156 research outputs found
Communication design for health. Territorial and digital networks
In the wake of the Covid-19 pandemic emergency, there has been renewed interest in issues related
to health, prevention and community well-being. Health communication and the promotion of disease prevention now require a theoretical and design approach that first and foremost requires the
identification of appropriate tools to enhance âintersectoralityâ, âcollaborationâ and âoutreachâ among
the different areas of expertise of the well-being and healthcare actors involved in the territory. The
aim is to strengthen the process of community âempowermentâ. This study investigates the communicative strategies suitable for enhancing the physical, virtual and digital relationships among the active presences in the territory, choosing those capable of mediating needs, promoting well-being and
building a dialogue between citizens and health facilities, thus finally creating a âterritorial health
networkâ
Antiretroviral Therapy outcomes among adolescents and youth in rural Zimbabwe
Around 2 million adolescents and 3 million youth are estimated to be living with HIV worldwide. Antiretroviral outcomes for this group appear to be worse compared to adults. We report antiretroviral therapy outcomes from a rural setting in Zimbabwe among patients aged 10-30 years who were initiated on ART between 2005 and 2008. The cohort was stratified into four age groups: 10-15 (young adolescents) 15.1-19 years (adolescents), 19.1-24 years (young adults) and 24.1-29.9 years (older adults). Survival analysis was used to estimate rates of deaths and loss to follow-up stratified by age group. Endpoints were time from ART initiation to death or loss to follow-up. Follow-up of patients on continuous therapy was censored at date of transfer, or study end (31 December 2008). Sex-adjusted Cox proportional hazards models were used to estimate hazard ratios for different age groups. 898 patients were included in the analysis; median duration on ART was 468 days. The risk of death were highest in adults compared to young adolescents (aHR 2.25, 95%CI 1.17-4.35). Young adults and adolescents had a 2-3 times higher risk of loss to follow-up compared to young adolescents. When estimating the risk of attrition combining loss to follow-up and death, young adults had the highest risk (aHR 2.70, 95%CI 1.62-4.52). This study highlights the need for adapted adherence support and service delivery models for both adolescents and young adults
Data-Driven Key Performance Indicators and Datasets for Building Energy Flexibility: A Review and Perspectives
Energy flexibility, through short-term demand-side management (DSM) and
energy storage technologies, is now seen as a major key to balancing the
fluctuating supply in different energy grids with the energy demand of
buildings. This is especially important when considering the intermittent
nature of ever-growing renewable energy production, as well as the increasing
dynamics of electricity demand in buildings. This paper provides a holistic
review of (1) data-driven energy flexibility key performance indicators (KPIs)
for buildings in the operational phase and (2) open datasets that can be used
for testing energy flexibility KPIs. The review identifies a total of 81
data-driven KPIs from 91 recent publications. These KPIs were categorized and
analyzed according to their type, complexity, scope, key stakeholders, data
requirement, baseline requirement, resolution, and popularity. Moreover, 330
building datasets were collected and evaluated. Of those, 16 were deemed
adequate to feature building performing demand response or building-to-grid
(B2G) services. The DSM strategy, building scope, grid type, control strategy,
needed data features, and usability of these selected 16 datasets were
analyzed. This review reveals future opportunities to address limitations in
the existing literature: (1) developing new data-driven methodologies to
specifically evaluate different energy flexibility strategies and B2G services
of existing buildings; (2) developing baseline-free KPIs that could be
calculated from easily accessible building sensors and meter data; (3) devoting
non-engineering efforts to promote building energy flexibility, such as
designing utility programs, standardizing energy flexibility quantification and
verification processes; and (4) curating datasets with proper description for
energy flexibility assessments.Comment: 30 pages, 14 figures, 4 table
âA good little tool to get to know yourself a bit betterâ: a qualitative study on usersâ experiences of app-supported menstrual tracking in Europe
Background: Menstrual apps facilitate observation and analysis of menstrual cycles and associated factors through
the collection and interpretation of data entered by users. As a subgroup of health-related apps, menstrual apps
form part of one of the most dynamic and rapidly growing developments in biomedicine and health care.
However, despite their popularity, qualitative research on how people engaging in period-tracking use and
experience these apps remains scarce. Results: An inductive content analysis was performed and eight characteristics of app-supported menstrual
tracking were identified: 1) tracking menstrual cycle dates and regularities, 2) preparing for upcoming periods, 3)
getting to know menstrual cycles and bodies, 4) verifying menstrual experiences and sensations, 5) informing
healthcare professionals, 6) tracking health, 7) contraception and seeking pregnancy, and 8) changes in tracking.
Our study finds that period-tracking via apps has the potential to be an empowering practice as it helps users to be
more aware of their menstrual cycles and health and to gain new knowledge. However, we also show that
menstrual tracking can have negative consequences as it leads to distress in some cases, to privacy issues, and the
work it requires can result in cessation. Finally, we present practical implications for healthcare providers and app
developers.
Conclusions: This qualitative study gives insight into usersâ practices and experiences of app-supported menstrual
tracking. The results provide information for researchers, health care providers and app designers about the
implications of app-supported period-tracking and describe opportunities for patient-doctor interactions as well as
for further development of menstrual apps.This research has received funding from the European Unionâs Horizon 2020
research and innovation program under the Marie SkĆodowska-Curie grant
agreement No 675378
Not Just a Pathogen? : Description of a Plant-Beneficial Pseudomonas syringae Strain
Plants develop in a microbe-rich environment and must interact with a plethora of microorganisms, both pathogenic and beneficial. Indeed, such is the case of Pseudomonas, and its model organisms P. fluorescens and P. syringae, a bacterial genus that has received particular attention because of its beneficial effect on plants and its pathogenic strains. The present study aims to compare plant-beneficial and pathogenic strains belonging to the P. syringae species to get new insights into the distinction between the two types of plant-microbe interactions. In assays carried out under greenhouse conditions, P. syringae pv. syringae strain 260-02 was shown to promote plant-growth and to exert biocontrol of P. syringae pv. tomato strain DC3000, against the Botrytis cinerea fungus and the Cymbidium Ringspot Virus. This P. syringae strain also had a distinct volatile emission profile, as well as a different plant-colonization pattern, visualized by confocal microscopy and gfp labeled strains, compared to strain DC3000. Despite the different behavior, the P. syringae strain 260-02 showed great similarity to pathogenic strains at a genomic level. However, genome analyses highlighted a few differences that form the basis for the following hypotheses regarding strain 260-02. P. syringae strain 260-02: (i) possesses nonfunctional virulence genes, like the mangotoxin-producing operon Mbo; (ii) has different regulation pathways, suggested by the difference in the autoinducer system and the lack of a virulence activator gene; (iii) has genes encoding DNA methylases different from those found in other P. syringae strains, suggested by the presence of horizontal-gene-transfer-obtained methylases that could affect gene expression
Impact of chronic liver disease upon admission on COVID-19 in-hospital mortality: Findings from COVOCA study
Background Italy has been the first Western country to be heavily affected by the spread of SARS-COV-2 infection and among the pioneers of the clinical management of pandemic. To improve the outcome, identification of patients at the highest risk seems mandatory. Objectives Aim of this study is to identify comorbidities and clinical conditions upon admission associated with in-hospital mortality in several COVID Centers in Campania Region (Italy). Methods COVOCA is a multicentre retrospective observational cohort study, which involved 18 COVID Centers throughout Campania Region, Italy. Data were collected from patients who completed their hospitalization between March-June 2020. The endpoint was in-hospital mortality, assessed either from data at discharge or death certificate, whilst all exposure variables were collected at hospital admission. Results Among 618 COVID-19 hospitalized patients included in the study, 143 in-hospital mortality events were recorded, with a cumulative incidence of about 23%. At multivariable logistic analysis, male sex (OR 2.63, 95%CI 1.42â4.90; p = 0.001), Chronic Liver Disease (OR 5.88, 95%CI 2.39â14.46; p<0.001) and malignancies (OR 2.62, 95%CI 1.21â5.68; p = 0.015) disclosed an independent association with a poor prognosis, Glasgow Coma Scale (GCS) and Respiratory Severity Scale allowed to identify at higher mortality risk. Sensitivity analysis further enhanced these findings. Conclusion Mortality of patients hospitalized for COVID-19 appears strongly affected by both clinical conditions on admission and comorbidities. Originally, we observed a very poor outcome in subjects with a chronic liver disease, alongside with an increase of hepatic damage
Early downregulation of hsa-miR-144-3p in serum from drug-naĂŻve Parkinsonâs disease patients
open101siThis work was supported by the Horizon 2020 Framework Programme (Grant number 634821, PROPAG-AGING).Advanced age represents one of the major risk factors for Parkinsonâs Disease. Recent biomedical studies posit a role for microRNAs, also known to be remodelled during ageing. However, the relationship between microRNA remodelling and ageing in Parkinsonâs Disease, has not been fully elucidated. Therefore, the aim of the present study is to unravel the relevance of microRNAs as biomarkers of Parkinsonâs Disease within the ageing framework. We employed Next Generation Sequencing to profile serum microRNAs from samples informative for Parkinsonâs Disease (recently diagnosed, drug-naĂŻve) and healthy ageing (centenarians) plus healthy controls, age-matched with Parkinsonâs Disease patients. Potential microRNA candidates markers, emerging from the combination of differential expression and network analyses, were further validated in an independent cohort including both drug-naĂŻve and advanced Parkinsonâs Disease patients, and healthy siblings of Parkinsonâs Disease patients at higher genetic risk for developing the disease. While we did not find evidences of microRNAs co-regulated in Parkinsonâs Disease and ageing, we report that hsa-miR-144-3p is consistently down-regulated in early Parkinsonâs Disease patients. Moreover, interestingly, functional analysis revealed that hsa-miR-144-3p is involved in the regulation of coagulation, a process known to be altered in Parkinsonâs Disease. Our results consistently show the down-regulation of hsa-mir144-3p in early Parkinsonâs Disease, robustly confirmed across a variety of analytical and experimental analyses. These promising results ask for further research to unveil the functional details of the involvement of hsa-mir144-3p in Parkinsonâs Disease.openZago E.; Dal Molin A.; Dimitri G.M.; Xumerle L.; Pirazzini C.; Bacalini M.G.; Maturo M.G.; Azevedo T.; Spasov S.; Gomez-Garre P.; Perinan M.T.; Jesus S.; Baldelli L.; Sambati L.; Calandra Buonaura G.; Garagnani P.; Provini F.; Cortelli P.; Mir P.; Trenkwalder C.; Mollenhauer B.; Franceschi C.; Lio P.; Nardini C.; Adarmes-Gomez A.; Azevedo T.; Bacalini M.G.; Baldelli L.; Bartoletti-Stella A.; Bhatia K.P.; Marta B.-T.; Boninsegna C.; Broli M.; Dolores B.-R.; Calandra-Buonaura G.; Capellari S.; Carrion-Claro M.; Cilea R.; Clayton R.; Cortelli P.; Molin A.D.; De Luca S.; De Massis P.; Dimitri G.M.; Doykov I.; Escuela-Martin R.; Fabbri G.; Franceschi C.; Gabellini A.; Garagnani P.; Giuliani C.; Gomez-Garre P.; Guaraldi P.; Hagg S.; Hallqvist J.; Halsband C.; Heywood W.; Houlden H.; Huertas I.; Jesus S.; Jylhava J.; Labrador-Espinosa M.A.; Licari C.; Lio P.; Luchinat C.; Macias D.; Macri S.; Magrinelli F.; Rodriguez J.F.M.; Massimo D.; Maturo M.G.; Mengozzi G.; Meoni G.; Mignani F.; Milazzo M.; Mills K.; Mir P.; Mollenhauer B.; Nardini C.; Nassetti S.A.; Pedersen N.L.; Perinan-Tocino M.T.; Pirazzini C.; Provini F.; Ravaioli F.; Sala C.; Sambati L.; Scaglione C.L.M.; Schade S.; Schreglmann S.; Spasov S.; Strom S.; Tejera-Parrado C.; Tenori L.; Trenkwalder C.; Turano P.; Valzania F.; Ortega R.V.; Williams D.; Xumerle L.; Zago E.Zago E.; Dal Molin A.; Dimitri G.M.; Xumerle L.; Pirazzini C.; Bacalini M.G.; Maturo M.G.; Azevedo T.; Spasov S.; Gomez-Garre P.; Perinan M.T.; Jesus S.; Baldelli L.; Sambati L.; Calandra Buonaura G.; Garagnani P.; Provini F.; Cortelli P.; Mir P.; Trenkwalder C.; Mollenhauer B.; Franceschi C.; Lio P.; Nardini C.; Adarmes-Gomez A.; Azevedo T.; Bacalini M.G.; Baldelli L.; Bartoletti-Stella A.; Bhatia K.P.; Marta B.-T.; Boninsegna C.; Broli M.; Dolores B.-R.; Calandra-Buonaura G.; Capellari S.; Carrion-Claro M.; Cilea R.; Clayton R.; Cortelli P.; Molin A.D.; De Luca S.; De Massis P.; Dimitri G.M.; Doykov I.; Escuela-Martin R.; Fabbri G.; Franceschi C.; Gabellini A.; Garagnani P.; Giuliani C.; Gomez-Garre P.; Guaraldi P.; Hagg S.; Hallqvist J.; Halsband C.; Heywood W.; Houlden H.; Huertas I.; Jesus S.; Jylhava J.; Labrador-Espinosa M.A.; Licari C.; Lio P.; Luchinat C.; Macias D.; Macri S.; Magrinelli F.; Rodriguez J.F.M.; Massimo D.; Maturo M.G.; Mengozzi G.; Meoni G.; Mignani F.; Milazzo M.; Mills K.; Mir P.; Mollenhauer B.; Nardini C.; Nassetti S.A.; Pedersen N.L.; Perinan-Tocino M.T.; Pirazzini C.; Provini F.; Ravaioli F.; Sala C.; Sambati L.; Scaglione C.L.M.; Schade S.; Schreglmann S.; Spasov S.; Strom S.; Tejera-Parrado C.; Tenori L.; Trenkwalder C.; Turano P.; Valzania F.; Ortega R.V.; Williams D.; Xumerle L.; Zago E
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