1,922 research outputs found
Endoscopic and clinical evaluation of treatment and prognosis of Cronkhite-Canada syndrome: a Japanese nationwide survey.
BackgroundFirst reported in 1955, Cronkhite-Canada syndrome (CCS), a rare syndrome characterized by ectodermal abnormalities and inflammatory changes of the gastrointestinal tract mucosa, has been associated with a poor prognosis and life-threatening malignant complications. In a large population survey, we endeavored to characterize the course and treatment outcome of CCS through clinical and endoscopic assessment, and to explore its optimal treatment and surveillance strategy.MethodsA retrospective analysis of 210 patients with CCS was conducted via a questionnaire-based nationwide survey of 983 teaching hospitals located throughout Japan. We assessed clinical features, endoscopic findings, treatments used, and short- and long-term outcomes.ResultsThe average age at diagnosis was 63.5 years. In all cases, upper or lower gastrointestinal tract polyposis was confirmed, accompanied by characteristic ectodermal abnormalities. Of the treatments used, oral corticosteroids (30-49 mg/day) were the most effective treatment for active disease, with adjunctive nutritional support considered beneficial. With corticosteroid treatment, abdominal symptoms were relieved within a few months, whereas polyp regression often required more than 6 months. Maintenance of endoscopic remission with or without steroids for 3 years significantly lowered the development of CCS-related cancer, compared with relapsers or nonresponders, underscoring the importance of sustained endoscopic remission for cancer prevention.ConclusionsThe prognosis of CCS has greatly improved through the use of improved medical treatment. Although CCS continues to be relentlessly progressive, carrying a high cancer risk, a sufficient dose and duration of corticosteroid therapy accompanied by nutritional support and periodic endoscopic surveillance appears to improve its natural history
Unimodality Problems in Ehrhart Theory
Ehrhart theory is the study of sequences recording the number of integer
points in non-negative integral dilates of rational polytopes. For a given
lattice polytope, this sequence is encoded in a finite vector called the
Ehrhart -vector. Ehrhart -vectors have connections to many areas of
mathematics, including commutative algebra and enumerative combinatorics. In
this survey we discuss what is known about unimodality for Ehrhart
-vectors and highlight open questions and problems.Comment: Published in Recent Trends in Combinatorics, Beveridge, A., et al.
(eds), Springer, 2016, pp 687-711, doi 10.1007/978-3-319-24298-9_27. This
version updated October 2017 to correct an error in the original versio
Fezl Is Required for the Birth and Specification of Corticospinal Motor Neurons
SummaryThe molecular mechanisms controlling the differentiation of neural progenitors into distinct subtypes of neurons during neocortical development are unknown. Here, we report that Fezl is required for the specification of corticospinal motor neurons and other subcerebral projection neurons, which are absent from Fezl null mutant neocortex. There is neither an increase in cell death in Fezl−/− cortex nor abnormalities in migration, indicating that the absence of subcerebral projection neurons is due to a failure in fate specification. In striking contrast, other neuronal populations in the same and other cortical layers are born normally. Overexpression of Fezl results in excess production of subcerebral projection neurons and arrested migration of these neurons in the germinal zone. These data indicate that Fezl plays a central role in the specification of corticospinal motor neurons and other subcerebral projection neurons, controlling early decisions regarding lineage-specific differentiation from neural progenitors
On the structure of the h-vector of a paving matroid.
We give two proofs that the h-vector of any paving matroid is a pure 0-sequence, thus answering in the affirmative a conjecture made by Stanley, for this particular class of matroids. We also investigate the problem of obtaining good lower bounds for the number of bases of a paving matroid given its rank and number of elements.The first author was supported by Conacyt of México Proyect8397
Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases.
Relative blocking in posets
Poset-theoretic generalizations of set-theoretic committee constructions are
presented. The structure of the corresponding subposets is described. Sequences
of irreducible fractions associated to the principal order ideals of finite
bounded posets are considered and those related to the Boolean lattices are
explored; it is shown that such sequences inherit all the familiar properties
of the Farey sequences.Comment: 29 pages. Corrected version of original publication which is
available at http://www.springerlink.com, see Corrigendu
On Witten multiple zeta-functions associated with semisimple Lie algebras IV
In our previous work, we established the theory of multi-variable Witten
zeta-functions, which are called the zeta-functions of root systems. We have
already considered the cases of types , , , and . In
this paper, we consider the case of -type. We define certain analogues of
Bernoulli polynomials of -type and study the generating functions of them
to determine the coefficients of Witten's volume formulas of -type. Next
we consider the meromorphic continuation of the zeta-function of -type and
determine its possible singularities. Finally, by using our previous method, we
give explicit functional relations for them which include Witten's volume
formulas.Comment: 22 pag
Few smooth d-polytopes with n lattice points
We prove that, for fixed n there exist only finitely many embeddings of
Q-factorial toric varieties X into P^n that are induced by a complete linear
system. The proof is based on a combinatorial result that for fixed nonnegative
integers d and n, there are only finitely many smooth d-polytopes with n
lattice points. We also enumerate all smooth 3-polytopes with at most 12
lattice points. In fact, it is sufficient to bound the singularities and the
number of lattice points on edges to prove finiteness.Comment: 20+2 pages; major revision: new author, new structure, new result
Blockade of T-cell activation by dithiocarbamates involves novel mechanisms of inhibition of nuclear factor of activated T cells.
Dithiocarbamates (DTCs) have recently been reported as powerful inhibitors of NF-kappaB activation in a number of cell types. Given the role of this transcription factor in the regulation of gene expression in the inflammatory response, NF-kappaB inhibitors have been suggested as potential therapeutic drugs for inflammatory diseases. We show here that DTCs inhibited both interleukin 2 (IL-2) synthesis and membrane expression of antigens which are induced during T-cell activation. This inhibition, which occurred with a parallel activation of c-Jun transactivating functions and expression, was reflected by transfection experiments at the IL-2 promoter level, and involved not only the inhibition of NF-kappaB-driven reporter activation but also that of nuclear factor of activated T cells (NFAT). Accordingly, electrophoretic mobility shift assays (EMSAs) indicated that pyrrolidine DTC (PDTC) prevented NF-kappaB, and NFAT DNA-binding activity in T cells stimulated with either phorbol myristate acetate plus ionophore or antibodies against the CD3-T-cell receptor complex and simultaneously activated the binding of AP-1. Furthermore, PDTC differentially targeted both NFATp and NFATc family members, inhibiting the transactivation functions of NFATp and mRNA induction of NFATc. Strikingly, Western blotting and immunocytochemical experiments indicated that PDTC promoted a transient and rapid shuttling of NFATp and NFATc, leading to their accelerated export from the nucleus of activated T cells. We propose that the activation of an NFAT kinase by PDTC could be responsible for the rapid shuttling of the NFAT, therefore transiently converting the sustained transactivation of this transcription factor that occurs during lymphocyte activation, and show that c-Jun NH2-terminal kinase (JNK) can act by directly phosphorylating NFATp. In addition, the combined inhibitory effects on NFAT and NF-KB support a potential use of DTCs as immunosuppressants
Decomposition of semigroup algebras
Let A \subseteq B be cancellative abelian semigroups, and let R be an
integral domain. We show that the semigroup ring R[B] can be decomposed, as an
R[A]-module, into a direct sum of R[A]-submodules of the quotient ring of R[A].
In the case of a finite extension of positive affine semigroup rings we obtain
an algorithm computing the decomposition. When R[A] is a polynomial ring over a
field we explain how to compute many ring-theoretic properties of R[B] in terms
of this decomposition. In particular we obtain a fast algorithm to compute the
Castelnuovo-Mumford regularity of homogeneous semigroup rings. As an
application we confirm the Eisenbud-Goto conjecture in a range of new cases.
Our algorithms are implemented in the Macaulay2 package MonomialAlgebras.Comment: 12 pages, 2 figures, minor revisions. Package may be downloaded at
http://www.math.uni-sb.de/ag/schreyer/jb/Macaulay2/MonomialAlgebras/html
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