22,547 research outputs found

    Study program of local angle-of-attack effects on vehicle dynamic response Final report

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    Effects of flexible body aerodynamics on launch vehicle

    Genome-wide association study for calving performance using high-density genotypes in dairy and beef cattle

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    peer-reviewedBackground Calving difficulty and perinatal mortality are prevalent in modern-day cattle production systems. It is well-established that there is a genetic component to both traits, yet little is known about their underlying genomic architecture, particularly in beef breeds. Therefore, we performed a genome-wide association study using high-density genotypes to elucidate the genomic architecture of these traits and to identify regions of the bovine genome associated with them. Results Genomic regions associated with calving difficulty (direct and maternal) and perinatal mortality were detected using two statistical approaches: (1) single-SNP (single nucleotide polymorphism) regression and (2) a Bayesian approach. Data included high-density genotypes on 770 Holstein-Friesian, 927 Charolais and 963 Limousin bulls. Several novel or previously identified genomic regions were detected but associations differed by breed. For example, two genomic associations, one each on chromosomes 18 and 2 explained 2.49 % and 3.13 % of the genetic variance in direct calving difficulty in the Holstein-Friesian and Charolais populations, respectively. Imputed Holstein-Friesian sequence data was used to refine the genomic regions responsible for significant associations. Several candidate genes on chromosome 18 were identified and four highly significant missense variants were detected within three of these genes (SIGLEC12, CTU1, and ZNF615). Nevertheless, only CTU1 contained a missense variant with a putative impact on direct calving difficulty based on SIFT (0.06) and Polyphen (0.95) scores. Using imputed sequence data, we refined a genomic region on chromosome 4 associated with maternal calving difficulty in the Holstein-Friesian population and found the strongest association with an intronic variant in the PCLO gene. A meta-analysis was performed across the three breeds for each calving performance trait to identify common variants associated with these traits in the three breeds. Our results suggest that a portion of the genetic variation in calving performance is common to all three breeds. Conclusion The genomic architecture of calving performance is complex and mainly influenced by many polymorphisms of small effect. We identified several associations of moderate effect size but the majority were breed-specific, indicating that breed-specific alleles exist for calving performance or that the linkage phase between genotyped allele and causal mutation varies between breeds

    Ground-State Properties of a Rotating Bose-Einstein Condensate with Attractive Interaction

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    The ground state of a rotating Bose-Einstein condensate with attractive interaction in a quasi-one-dimensional torus is studied in terms of the ratio γ\gamma of the mean-field interaction energy per particle to the single-particle energy-level spacing. The plateaus of quantized circulation are found to appear if and only if γ<1\gamma<1 with the lengths of the plateaus reduced due to hybridization of the condensate over different angular-momentum states.Comment: 4 pages, 2 figures, Accepted for publication in Physical Reveiw Letter

    Odd Parity and Line Nodes in Non-Symmorphic Superconductors

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    Group theory arguments have been invoked to argue that odd parity order parameters cannot have line nodes in the presence of spin-orbit coupling. In this paper we show that these arguments do not hold for certain non-symmorphic superconductors. Specifically, we demonstrate that when the underlying crystal has a twofold screw axis, half of the odd parity representations vanish on the Brillouin zone face perpendicular to this axis. Many unconventional superconductors have non-symmorphic space groups, and we discuss implications for several materials, including UPt3, UBe13, Li2Pt3B and Na4Ir3O8.Comment: 4 page
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