20 research outputs found
Oxidation of allylic and benzylic alcohols to aldehydes and carboxylic acids
An oxidation of allylic and benzylic alcohols to the corresponding carboxylic
acids is effected by merging a Cu-catalyzed oxidation using O2 as a terminal
oxidant with a subsequent chlorite oxidation (Lindgren oxidation). The
protocol was optimized to obtain pure products without chromatography or
crystallization. Interception at the aldehyde stage allowed for
Z/E-isomerization, thus rendering the oxidation stereoconvergent with respect
to the configuration of the starting material