Meadow Park Community Gardens Improvements

The San Luis Obispo Community Gardens offer space for residents to grow food at a low-cost yearly lease. Among the five Community Gardens in the city, there are over 100 plots available to purchase. These plots can vary from in-ground garden beds, off-ground raised garden beds, and ADA accessible garden beds. The goal with this project is to provide the Community Gardens with infrastructure to allow for a better garden experience and to increase the volume at which San Luis Obispo residents can utilize the gardens. Through communication with the San Luis Obispo Community Gardens, we were able to determine the most necessary improvements for the community gardens: Six Wood ADA Accessible Raised Garden Beds and one Wood 3-Bin Compost System. The garden beds are 2’x4’ and 3’ tall. The compost bin is 3’x9’ and 3’ tall and separated into three 3’x3’x3’ compartments. These garden beds and compost bins will be placed at the Meadow Park Community Garden. This project was lead by the author and assisted by members of the Cal Poly Construction Management department. This project was funded by JB Pacific

The Democratic Biopolitics of PrEP

PrEP (Pre-Exposure Prophylaxis) is a relatively new drug-based HIV prevention technique and an important means to lower the HIV risk of gay men who are especially vulnerable to HIV. From the perspective of biopolitics, PrEP inscribes itself in a larger trend of medicalization and the rise of pharmapower. This article reconstructs and evaluates contemporary literature on biopolitical theory as it applies to PrEP, by bringing it in a dialogue with a mapping of the political debate on PrEP. As PrEP changes sexual norms and subjectification, for example condom use and its meaning for gay subjectivity, it is highly contested. The article shows that the debate on PrEP can be best described with the concepts ‘sexual-somatic ethics’ and ‘democratic biopolitics’, which I develop based on the biopolitical approach of Nikolas Rose and Paul Rabinow. In contrast, interpretations of PrEP which are following governmentality studies or Italian Theory amount to either farfetched or trivial positions on PrEP, when seen in light of the political debate. Furthermore, the article is a contribution to the scholarship on gay subjectivity, highlighting how homophobia and homonormativity haunts gay sex even in liberal environments, and how PrEP can serve as an entry point for the destigmatization of gay sexuality and transformation of gay subjectivity. ‘Biopolitical democratization’ entails making explicit how medical technology and health care relates to sexual subjectification and ethics, to strengthen the voice of (potential) PrEP users in health politics, and to renegotiate the profit and power of Big Pharma

Educación cimarrona

La presente obra consta de tres partes bien definidas: la primera expone el resultado de los talleres y el trabajo de las coordinadoras de los Centros de Educación Cimarrona de los siguientes barrios de Sucumbíos: El Cisne, Amazonas, San Valentín y la parroquia Pacayacu, y recupera historias de viada de hombres y mujeres así como la tradición oral presente en su memoria colectiva y recuperada por el grupo de trabajo. La segunda parte consta de las reflexiones teóricas sobre el cimarronaje y los fundamentos conceptuales que inspiran los Centros de Educación Cimarrona. La tercera y última sección ofrece, en primer lugar, el relato reflexivo de los talleres de grafoplástica identitaria y, luego, una guía para niños investigadores al servicio de la revitalización de la cultura, las identidades y las memorias vivas de los pueblos cimarrone

Stroke in a pregnant female with a PFO in the absence of a clot.

Background: Patent Foramen Ovale (PFO) is a condition affecting about 25% of all adults. While the incidence of PFOs in pregnant women is unknown, there is an increased risk for stroke owing to major changes in hemocoagulative, hormonal, and cardiovascular parameters. Despite this, the incidence of a stroke is rare in pregnant women with a PFO. Furthermore, hemorrhagic strokes are far more common during pregnancy than ischemic strokes, as is the case here. In literature 80% of venous thromboembolisms in pregnancy are found to be associated with a DVT. In the case presented, there was no associated DVT and further hematological investigations revealed no evidence of a hypercoagulable disorder. Case Presentation: A 28-year-old female G3P2A1, past medical history of migraines with aura presented to the emergency room with altered mental status, diplopia, and dizziness 12 days after undergoing a cesarean-section. While in the ER she lost consciousness for about 2 hours. Physical examination was difficult to perform due to mental status but there were no significant focal deficits on regaining consciousness. An MRI of the brain showed an acute right thalamic infarct. However, bilateral doppler of the lower extremities was negative for thrombosis. She was started on antiplatelet therapy and her symptoms resolved in 24 hours. A transthoracic echocardiogram with bubble study was significant for a possible PFO vs ASD and a PFO was confirmed on transesophageal echo. She was then discharged and hypercoagulation workup including extensive testing for antibodies, Protein C/S, Prothrombin gene mutations, Factor V Leiden were all negative. She then had surgical closure of the PFO and has been asymptomatic since. Conclusions: Although pregnancy is a hypercoagulable state, incidence of strokes and coronary artery diseases need to be investigated for rarer abnormalities like PFO

Rejuvenation of metallic glasses by non-affine thermal strain.

When a spatially uniform temperature change is imposed on a solid with more than one phase, or on a polycrystal of a single, non-cubic phase (showing anisotropic expansion-contraction), the resulting thermal strain is inhomogeneous (non-affine). Thermal cycling induces internal stresses, leading to structural and property changes that are usually deleterious. Glasses are the solids that form on cooling a liquid if crystallization is avoided--they might be considered the ultimate, uniform solids, without the microstructural features and defects associated with polycrystals. Here we explore the effects of cryogenic thermal cycling on glasses, specifically metallic glasses. We show that, contrary to the null effect expected from uniformity, thermal cycling induces rejuvenation, reaching less relaxed states of higher energy. We interpret these findings in the context that the dynamics in liquids become heterogeneous on cooling towards the glass transition, and that there may be consequent heterogeneities in the resulting glasses. For example, the vibrational dynamics of glassy silica at long wavelengths are those of an elastic continuum, but at wavelengths less than approximately three nanometres the vibrational dynamics are similar to those of a polycrystal with anisotropic grains. Thermal cycling of metallic glasses is easily applied, and gives improvements in compressive plasticity. The fact that such effects can be achieved is attributed to intrinsic non-uniformity of the glass structure, giving a non-uniform coefficient of thermal expansion. While metallic glasses may be particularly suitable for thermal cycling, the non-affine nature of strains in glasses in general deserves further study, whether they are induced by applied stresses or by temperature change.This research was supported by the World Premier International Research Center Initiative (WPI), MEXT, Japan, by NSF China and MOST 973 China, and by the Engineering and the Engineering and Physical Sciences Research Council, UK (Materials World Network project). Y.H.S. acknowledges support from a China Scholarship Council (CSC) scholarship.This is the author accepted manuscript. The final version is available from Nature Publishing Group via http://dx.doi.org/10.1038/nature1467

Intermediation for technology diffusion and user innovation in a developing rural economy:a social learning perspective

Technology intermediaries are seen as potent vehicles for addressing perennial problems in transferring technology from university to industry in developed and developing countries. This paper examines what constitutes effective user-end intermediation in a low-technology, developing economy context, which is an under-researched topic. The social learning in technological innovation framework is extended using situated learning theory in a longitudinal instrumental case study of an exemplar technology intermediation programme. The paper documents the role that academic-related research and advisory centres can play as intermediaries in brokering, facilitating and configuring technology, against the backdrop of a group of small-scale pisciculture businesses in a rural area of Colombia. In doing so, it demonstrates how technology intermediation activities can be optimized in the domestication and innofusion of technology amongst end-users. The design components featured in this instrumental case of intermediation can inform policy making and practice relating to technology transfer from university to rural industry. Future research on this subject should consider the intermediation components put forward, as well as the impact of such interventions, in different countries and industrial sectors. Such research would allow for theoretical replication and help improve technology domestication and innofusion in different contexts, especially in less-developed countries

Parametric and sensitivity analysis for a proposed filtered tailings storage facility in challenging topography

Parametric and sensitivity analyses were performed for a proposed filtered tail- ings storage facility in challenging topography from the Southern Peru region. The purpose was to identify elements which are likely to dictate performance and stability, and to understand the risk profile for the facility. The analyses were performed varying: foundation material physical and hydraulic properties, tailings physical and hydraulic properties, foundation configuration, seismicity, and staged construction. The physical properties of the foundation material were varied by changing the Mohr-Coulomb strength parameters c’ and φ’, whereas the hydraulic properties were varied by moving the groundwater table upwards or saturating a larger amount of the foundation material. A similar approach was adopted in order to vary the physical and hydraulic properties of the tailings. The foundation configuration was varied by hypothetically moving the starter buttress closer to the edge of steep slopes further downhill from the facility. Staged construction stability analyses were simulated by analyzing filtered tailings fill configurations, which followed the overall design slope but varied in height. All analyses presented herein were conducted for the most critical failure mode for each scenario. The results from these parametric analyses showed that the design of the facility was highly sensitive to tailings potential saturation. In the simulation scenarios, saturation of the tailings caused instability in both static and seismic conditions. This sensitivity to moisture conditions highlighted the importance of properly defining the unsaturated filtered tailings parameters and simulating water infiltration processes through the vadose zone.Fil: Preciado, H. F. AMEC S.A; Perú.Fil: Ale, J. AMEC S.A; Perú.Fil: Byler, B. AMEC Englewood; USA.Fil: Perez, F. AMEC S.A; Perú.Fil: Mejía, V. AMEC S.A; Perú.Fil: McIver, D. Minera IRL SA; Perú.Otras Ingeniería Civi

Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation : Data From ROCKET AF

M. Kaste on työryhmän ROCKET AF Steering Comm jäsen.Background-Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. Methods and Results-In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) study, patients with nonvalvular atrial fibrillation were randomized to rivaroxaban or dose-adjusted warfarin. Cox proportional hazards regression with backward elimination identified factors at randomization that were independently associated with all-cause mortality in the 14 171 participants in the intention-to-treat population. The median age was 73 years, and the mean CHADS(2) score was 3.5. Over 1.9 years of median follow-up, 1214 (8.6%) patients died. Kaplan-Meier mortality rates were 4.2% at 1 year and 8.9% at 2 years. The majority of classified deaths (1081) were cardiovascular (72%), whereas only 6% were nonhemorrhagic stroke or systemic embolism. No significant difference in all-cause mortality was observed between the rivaroxaban and warfarin arms (P=0.15). Heart failure (hazard ratio 1.51, 95% CI 1.33-1.70, P= 75 years (hazard ratio 1.69, 95% CI 1.51-1.90, P Conclusions-In a large population of patients anticoagulated for nonvalvular atrial fibrillation, approximate to 7 in 10 deaths were cardiovascular, whereasPeer reviewe

CompareML: A Novel Approach to Supporting Preliminary Data Analysis Decision Making.

There are a large number of machine learning algorithms as well as a wide range of libraries and services that allow one to create predictive models. With machine learning and artificial intelligence playing a major role in dealing with engineering problems, practising engineers often come to the machine learning field so overwhelmed with the multitude of possibilities that they find themselves needing to address difficulties before actually starting on carrying out any work. Datasets have intrinsic properties that make it hard to select the algorithm that is best suited to some specific objective, and the ever-increasing number of providers together make this selection even harder. These were the reasons underlying the design of CompareML, an approach to supporting the evaluation and comparison of machine learning libraries and services without deep machine learning knowledge. CompareML makes it easy to compare the performance of different models by using well-known classification and regression algorithms already made available by some of the most widely used providers. It facilitates the practical application of methods and techniques of artificial intelligence that let a practising engineer decide whether they might be used to resolve hitherto intractable problems. Thus, researchers and engineering practitioners can uncover the potential of their datasets for the inference of new knowledge by selecting the most appropriate machine learning algorithm and determining the provider best suited to their data