Automatic recognition of schwa variants in spontaneous Hungarian speech

This paper analyzes the nature of the process involved in optional vowel reduction in Hungarian, and the acoustic structure of schwa variants in spontaneous speech. The study focuses on the acoustic patterns of both the basic realizations of Hungarian vowels and their realizations as neutral vowels (schwas), as well as on the design, implementation, and evaluation of a set of algorithms for the recognition of both types of realizations from the speech waveform. The authors address the question whether schwas form a unified group of vowels or they show some dependence on the originally intended articulation of the vowel they stand for. The acoustic study uses a database consisting of over 4,000 utterances extracted from continuous speech, and recorded from 19 speakers. The authors propose methods for the recognition of neutral vowels depending on the various vowels they replace in spontaneous speech. Mel-Frequency Cepstral Coefficients are calculated and used for the training of Hidden Markov Models. The recognition system was trained on 2,500 utterances and then tested on 1,500 utterances. The results show that a neutral vowel can be detected in 72% of all occurrences. Stressed and unstressed syllables can be distinguished in 92% of all cases. Neutralized vowels do not form a unified group of phoneme realizations. The pronunciation of schwa heavily depends on the original articulation configuration of the intended vowel

Features of Mild-to-Moderate COVID-19 Patients with Dysphonia

Introduction To explore the prevalence of dysphonia in European patients with mild-to-moderate COVID-19 and the clinical features of dysphonic patients. Methods The clinical and epidemiological data of 702 patients with mild-to-moderate COVID-19 were collected from 19 European Hospitals. The following data were extracted: age, sex, ethnicity, tobacco consumption, comorbidities, general and otolaryngological symptoms. Dysphonia and otolaryngological symptoms were self-assessed through a 4-point scale. The prevalence of dysphonia, as part of the COVID-19 symptoms, was assessed. The outcomes were compared between dysphonic and non-dysphonic patients. The association between dysphonia severity and outcomes was studied through Bayesian analysis. Results A total of 188 patients were dysphonic, accounting for 26.8% of cases. Females developed more frequently dysphonia than males (p=0.022). The proportion of smokers was significantly higher in the dysphonic group (p=0.042). The prevalence of the following symptoms was higher in dysphonic patients compared with non-dysphonic patients: cough, chest pain, sticky sputum, arthralgia, diarrhea, headache, fatigue, nausea and vomiting. The severity of dyspnea, dysphagia, ear pain, face pain, throat pain and nasal obstruction was higher in dysphonic group compared with non-dysphonic group. There were significant associations between the severity of dysphonia, dysphagia and cough. Conclusion Dysphonia may be encountered in a quarter of patients with mild-to-moderate COVID-19 and should be considered as a symptom list of the infection. Dysphonic COVID-19 patients are more symptomatic than non-dysphonic individuals. Future studies are needed to investigate the relevance of dysphonia in the COVID-19 clinical presentation

A Ligand Peptide Motif Selected from a Cancer Patient Is a Receptor-Interacting Site within Human Interleukin-11

Interleukin-11 (IL-11) is a pleiotropic cytokine approved by the FDA against chemotherapy-induced thrombocytopenia. From a combinatorial selection in a cancer patient, we isolated an IL-11-like peptide mapping to domain I of the IL-11 (sequence CGRRAGGSC). Although this motif has ligand attributes, it is not within the previously characterized interacting sites. Here we design and validate in-tandem binding assays, site-directed mutagenesis and NMR spectroscopy to show (i) the peptide mimics a receptor-binding site within IL-11, (ii) the binding of CGRRAGGSC to the IL-11Rα is functionally relevant, (iii) Arg4 and Ser8 are the key residues mediating the interaction, and (iv) the IL-11-like motif induces cell proliferation through STAT3 activation. These structural and functional results uncover an as yet unrecognized receptor-binding site in human IL-11. Given that IL-11Rα has been proposed as a target in human cancer, our results provide clues for the rational design of targeted drugs

Formants frequencies variability in French vowels under the effect of various speaking styles

The paper presents first results of a research aiming at a more refined definition of the so-called speaking styles. A speaker is recorded in 6 situations and the formants of his /i/, /a/ and /u/ vowels are studied. New categorizations of the speaking styles are proposed, on the basis of the similarities and dissimilarities in formant frequencies values drawn from the various communication situations

VARIATIONS STRUCTURELLES DES SYSTÈMES VOCALIQUES EN FRANÇAIS ET ESPAGNOL SOUS L'EFFET DU STYLE DE PAROLE

The paper analyzes utterances of the French and Spanish vowels both in spontaneous- and laboratory speech. These changes in speaking styles modify the vowels formants. In spanish, both centralization and increased probability of inter vowel confusion are observed. In French, decreased differenciation is observed as well, but without clear centralization tendencies.La communication analyse des réalisations de voyelles françaises et espagnoles en parole spontanée et en parole de laboratoire. Ces changements de style modifient les formants vocaliques. En espagnol, on constate à la fois centralisation et tendance à la confusion entre voyelles. En français, une baisse de la différenciation est également observable, mais en l'absence de tendances centralisantes nettes

Heat flow in the Sea of Marmara Central Basin: Possible implications for the tectonic evolution of the North Anatolian fault,

International audienceThe Central Basin in the Sea of Marmara is a syntectonic basin related to the evolution of the North Anatolian fault. A well-dated (ca. 15.5-16 ka) homogenite sediment can be used as a marker in three-dimensional depth model calculations, allowing a precise determination of the seafloor subsidence rates during the Holocene. A steady-state model based on the propagation of the rates downward through the basin fill provides a good correlation with the deeper seismic reflection imagery for the past 250 ka but indicates variation of subsidence pattern for older ages. Heat flow measured at the seafloor is affected by sedimentation blanketing effects. Heat flow and subsidence data can only be reconciled if the Central Basin depocenter migrated northward with time. According to that scenario, subsidence and deposition started earlier (ca. 5-3.5 Ma) in the southern subbasin, and an acceleration of subsidence in the northern subbasin occurred at ca. 2.5-1.5 Ma. These results allow us to propose that a southern fault system distinct from the Main Marmara fault is responsible for the southern onset of the subsidence. Changes in the fault network and slip rates are implied during the last 2.5-1.5 Ma despite no apparent change since 250 ka