Does the application of directive 2001/93/EC improve pigs welfare and productive performances?

Recently, with the aim to protect swine and enhance their welfare, a set of international rules has been approved by the European Commission (directive 91/630/CEE; 2001/88 CEE; 2001/93/CEE). These ..

Mortars and screeds containing polymeric aggregates recycled from industrial waste and tyres

Given the growing market demand for products containing recycled components dictated by European and national policies, the presented research aimed to replace part of the natural aggregates in construction mortars and screeds with recycled polymeric aggregates (RA): industrial technopolymers and ground tyre rubber (GTR). The strategy involved the substitution of aggregates, both in market products and in the design of standard mortars, first verifying the CE certification and then the achievable mechanical performance. The whole process has been discussed in the context of a circular approach, extended to the analysis of the aggregate production phase, highlighting factors that influence environmental and economic impacts

Alignment of the ISAC-II Medium Beta Cryomodule with a Wire Monitoring System

Publisher Summary This chapter discusses a system that has been designed to monitor changes in the alignment of the cavities and solenoids during pump out and cool down. TRIUMF is developing ISAC-II, a superconducting (SC) linac. It will comprise 9 cryomodules with a total of 48 niobium cavities and 12 SC solenoids. They must remain aligned at liquid He temperatures: cavities to ±400 μm and solenoids to ±200 μm after a vertical contraction of ∼4 mm. A wire position monitor (WPM) system based on a TESLA design measures the signals induced in stripline pickups by a 215 MHz signal carded by a position reference wire. The sensors, one per cavity and two per solenoid, monitor their motion during pre-alignment, pumping, and cool down. System accuracy is ∼7 μm. The device is giving a wealth of information over and above the data collected with the installed optical targets. The use of optical targets involves personnel and the readings can be taken only periodically. Conversely the WPM data is monitored continuously providing detailed data that is extremely valuable to help characterize a new structure

XIII International Conference on Computational Plasticity. Fundamentals and Applications -COMPLAS XIII

ABSTRACT Landslides can cause major economic damage and a large number of casualties as it is possible to see from past events occurred all over the world. Being able to predict these kind of hazards would then suppose the achievement of great benefits. Here a model that combines a depth integrated description of the soil-pore fluid mixture together with a set of 1D models dealing with pore pressure evolution within the soil mass is presented. In this way, pore pressure changes caused by vertical consolidation, changes of total stresses resulting from height variations and changes of basal surface permeability can be taken into account with more precision. The mathematical model is based on the Biot-Zienkiewicz equations, from where a depth averaged model is derived. Concerning the material behaviour, the approach used is the one suggested by the Perzyna viscoplasticity, which has been extensively used in the past to model solid behaviour prior to failure. Three different yield criterion are considered in the framework of Perzyna's model: a Von Mises, a Mohr Coulomb and a Cam Clay yield criterion. The obtained results lead to a good agreement with the results achieved using classical rheological models. Then, a simple shear rheological model is derived, providing the basal friction needed in depth integrated models. The Smoothed Particle Hydrodynamics (SPH) has been the numerical technique chosen to spatially discretised the depth integrated equations of the mathematical model. The SPH technique has been enriched by adding a 1D finite differences grid associated at each SPH node in order to improve the description of pore water profiles in the avalanching soil. The purpose of this work is to apply the SPH depth integrated numerical model, together with the sub-model that predicts the evolution of the pore water pressure inside the landslide, to simulate the propagation phase of the Aberfan flowslide occurred in 1966. REFERENCES [1] M. Pastor, M

Pathway-specific effects of ADSL deficiency on neurodevelopment

Adenylosuccinate lyase (ADSL) functions in de novo purine synthesis (DNPS) and the purine nucleotide cycle. ADSL deficiency (ADSLD) causes numerous neurodevelopmental pathologies, including microcephaly and autism spectrum disorder. ADSLD patients have normal serum purine nucleotide levels but exhibit accumulation of dephosphorylated ADSL substrates, S-Ado, and SAICAr, the latter being implicated in neurotoxic effects through unknown mechanisms. We examined the phenotypic effects of ADSL depletion in human cells and their relation to phenotypic outcomes. Using specific interventions to compensate for reduced purine levels or modulate SAICAr accumulation, we found that diminished AMP levels resulted in increased DNA damage signaling and cell cycle delays, while primary ciliogenesis was impaired specifically by loss of ADSL or administration of SAICAr. ADSL-deficient chicken and zebrafish embryos displayed impaired neurogenesis and microcephaly. Neuroprogenitor attrition in zebrafish embryos was rescued by pharmacological inhibition of DNPS, but not increased nucleotide concentration. Zebrafish also displayed phenotypes commonly linked to ciliopathies. Our results suggest that both reduced purine levels and impaired DNPS contribute to neurodevelopmental pathology in ADSLD and that defective ciliogenesis may influence the ADSLD phenotypic spectrum.ID was funded by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no. 754510, THS, JL, and SP were funded by the Ministry of Science, Innovation and Universities (MCIU; PGC2018-095616-B-I00 to THS, PGC2018-099562-B-I00 to JL, and BFU2017-83562-P to SP), the 2017 SGR 1089 (AGAUR), FEDER, the Centres of Excellence Severo Ochoa award, and the CERCA Programme. THS was supported by the NIH Intramural Research Program, National Cancer Institute, Center for Cancer Research. MP was funded by grants from the Deutsche Forschungsgemeinschaft (DFG PH144/4-1 and PH144/6-1). MZ, OS, and VS were supported by Charles University, program PROGRES Q26/LF1. We would like to thank Biocev, First Faculty of Medicine, Charles University, for the opportunity to use their department’s equipment

Análisis de requerimientos y determinación preliminar de la potencia de actuación para el TVC de un vehículo lanzador con tobera flexible

En los vehículos lanzadores se requiere de un sistema de control de dirección del vector de empuje (TVC) que permita desarrollar un vuelo a lo largo de una trayectoria programada, así como también compensar las perturbaciones que se presenten durante la fase propulsiva. Existen distintos mecanismos para lograr este objetivo, siendo uno de los más utilizados el basado en modificar la dirección de la tobera de empuje. En el caso de combustibles sólidos, la tobera incluye una junta flexible conformada mediante la unión de un elastómero con aros de acero que posibilita ajustar la orientación del eje de empuje, mediante un actuador lineal montado de manera conveniente entre la tobera y la estructura del vehículo, el que provoca la deformación elástica de la junta. Se abordará la problemática de utilizar un actuador electromecánico (AEM), basado en tecnología de un motor eléctrico sin escobillas (brushless), para conformar el sistema de control de orientación de una tobera flexible. Dichas toberas imponen fuertes requerimientos operativos a los sistemas de actuación, debido a los elevados valores de rigidez y rozamiento que presentan. En lo metodológico se ha procedido formulando el modelo matemático mecánico, con el que se llevó a cabo la simulación numérica de funcionamiento empleando software especializado de acuerdo a los requerimientos impuestos para determinar a priori las potencias requeridas para los diferentes casos de maniobras planteados. Luego, en las condiciones de peor caso, se pasó a optimizar la relación de transmisión teniendo asimismo en cuenta los requerimientos de respuesta en frecuencia para condiciones de funcionamiento lineal.www.caim2014.unne.edu.arFil: Salomone, Javier E. Centro de Investigaciones Aplicadas. Departamento Sistemas Electromecánicos; Argentina.Fil: Pedroni, Juan P. Centro de Investigaciones Aplicadas. Departamento Sistemas Electromecánicos; Argentina.Fil: Jazni, Jorge E. Centro de Investigaciones Aplicadas. Departamento Sistemas Electromecánicos; Argentina.Fil: Dutto, Esteban A. Centro de Investigaciones Aplicadas. Departamento Sistemas Electromecánicos; Argentina.Fil: Cova, Walter J. D. Centro de Investigaciones Aplicadas. Departamento Sistemas Electromecánicos; Argentina.Fil: Lagier, Santiago. Centro de Investigaciones Aplicadas. Departamento Sistemas Electromecánicos; Argentina.Ingeniería Aeroespacia

Research On The Legal Issues Of Domestic Enterprises For Overseas Stock Market Listing ——From The Perspective Of VIE Agreements

2011年发生的“支付宝股权转移事件”引发了各界对我国境内公司以协议控制模式在境外上市法律问题的广泛关注。协议控制模式最初是为规避外商投资产业准入政策而设计，其合法性至今还存有很大的争议。本文从相关概念的界定入手，介绍了境内企业以协议控制模式在境外上市的操作方式，分析了导致协议控制模式存在和发展的法律动因及其存在的问题，在此基础上，对如何解决其存在的问题提出了几点建议。 本文分为引言、正文、结论三部分。其中正文共分为四章： 第一章从相关概念的界定入手，对协议控制上市模式进行分析。 第二章分析了境内企业以协议控制模式境外上市的法律动因主要是：规避外资行业准入政策；规避商务部关联并购的审批程...The Alipay’s transfer of ownership in 2011 draws public attention to legal defects of domestic enterprises for overseas stock market listing by VIE agreements . VIE agreements aims to avoid industry access policy to foreign merchants at first, which arouse controversy about its legitimacy until now. This paper begins to illustrates the conception of VIE agreements, followed by the operating ways a...学位：法律硕士院系专业：法学院法律系_法律硕士(JM)学号：1302009115033

Laser-induced phase separation of silicon carbide

Understanding the phase separation mechanism of solid-state binary compounds induced by laser-material interaction is a challenge because of the complexity of the compound materials and short processing times. Here we present xenon chloride excimer laser-induced melt-mediated phase separation and surface reconstruction of single-crystal silicon carbide and study this process by high-resolution transmission electron microscopy and a time-resolved reflectance method. A single-pulse laser irradiation triggers melting of the silicon carbide surface, resulting in a phase separation into a disordered carbon layer with partially graphitic domains (???2.5 nm) and polycrystalline silicon (???5 nm). Additional pulse irradiations cause sublimation of only the separated silicon element and subsequent transformation of the disordered carbon layer into multilayer graphene. The results demonstrate viability of synthesizing ultra-thin nanomaterials by the decomposition of a binary system.open