78 research outputs found

    Interaction effects on galaxy pairs with Gemini/GMOS- II: Oxygen abundance gradients

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    In this paper we derived oxygen abundance gradients from HII regions located in eleven galaxies in eight systems of close pairs. Long-slit spectra in the range 4400-7300A were obtained with the Gemini Multi-Object Spec- trograph at Gemini South (GMOS). Spatial profiles of oxygen abundance in the gaseous phase along galaxy disks were obtained using calibrations based on strong emission-lines (N2 and O3N2). We found oxygen gradients signifi- cantly flatter for all the studied galaxies than those in typical isolated spiral galaxies. Four objects in our sample, AM1219A, AM1256B, AM 2030A and AM2030B, show a clear break in the oxygen abundance at galactocentric radius R/R25 between 0.2 and 0.5. For AM1219A and AM1256B we found negative slopes for the inner gradients, and for AM2030B we found a positive one. In all these three cases they show a flatter behaviour to the outskirts of the galaxies. For AM2030A, we found a positive-slope outer gradient while the inner one is almost compatible with a flat behaviour. A decrease of star forma- tion efficiency in the zone that corresponds to the oxygen abundance gradient break for AM1219A and AM2030B was found. For the former, a minimum in the estimated metallicities was found very close to the break zone that could be associated with a corotation radius. On the other hand, AM1256B and AM2030A, present a SFR maximum but not an extreme oxygen abundance value. All the four interacting systems that show oxygen gradient breakes the extreme SFR values are located very close to break zones. Hii regions lo- cated in close pairs of galaxies follow the same relation between the ionization parameter and the oxygen abundance as those regions in isolated galaxies.Comment: 30 pages, 14 figures, accepted MNRAS, (Figs. 1 and 2 are in low resolution

    Photo-Induced Spin Dynamics in Semiconductor Quantum Wells

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    We experimentally investigate the dynamics of spins in GaAs quantum wells under applied electric bias by photoluminescence (PL) measurements excited with circularly polarized light. The bias-dependent circular polarization of PL (PPL) with and without magnetic field is studied. ThePPLwithout magnetic field is found to be decayed with an enhancement of increasing the strength of the negative bias. However,PPLin a transverse magnetic field shows oscillations under an electric bias, indicating that the precession of electron spin occurs in quantum wells. The results are discussed based on the electron–hole exchange interaction in the electric field

    From Pioneer to Repressor: Bimodal foxd3 Activity Dynamically Remodels Neural Crest Regulatory Landscape In Vivo

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    The neural crest (NC) is a transient embryonic stem cell-like population characterized by its multipotency and broad developmental potential. Here, we perform NC-specific transcriptional and epigenomic profiling of foxd3-mutant cells in vivo to define the gene regulatory circuits controlling NC specification. Together with global binding analysis obtained by foxd3 biotin-ChIP and single cell profiles of foxd3-expressing premigratory NC, our analysis shows that, during early steps of NC formation, foxd3 acts globally as a pioneer factor to prime the onset of genes regulating NC specification and migration by re-arranging the chromatin landscape, opening cis-regulatory elements and reshuffling nucleosomes. Strikingly, foxd3 then gradually switches from an activator to its well-described role as a transcriptional repressor and potentially uses differential partners for each role. Taken together, these results demonstrate that foxd3 acts bimodally in the neural crest as a switch from "permissive" to "repressive" nucleosome and chromatin organization to maintain multipotency and define cell fates

    Late Replication Domains in Polytene and Non-Polytene Cells of Drosophila melanogaster

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    In D. melanogaster polytene chromosomes, intercalary heterochromatin (IH) appears as large dense bands scattered in euchromatin and comprises clusters of repressed genes. IH displays distinctly low gene density, indicative of their particular regulation. Genes embedded in IH replicate late in the S phase and become underreplicated. We asked whether localization and organization of these late-replicating domains is conserved in a distinct cell type. Using published comprehensive genome-wide chromatin annotation datasets (modENCODE and others), we compared IH organization in salivary gland cells and in a Kc cell line. We first established the borders of 60 IH regions on a molecular map, these regions containing underreplicated material and encompassing ∼12% of Drosophila genome. We showed that in Kc cells repressed chromatin constituted 97% of the sequences that corresponded to IH bands. This chromatin is depleted for ORC-2 binding and largely replicates late. Differences in replication timing between the cell types analyzed are local and affect only sub-regions but never whole IH bands. As a rule such differentially replicating sub-regions display open chromatin organization, which apparently results from cell-type specific gene expression of underlying genes. We conclude that repressed chromatin organization of IH is generally conserved in polytene and non-polytene cells. Yet, IH domains do not function as transcription- and replication-regulatory units, because differences in transcription and replication between cell types are not domain-wide, rather they are restricted to small “islands” embedded in these domains. IH regions can thus be defined as a special class of domains with low gene density, which have narrow temporal expression patterns, and so displaying relatively conserved organization

    Transcriptome Analysis of the Desert Locust Central Nervous System: Production and Annotation of a Schistocerca gregaria EST Database

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    ) displays a fascinating type of phenotypic plasticity, designated as ‘phase polyphenism’. Depending on environmental conditions, one genome can be translated into two highly divergent phenotypes, termed the solitarious and gregarious (swarming) phase. Although many of the underlying molecular events remain elusive, the central nervous system (CNS) is expected to play a crucial role in the phase transition process. Locusts have also proven to be interesting model organisms in a physiological and neurobiological research context. However, molecular studies in locusts are hampered by the fact that genome/transcriptome sequence information available for this branch of insects is still limited. EST information is highly complementary to the existing orthopteran transcriptomic data. Since many novel transcripts encode neuronal signaling and signal transduction components, this paper includes an overview of these sequences. Furthermore, several transcripts being differentially represented in solitarious and gregarious locusts were retrieved from this EST database. The findings highlight the involvement of the CNS in the phase transition process and indicate that this novel annotated database may also add to the emerging knowledge of concomitant neuronal signaling and neuroplasticity events. EST data constitute an important new source of information that will be instrumental in further unraveling the molecular principles of phase polyphenism, in further establishing locusts as valuable research model organisms and in molecular evolutionary and comparative entomology

    Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation

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