Effect of embryo culture media on birthweight and length in singleton term infants after IVF-ICSI.

QUESTIONS UNDER STUDY: To investigate if two distinct, commercially available embryo culture media have a different effect on birthweight and length of singleton term infants conceived after IVF-ICSI. METHODS: University hospital based cohort study. Between 1 January 2000 and 31 December 2004, patients conceiving through IVF-ICSI at the University Hospital, Lausanne have been allocated to two distinct embryo culture media. Only term singleton pregnancies were analysed (n = 525). Data analysis was performed according to two commercially available culture media: Vitrolife (n = 352) versus Cook (n = 173). Analysis was performed through linear regression adjusted for confounders. Media were considered equivalent if the 95% confidence interval lay between -150 g/+150 g. RESULTS: Length, gestational age and distribution of birthweight percentiles did not differ between groups (for both genders). Analysis of the whole cohort, adjusted for a subset of confounders, resulted in a statistically not different mean birthweight between the two groups (Vitrolife +37 g vs Cook, 95%CI: -46 g to 119 g) suggesting equivalence. Adjustment for an enlarged number of confounders in a subsample of patients (n = 258) also revealed no relevant mean birthweight difference of +71 g (95%CI: -45 g to 187 g) in favour of Vitrolife; however, lacking power to prove equivalence. CONCLUSIONS: Our data suggest that significant differences in birthweight due to these two distinct, commercially available embryo culture media are unlikely

Abiraterone acetate in metastatic castration-resistant prostate cancer after chemotherapy. A retrospective “Real Life” analysis of activity and safety

Abiraterone acetate (AA) is a potent, selective androge (CYP17) biosynthesis inhibitor, which showed to improve overall survival (HR = 0.646) in mCRPC patients progressing after docetaxel. In this retrospective analysis we assessed the safety and efficacy of AA in patients affected with mCRPC progressing after chemotherapy, treated in the normal clinical practice, in several Italian Oncologic Units, after the approval of the drug from the Italian Drug Agency (AIFA)

A Wind Turbine Tower Design Based on the Use of Fibre-Reinforced Composites.

Abstract not availableJRC.G-Institute for the Protection and the Security of the Citizen (Ispra

Cognitive differentiation during childhood: A study on cognitive profiles of 5, 7, and 9-year-old children

No seio do debate sobre se a inteligência é mais bem definida por um fator geral ou por aptidões específicas, ganha relevância a hipótese da diferenciação cognitiva. Análises recentes enfatizam o interesse dessa questão para a investigação e alertam para a relevância das suas implicações na área educativa. Este estudo analisou a possibilidade de a diferenciação das aptidões cognitivas ocorrer já na infância e também o efeito moderador do Quociente de Inteligência na magnitude da relação entre as habilidades cognitivas. Aplicou-se uma bateria de provas que avaliam várias funções cognitivas a uma amostra de 231 crianças com 5, 7 e 9 anos, distribuídas por três grupos de desempenho cognitivo. Os resultados de uma análise de clusters hierárquica e de uma análise de variância apontam para a não diferenciação das funções cognitivas na infância. Contudo, uma análise mais cuidadosa aponta para alguma diferenciação suportada pela heterogeneidade dos perfis cognitivos junto dos alunos com Quociente de Inteligência elevado.Within the debate about whether intelligence is best defined by a general factor or specific skills, the hypothesis of cognitive differentiation gains relevance. Recent analyses have emphasized the importance of this issue in the investigation of cognitive skills and have highlighted its implications in education. This study examined the possibility that the differentiation of cognitive abilities may occur during childhood and investigated the moderating effect of Intelligence Quotient on the magnitude of the relationship between cognitive abilities. A battery of tests for assessing cognitive function was administered to 231 children aged 5, 7, and 9 years old, who were divided into three cognitive performance groups. The results of hierarchical cluster analysis and variance analysis indicate the lack of differentiation of cognitive functions during childhood. However, a more careful analysis suggests some differentiation supported by the heterogeneity of cognitive profiles among students with high Intelligence Quotient.FCT -Fundação para a Ciência e a Tecnologia(SFRH/BD/84153/2012

Professional excellence: the necessary convergence of psychological variables

O estudo da excelência humana assume essencialmente dois enfoques, um deles acentuando as variáveis psicológicas dos indivíduos e outro enfatizando as aquisições decorrentes da prática ou treino deliberado. Neste artigo procurou-se integrar tais estudos, propondo que o surgimento e a manutenção da excelência pressupõem uma constelação de variáveis psicológicas que vão para além da alta capacidade intelectual. Mais concretamente, descreveu-se um conjunto de variáveis cognitivas, motivacionais e de personalidade, assumidas como relevantes na excelência profissional em diferentes áreas de desempenho e de conhecimento. No seio das variáveis cognitivas e, fazendo uma ponte com as variáveis de personalidade, destaca-se o papel da criatividade para a excelência, reconhecendo a sua particular relevância em algumas áreas de realização profissional.The study of human excellence can be described based on two main approaches focusing either on individuals' psychological variables or on acquisitions by training or deliberate practice. The purpose of this study is to integrate these models based on the assumption that the emergence and maintenance of excellence requires a constellation of fundamental psychological variables that transcend intellectual capacity. More specifically, a set of cognitive, motivational, and personality variables that are considered important for professional excellence in different levels of performance and areas of knowledge were described. Among the cognitive variables and their association with personality variables, it is worth mentioning the significant role of creativity in the pursuit of excellence, recognizing its relevance to specific areas of professional performance.(undefined

Slower is not always better: Response-time evidence clarifies the limited role of miserly information processing in the Cognitive Reflection Test

We report a study examining the role of `cognitive miserliness' as a determinant of poor performance on the standard three-item Cognitive Reflection Test (CRT). The cognitive miserliness hypothesis proposes that people often respond incorrectly on CRT items because of an unwillingness to go beyond default, heuristic processing and invest time and effort in analytic, reflective processing. Our analysis (N = 391) focused on people's response times to CRT items to determine whether predicted associations are evident between miserly thinking and the generation of incorrect, intuitive answers. Evidence indicated only a weak correlation between CRT response times and accuracy. Item-level analyses also failed to demonstrate predicted response time differences between correct analytic and incorrect intuitive answers for two of the three CRT items. We question whether participants who give incorrect intuitive answers on the CRT can legitimately be termed cognitive misers and whether the three CRT items measure the same general construct

The illusion of replacement in research into the development of thinking biases: the case of the conjunction fallacy

The conjunction fallacy is a violation of a very basic rule of probability. Interestingly, although committing the fallacy seems irrational, adults are no less susceptible to the fallacy than young children. In Experiment 1, by employing tasks where the conjunctive response option involved two non-representative items, we found a large reduction in fallacy rates as compared to traditional conjunction fallacy problems. Nevertheless, fallacy rates remained relatively high in both adolescents and adults, although adults showed more consistency in their normative responses. In Experiment 2, we demonstrated that children’s relatively good performance on the task was not the consequence of their missing knowledge of social stereotypes. Additionally, children were more strongly affected by explicitly presented frequency information than adults. Indeed, adults only took frequency information into account when frequencies were made relevant by a training in probabilistic reasoning. Overall, the results suggest that whereas the potential for normative reasoning increases with development, this potential is often overshadowed by a pervasive tendency in adolescence and adulthood to rely on contextual information, knowledge, and beliefs, even when conflicting information is available. By contrast, children are more strongly influenced by explicitly presented information than relevant knowledge cued by the tasks.This research, and the writing of this paper, was partially supported by a UK Economic and Social Research Council post-doctoral fellowship [PTA-026-27-2989] to KM

The Wild Boar as an Ecosystem Service: Moving Steps Towards Biodiversity Engineering

The aim of the study is to address the problems related to the conflict between natural resources, such as wild boars, with agricultural and livestock activities producing ecosystem services or disservices. The authors propose a process inversion, even if considered unprofitable: capturing subadult wild boars (6-12 months of age) and then slaughtering them. Thirty female wild boars were divided into three groups (G1 = 6-8 months juveniles; G2 = 9-12 months subadults; G3 = >12 months adults) and then slaughtered in an authorized factory. Live and dressed weight were different (P≤0.01) among the groups. The weights of the sides and the cuts of meat, fat and pluck were not different between G2 and G3, while they differed from G1. Intestinal tract weight showed differences (P≤0.01) between G1 versus older age groups which, however, differed less markedly between them (P≤0.05). The ratios (warm yield, side/dead weight, cut of meat/side, and cut of fat/side) did not show differences between groups. The results obtained indicate that young animals' warm yields do not fall below 80%, and that young and subadult animals are able to guarantee the containment of wild populations but also a slaughtering controlled by official veterinarians as well as food safety and hygienic-sanitary control