacy of nanospheres bound drug vis-à-vis the free drug was evaluated in candidiasis- induced mice models. Results: Preparation of nanospheres through controlled gellification method yielded particles with a size range of 419.6 ± 0.28 nm. Studies on drug to polymer ratio showed a linear relationship between concentration of drug and drug loading capacity. In vitro release kinetic study revealed that the release of drug from the nanospheres followed Fickian diffusion. In vivo studies showed that the nanosphere-bound drug produced a higher antifungal efficacy than the free drug. Conclusion: The formulated sodium alginate nanospheres containing amphotericin B was found to have better antifungal activity when compared to the free drug and also yielded sustained in vitro release. Keywords: Nanospheres, sodium alginate, amphotericin B, controlled gellification method, in vitro & in vivo release > Tropical Journal of Pharmaceutical Research Vol. 6 (1) 2007: pp. 653-65

Development and in-vitro Evaluation of a Topical Drug Delivery System Containing Betamethazone Loaded Ethyl Cellulose Nanospheres

Purpose: Lipid nanospheres are used for the passive targeting of cosmetic agents to skin, thereby achieving major benefits such as reduction of total dose and avoidance of systemic absorption. The present study was carried out to exploit the feasibility of using polymeric nanospheres as an alternative and cheaper carrier for targeting corticosteroids to the skin. Methods: Nanospheres were prepared from ethyl cellulose by a modified method of desolvation and cross linking. The drug betamethazone was incorporated into nanospheres and the drug: polymer ratio was evaluated to determine the carrier capacity of the polymer. In-vitro release studies of drug-loaded nanospheres were carried out by the centrifugal ultrafiltration method. The kinetics of release was determined and fitted to an empirical equation. The release of drug from drug-loaded nanospheres dispersing in a conventional cream was evaluated. A comparative in-vitro diffusion study was carried out between a commercial brand of cream and the cream incorporating nanospheres. Results: Formulation of nanospheres of betamethazone by a modified method produced discrete particles. Studies on drug:polymer ratio showed a linear relationship between drug concentration and percentage of loading. The in-vitro release of drug-loaded nanospheres was found to be first order. The comparative in-vitro diffusion study between the commercial cream and the formulated cream showed a marked reduction in release rate from nanospheres-bound cream. Conclusion: Formulated topical cream containing nanospheres of betamethazone was found to be a potential dermal delivery system for sustaining the release of the drug. Keywords: Nanospheres, desolvation and cross-linking method, ethyl cellulose, betamethazone, in-vitro diffusion studies.> Tropical Journal of Pharmaceutical Research Vol. 4 (2) 2005: pp. 495-50

Awareness on antibiotic usage among undergraduate medical students in a teaching hospital, Guntur

Background: Antibiotics are the mainstay treatment of most of the infectious diseases. Inappropriate and irrational use of antimicrobial agents has led to increase in the development of antimicrobial resistance. Medical students are a part of health care system and they must be aware of increasing antibiotic resistance as they are the future prescribers. The objectives of the study were to assess the awareness on antibiotic usage and its resistance among medical students and to study the perception on antibiotic medication among medical students.Methods: This was a cross-sectional, semi-structured questionnaire-based study. Questionnaire consists of 4 parts- socio-demographic details, awareness on antibiotics and its resistance, knowledge on specific treatment of a disease, perception levels. Prior IEC approval was taken. The obtained data was statistically analyzed using Microsoft excel sheet.Results: Among 230 participants, majority of the students have awareness on general antibiotic usage and 97.8% were having knowledge about antibiotic resistance. The main source of information on antibiotic resistance is identified as classroom teaching (67.8%). 46.9% and 25.2% students correctly identified the drug of choice for treating enteric fever and community acquired pneumonia respectively.Conclusions: Degrees of awareness on antibiotics and its resistance is found to be good. Antibiotic usage pattern is not on par with knowledge. Knowledge on specific treatment of infectious disease is found to be less. So, antibiotic teaching should be integrated with clinical subjects

Post-harvest soil nutrient prediction in hybrid castor (Ricinus communis l.) Cropping sequence using a multivariate analysis technique

In the era of precision agriculture, the fertilizer prescription based on the soil fertility status is much required.  Analyzing the soil after each crop is necessary for fertilizer recommendation and developing an alternative technique to forecast the soil available nutrient value rather than analyzing the soil. Multiple linear regression (MLR) equation was developed using filed experiment data to predict the soil available nutrient in castor cropping sequence. The post-harvest soil available nutrient was considered as the dependent variable and the initially available soil nutrient values, fertilizer added, yield and nutrient uptake of castor as an independent variable. In general, the post-harvest soil nutrient model's prediction accuracy was notable and had a coefficient of determination of less than 0.90. By calculating the RMSE (root means square error), R2 value, the ratio performance to deviation (RPD) and, RE (relative error) the performance of the MLR model was confirmed.Using the validated model, post-harvest soil available nutrients were predicted and compared with laboratory tested soil available nutreints. It turned out that the established model is more precisely effective and equally precise. Fertilizer recommendation could be made to subsequent crop after hybrid castor using the predicted soil available nutrients

Haney's Ideas on Economic Value

History of Economic Thought deals with the origin and development of economic ideas, concepts, laws and theories. It is the process of searching, understanding, analyzing and interpreting the economic ideas. It is imperative to study the economic history to gain knowledge about economic theories. If one wants to understand the present phenomena clearly he has to know what happened in the past.This study deals with the ideas of Lewis Henry Haney about the very important basic economic concept i.e., “value”. It can be understood that starting from the Greek Philosopher like Aristotle so many economists carry out the analysis and interpretation of the idea of ‘value’. Among them Lewis Henry Haney, is one of the notably Economic Historian who indulged in analyzing the ‘value’ concept. That can be traced in his famous book titled ‘Value and Distribution’

Leveraging Structural and Semantic Measures for JSON Document Clustering

In recent years, the increased use of smart devices and digital business opportunities has generated massive heterogeneous JSON data daily, making efficient data storage and management more difficult. Existing research uses different similarity metrics and clusters the documents to support the above tasks effectively. However, extant approaches have focused on either structural or semantic similarity of schemas. As JSON documents are application-specific, differently annotated JSON schemas are not only structurally heterogeneous but also differ by the context of the JSON attributes. Therefore, there is a need to consider the structural, semantic, and contextual properties of JSON schemas to perform meaningful clustering of JSON documents. This work proposes an approach to cluster heterogeneous JSON documents using the similarity fusion method. The similarity fusion matrix is constructed using structural, semantic, and contextual measures of JSON schemas. The experimental results demonstrate that the proposed approach outperforms the existing approaches significantly.&nbsp

Haney's Ideas on Economic Value

History of Economic Thought deals with the origin and development of economic ideas, concepts, laws and theories. It is the process of searching, understanding, analyzing and interpreting the economic ideas. It is imperative to study the economic history to gain knowledge about economic theories. If one wants to understand the present phenomena clearly he has to know what happened in the past.This study deals with the ideas of Lewis Henry Haney about the very important basic economic concept i.e., “value”. It can be understood that starting from the Greek Philosopher like Aristotle so many economists carry out the analysis and interpretation of the idea of ‘value’. Among them Lewis Henry Haney, is one of the notably Economic Historian who indulged in analyzing the ‘value’ concept. That can be traced in his famous book titled ‘Value and Distribution’