13 research outputs found
Influence de la pression de l'air sur la vie de l'homme : climats de'altitude et climats de montagne
Vol. I ( [8] p., 654 p., [15] h. de map., [4] h. de lam.)los map. y lam. son litogr. : " Grave par Echard 12, r. Duguay-Trouin
Hypoxic regulation of erythropoiesis and iron metabolism
The kidney is a highly sensitive oxygen sensor and plays a central role in mediating the hypoxic induction of red blood cell production. Efforts to understand the molecular basis of oxygen-regulated erythropoiesis have led to the identification of erythropoietin (EPO), which is essential for normal erythropoiesis and to the purification of hypoxia-inducible factor (HIF), the transcription factor that regulates EPO synthesis and mediates cellular adaptation to hypoxia. Recent insights into the molecular mechanisms that control and integrate cellular and systemic erythropoiesis-promoting hypoxia responses and their potential as a therapeutic target for the treatment of renal anemia are discussed in this review