Rover Exploration of Acidalia Mensa and Acidalia Planitia: Probing Mud Volcanoes to Sample Buried Sediments and Search for Ancient and Extant Life

Here we develop a plan to explore mud volcanoes near Acidalia Mensa with an MSL-class rover and propose a traverse based on geologic observations

Regional Mapping and Spectral Analysis of Mounds in Acidalia Planitia, Mars

Acidalia Planitia is a approx.3000 km diameter planum located in the northern plains of Mars. It is believed to be a sedimentary basin containing an accumulation of sediments brought by Hesperian outflow channels that drained the Highlands. A large number of high-albedo mounds have been identified across this basin [1-2] and understanding the process that formed them should help us understand the history of this region. Farrand et al. [2] showed that the mounds are dark in THEMIS (Thermal Emission Imaging System) nighttime IR (infrared) image data. This implies that the mounds have a lower thermal inertia than the surrounding plains (Fig. 1), suggesting that the material of the mounds is fine-grained or unconsolidated. Farrand et al. [2] also reviewed potential analogs for the mounds and concluded that a combination of mud volcanoes with evaporites around geysers or springs is most consistent with all the data. We have built on this work by creating regional maps of the features and analyzing CRISM (Compact Reconnaissance Imaging Spectrometer for Mars) data to see if there are mineralogical differences between the mounds and surrounding plains

Candidate Landing Site for the Mars Science Laboratory: Vernal Crater, S.W. ARabia Terra

In the fall of 2009, the Mars Science Laboratory (MSL) will be launched to Mars. The purpose of this mission is to assess biologic potential and geology and to investigate planetary processes of relevance to past habitability. MSL will be able to provide visual, chemical, radiation, and environmental data with its suite of instruments [1]. In order to be selected for the MSL landing site, certain engineering requirements must be met [1] and the area should contain geologic features suggestive of past habitability, so that the overriding science goal of the mission will be attained. There are a total of 33 proposed landing sites as of the first MSL Landing Site Workshop held in Pasadena, CA from May 31st to June 2nd, 2006 [1]. There will be an opportunity to gather high resolution visual and hyperspectral data on all proposed landing sites from the now-orbiting Mars Reconnaissance Orbiter (MRO) which entered martian orbit and began its main science phase in November of 2006 [2]. The data being gathered are from: the high resolution imaging science experiment (HiRISE), the context (CTX) camera and the compact reconnaissance imaging spectrometer (CRISM) onboard the spacecraft. The footprints of these instruments are centered on a single point, and each proposer must submit these coordinates, along with the coordinates of the proposed landing ellipse. Data from these instruments, along with new MOC images and THEMIS mosaics, will be used to enhance our understanding of the geologic and engineering parameters of each site

Principles for developing benchmark criteria for staff training in responsible gambling

One approach to minimizing the negative consequences of excessive gambling is staff training to reduce the rate of the development of new cases of harm or disorder within their customers. The primary goal of the present study was to assess suitable benchmark criteria for the training of gambling employees at casinos and lottery retailers. The study utilised the Delphi Method, a survey with one qualitative and two quantitative phases. A total of 21 invited international experts in the responsible gambling field participated in all three phases. A total of 75 performance indicators were outlined and assigned to six categories: (1) criteria of content, (2) modelling, (3) qualification of trainer, (4) framework conditions, (5) sustainability and (6) statistical indicators. Nine of the 75 indicators were rated as very important by 90 % or more of the experts. Unanimous support for importance was given to indicators such as (1) comprehensibility and (2) concrete action-guidance for handling with problem gamblers, Additionally, the study examined the implementation of benchmarking, when it should be conducted, and who should be responsible. Results indicated that benchmarking should be conducted every 1–2 years regularly and that one institution should be clearly defined and primarily responsible for benchmarking. The results of the present study provide the basis for developing a benchmarking for staff training in responsible gambling

The vascular bone marrow niche influences outcome in chronic myeloid leukemia via the E-selectin - SCL/TAL1-CD44 axis.

The endosteal bone marrow niche and vascular endothelial cells provide sanctuaries for leukemic cells. In murine chronic myeloid leukemia (CML) CD44 on leukemia cells and E-selectin on bone marrow endothelium are essential mediators for the engraftment of leukemic stem cells. We hypothesized that non-adhesion of CML-initiating cells to E-selectin on the bone marrow endothelium may lead to superior eradication of leukemic stem cells in CML after treatment with imatinib than imatinib alone. Indeed, here we show that treatment with the E-selectin inhibitor GMI-1271 in combination with imatinib prolongs survival of mice with CML via decreased contact time of leukemia cells with bone marrow endothelium. Non-adhesion of BCR-ABL1(+) cells leads to an increase of cell cycle progression and an increase of expression of the hematopoietic transcription factor and proto-oncogene Scl/Tal1 in leukemia-initiating cells. We implicate SCL/TAL1 as an indirect phosphorylation target of BCR-ABL1 and as a negative transcriptional regulator of CD44 expression. We show that increased SCL/TAL1 expression is associated with improved outcome in human CML. These data demonstrate the BCR-ABL1-specific, cell-intrinsic pathways leading to altered interactions with the vascular niche via the modulation of adhesion molecules - which could be exploited therapeutically in the future

Virtual Electrode Design for Lithium-Ion Battery Cathodes

Microstructural characteristics of lithium‐ion battery cathodes determine their performance. Thus, modern simulation tools are increasingly important for the custom design of multiphase cathodes. This work presents a new method for generating virtual, yet realistic cathode microstructures. A precondition is a 3D template of a commercial cathode, reconstructed via focused ion beam/scanning electron microscopy (FIB/SEM) tomography and appropriate algorithms. The characteristically shaped micrometer‐sized active material (AM) particles and agglomerates of nano‐sized carbon‐binder (CB) particles are individually extracted from the voxel‐based templates. Thereby, a library of roughly 1100 AM particles and 20 CB agglomerates is created. Next, a virtual cathode microstructure is predefined, and representative sets of AM particles and CB agglomerates are built. The following re‐assembly of AM particles within a predefined volume box works using dropping and rolling algorithms. Thereby, one can generate cathodes with specified characteristics, such as the volume fraction of AM, CB and pore space, particle‐size distributions, and gradients thereof. Naturally, such a virtual twin is a promising starting point for physics‐based electrochemical performance models. The workflow from the commercial cathode microstructure through to a full virtual twin will be explained and assessed for a blend cathode made of the two AMs, LiNiCoAlO$_{2}$ (NCA) and LiCoO$_{2}$ (LCO)

Layered Sediments, Rampart Craters, and Potential Fluvio-Lacustrine Activity in S.W. Arabia Terra, Mars: Support for a History of Aqueous Conditions

Arabia Terra is a unique area on Mars in that it is the only major, equatorial region characterized by high abundances of near-surface water (as measured by gamma ray and neutron spectroscopy). Vernal Crater is a 55 km-diameter structure in southwest Arabia Terra, centered at 6 N, 355.5 E. The crater includes layered sediments, potential remnants of fluvio-lacustrine activity, and indications of aeolian processes. Regional considerations, along with new THEMIS and MOC data, are being assessed to gain insight into the significance of the geomorphic units within Vernal Crater and the geologic history of SW Arabia Terra

Diversification in the Archean Biosphere: Insight from NanoSIMS of Microstructures in the Farrel Quartzite of Australia

The nature of early life on Earth is difficult to assess because potential Early Archean biosignatures are commonly poorly preserved. Interpretations of such materials have been contested, and abiotic or epigenetic derivations have been proposed (summarized in [1]). Yet, an understanding of Archean life is of astrobiological importance, as knowledge of early evolutionary processes on Earth could provide insight to development of life on other planets. A recently-discovered assemblage of organic microstructures in approx.3 Ga charts of the Farrel Quartzite (FQ) of Australia [2-4] includes unusual spindle-like forms and a variety of spheroids. If biogenicity and syngeneity of these forms could be substantiated, the FQ assemblage would provide a new view of Archean life. Our work uses NanoSIMS to further assess the biogenicity and syngeneity of FQ microstructures. In prior NanoSIMS studies [5-6], we gained an understanding of nano-scale elemental distributions in undisputed microfossils from the Neoproterozoic Bitter Springs Formation of Australia. Those results provide a new tool with which to evaluate poorly preserved materials that we might find in Archean sediments and possibly in extraterrestrial materials. We have applied this tool to the FQ forms

Toward Lower Organic Environments in Astromaterial Sample Curation for Diverse Collections

Great interest was taken during the frenzied pace of the Apollo lunar sample return to achieve and monitor organic cleanliness. Yet, the first mission resulted in higher organic contamination to samples than desired. But improvements were accomplished by Apollo 12 [1]. Quarantine complicated the goal of achieving organic cleanliness by requiring negative pressure glovebox containment environments, proximity of animal, plant and microbial organic sources, and use of organic sterilants in protocols. A special low organic laboratory was set up at University of California Berkeley (UCB) to cleanly subdivide a subset of samples [2, 3, 4]. Nevertheless, the basic approach of handling rocks and regolith inside of a positive pressure stainless steel glovebox and restrict-ing the tool and container materials allowed in the gloveboxes was established by the last Apollo sample re-turn. In the last 40 years, the collections have grown to encompass Antarctic meteorites, Cosmic Dust, Genesis solar wind, Stardust comet grains and Hayabusa asteroid grains. Each of these collections have unique curation requirements for organic contamination monitor-ing and control. Here is described some changes allowed by improved technology or driven by changes in environmental regulations and economy, concluding with comments on organic witness wafers. Future sample return missions (OSIRIS-Rex; Mars; comets) will require extremely low levels of organic contamination in spacecraft collection and thus similarly low levels in curation. JSC Curation is undertaking a program to document organic baseline levels in current operations and devise ways to reduce those levels