Crossover between the Dense Electron-Hole Phase and the BCS Excitonic Phase in Quantum Dots

Second order perturbation theory and a Lipkin-Nogami scheme combined with an exact Monte Carlo projection after variation are applied to compute the ground-state energy of $6\le N\le 210$ electron-hole pairs confined in a parabolic two-dimensional quantum dot. The energy shows nice scaling properties as N or the confinement strength is varied. A crossover from the high-density electron-hole phase to the BCS excitonic phase is found at a density which is roughly four times the close-packing density of excitons.Comment: Improved variational and projection calculations. 17 pages, 3 ps figures. Accepted for publication in Int. J. Mod. Phys.

HIV Drug Resistance-Associated Mutations in Antiretroviral Naïve HIV-1-Infected Latin American Children

Our goal was to describe the presence of HIV drug resistance among HIV-1-infected, antiretroviral (ARV) naïve children and adolescents in Latin America and to examine resistance in these children in relation to drug exposure in the mother. Genotyping was performed on plasma samples obtained at baseline from HIV-1-infected participants in a prospective cohort study in Brazil, Argentina, and Mexico (NISDI Pediatric Study). Of 713 HIV-infected children enrolled, 69 were ARV naïve and eligible for the analysis. At enrollment, mean age was 7.3 years; 81.2% were infected with HIV perinatally. Drug resistance mutations (DRMs) were detected in 6 (8.7%; 95% confidence interval 3.1–18.2%) ARV-naïve subjects; none of the mothers of these 6 received ARVs during their pregnancies and none of the children received ARV prophylaxis. Reverse transcriptase mutations K70R and K70E were detected in 3 and 2 subjects, respectively; protease mutation I50 V was detected in 1 subject. Three of the 6 children with DRMs initiated ARV therapy during followup, with a good response in 2. The overall rate of primary drug resistance in this pediatric HIV-infected population was low, and no subjects had more than 1 DRM. Mutations associated with resistance to nucleoside reverse transcriptase inhibitors were the most prevalent

The effect of non-traditional cooling on dog sperm cryosurvival and ability to perform the acrosome reaction

The objective of this study was to assess cryosurvival, plasma membrane fluidity, and capability of cryopreserved dog (Canis lupus familiaris) spermatozoa, cooled to –5 °C before freezing, to perform the acrosome reaction under the effect of progesterone and calcium ionophore. In the first experiment, fresh spermatozoa diluted in Tyrode’s medium plus albumin, lactate, and pyruvate (TALP) were incubated at 38 °C in 5% CO2 in air, with progesterone or calcium ionophore added at 2, 4, and 6 h after incubation and sampled 30 min later to assess the acrosome reaction. In the second experiment, diluted sperm were packaged in plastic straws, cooled to either +5 °C or –5 °C and cryopreserved. Progressive motility, plasma membrane integrity and fluidity, capacitation status and acrosome integrity were assessed before and after freeze-thawing. After thawing, sperm were assessed, resuspended in TALP and incubated to assess the acrosome reaction. Parameters for sperm cryosurvival were similar in sperm cooled to either +5 °C or –5 °C, except in the percentage of hyper-fluid membranes which was lower (P<0.05) in sperm cooled to –5 °C. There were no differences in the percentages of frozen-thawed spermatozoa with acrosome reaction, induced by progesterone or calcium ionophore, between cooling treatments. In conclusion, cooling of dog spermatozoa to –5 °C did not improve sperm cryosurvival but had a positive effect on plasma membrane fluidity

A Cluster of Compact Radio Sources in NGC 2024 (Orion B)

We present deep 3.6 cm radio continuum observations of the H II region NGC 2024 in Orion B obtained using the Very Large Array in its A-configuration, with $0\rlap.{''}2$ angular resolution. We detect a total of 25 compact radio sources in a region of $4' \times 4'$. We discuss the nature of these sources and its relation with the infrared and X-ray objects in the region. At least two of the radio sources are obscured proplyds whose morphology can be used to restrict the location of the main ionizing source of the region. This cluster of radio sources is compared with others that have been found in regions of recent star formation.Comment: 21 pages, 7 figure

Distributing CMS Data between the Florida T2 and T3 Centers using Lustre and Xrootd-fs

We have developed remote data access for large volumes of data over the Wide Area Network based on the Lustre filesystem and Kerberos authentication for security. In this paper we explore a prototype for two-step data access from worker nodes at Florida Tier3 centers, located behind a firewall and using a private network, to data hosted on the Lustre filesystem at the University of Florida CMS Tier2 center. At the Tier3 center we use a client which mounts securely the Lustre filesystem and hosts an XrootD server. The worker nodes access the data from the Tier3 client using POSIX compliant tools via the XrootD-fs filesystem. We perform scalability tests with up to 200 jobs running in parallel on the Tier3 worker nodes

Oscillations and secondary bifurcations in nonlinear magnetoconvection

Complicated bifurcation structures that appear in nonlinear systems governed by partial differential equations (PDEs) can be explained by studying appropriate low-order amplitude equations. We demonstrate the power of this approach by considering compressible magnetoconvection. Numerical experiments reveal a transition from a regime with a subcritical Hopf bifurcation from the static solution, to one where finite-amplitude oscillations persist although there is no Hopf bifurcation from the static solution. This transition is associated with a codimension-two bifurcation with a pair of zero eigenvalues. We show that the bifurcation pattern found for the PDEs is indeed predicted by the second-order normal form equation (with cubic nonlinearities) for a Takens-Bogdanov bifurcation with Z2 symmetry. We then extend this equation by adding quintic nonlinearities and analyse the resulting system. Its predictions provide a qualitatively accurate description of solutions of the full PDEs over a wider range of parameter values. Replacing the reflecting (Z2) lateral boundary conditions with periodic [O(2)] boundaries allows stable travelling wave and modulated wave solutions to appear; they could be described by a third-order system

The Diagnostic Laboratory Hub: A New Health Care System Reveals the Incidence and Mortality of Tuberculosis, Histoplasmosis, and Cryptococcosis of PWH in Guatemala.

A Diagnostic Laboratory Hub (DLH) was set up in Guatemala to provide opportunistic infection (OI) diagnosis for people with HIV (PWH). Patients newly presenting for HIV, PWH not receiving antiretrovirals (ARVs) for >90 days but returned to care (Return/Restart), and PWH on ARVs with symptoms of OIs (ARV treatment) were prospectively included. Screening for tuberculosis, nontuberculous mycobacteria (NTM), histoplasmosis, and cryptococcosis was done. Samples were couriered to the DLH, and results were transmitted electronically. Demographic, diagnostic results, disease burden, treatment, and follow-up to 180 days were analyzed. In 2017, 1953 patients were included, 923 new HIV infections (an estimated 44% of all new HIV infections in Guatemala), 701 on ARV treatment, and 315 Return/Restart. Three hundred seventeen (16.2%) had an OI: 35.9% tuberculosis, 31.2% histoplasmosis, 18.6% cryptococcosis, 4.4% NTM, and 9.8% coinfections. Histoplasmosis was the most frequent AIDS-defining illness; 51.2% of new patients had <200 CD4 cells/mm3 with a 29.4% OI incidence; 14.3% of OIs in new HIV infections occurred with CD4 counts of 200-350 cells/mm3. OIs were the main risk factor for premature death for new HIV infections. At 180 days, patients with OIs and advanced HIV had 73-fold greater risk of death than those without advanced disease who were OI-free. The DLH OI screening approach provides adequate diagnostic services and obtains relevant data. We propose a CD4 screening threshold of <350 cells/mm3. Mortality remains high, and improved interventions are required, including expansion of the DLH and access to antifungal drugs, especially liposomal amphotericin B and flucytosine.Financial support. This work was supported by Global Action Fund for Fungal Infections and JYLAG, a charity Foundation based in Switzerland (E.A. received this funding under the proposal: “Minimising HIV deaths through rapid fungal diagnosis and better care in Guatemala”). Other contributions came from AIDS Health Foundation (AHF) Guatemala, Intrahealth International and Ministry of health in Guatemala (MSPAS).S