Studying the effects of virtual biodiversity research infrastructures

Abstract. The research environment of scholars is increasingly web-based. This makes it urgent to study the effects of moving to the Web on research practices, scholarly output and innovation. We propose a theoretical framework and a methodology to study these effects. In a pilot study, we apply theory and method on an online community in biodiversity research, to demonstrate the feasibility of the approach. We also indicate the practical relevance of this kind of analysis for improving the quality of virtual research environments. In the last section, directions for further research are suggested

Circles of Peace. A Video Analysis of Situational Group Formation and Collective Third-Party Intervention in Violent Incidents

We seek to understand collective third-party intervention in violent incidents. Based on analyses of 131 video clips captured on mobile phones, we argue that bodily alignment between bystanders creates situational groups that encourage collective de-escalatory action. Qualitative analysis reveals that third parties generate situational groups when they create circular formations, providing greater opportunities to notice each other’s monitoring of the situation while separating those focused on the incident from others just passing by. Statistical analysis shows that the formation of situational groups facilitates the collectivization of de-escalatory action. In contrast to popular but outdated ideas about the dangerous influence of assemblies on individual behaviour (allegedly leading to disorder or apathy), our findings emphasize the self-regulatory, defusing capacity of gatherings

Carbapenem-resistant Enterobacteriaceae: What we know and what we need to know

Infections caused by carbapenem-resistant Enterobacteriaceae (CRE) are a significant cause of morbidity and mortality worldwide. CRE are defined by the Centers for Disease Control and Prevention (CDC) as those Enterobacteriaceae that are resistant in vitro to any carbapenem antimicrobial. This means a minimum inhibitory concentration (MIC) of ≥ 2 mg/ml for ertapenem, or an MIC ≥ 4 mg/ml for doripenem, meropenem, or imipenem. In addition, those Enterobacteriaceae that are documented to produce a carbapenemase are also considered CRE, regardless of carbapenem MIC. For Enterobacteriaceae species that have intrinsic imipenem resistance – such as Morganella morganii, Proteus spp. and Providencia spp – resistance to carbapenems other than imipenem is required.2 This phenotypic definition includes both carbapenemase-producing Enterobacteriaceae (CPE or CP-CRE) as well as non-carbapenemase-producing CRE. A retrospective study evaluating the impact of carbapenemase production on outcomes after monomicrobial CRE bloodstream infections (BSI) found that patients infected with CP-CRE were at increased risk of dying within 14 d as compared with patients with non-carbapenemase-producing CRE (adjusted odds ratio, 4.92; 95% confidence interval 1.01–24.81). The authors speculated that increased virulence of CP-CRE rather than patient factors were the cause of this observation

Which Energy Security Union?:An experiment on public preferences for energy union alternatives in 5 western European countries.

The Russian invasion of Ukraine caught the European Union (EU) off-balance, leading some to propose a relaunch of the EU's Energy Union. However, the political feasibility of such programmes remains disputed, and any such policy design is inherently multidimensional with respect to scope, governance, source of financing and other dimensions. To determine public support for energy security cooperation, we conduct a (first ever) conjoint experiment on public support for alternative energy union designs, fielded among a highly representative sample of the French, German, Italian, Dutch and Spanish populations in November 2022. This multidimensional conjoint experiment allows us to determine the causal link between (hypothetical) policy features of potential energy solidarity pacts, and public support or opposition to such policy. Our results show that policy packages receiving the most support have higher levels of ambition, joint EU-level governance, joint purchases and procurement. All-in-all our results reveal considerable cross-border support for energy solidarity, indicating that a compromise policy is feasible and publicly supported. Furthermore, our results suggest that European citizens are willing to support the creation of joint institutions to face issues of common concern, suggesting that major crises open windows of opportunity to re-shape European integration

Carbapenemase-producing organisms in solid organ transplantation

Purpose of review Carbapenem-resistant enterobacteriaceae (CRE) are a critical healthcare threat. Infections caused by CRE disproportionately affect transplant patients. Retrospective case studies suggest that up to 10% of transplant recipients develop a CRE infection. The current literature is reviewed with a particular focus on transplant-specific implications. Recent findings There are specific risks inherent to transplant recipients that result in an elevated risk for CRE carriage and subsequent infection. Additionally, the manifestations of these infections are dependent on the specific transplant type. The optimal treatment of CRE infections in transplant recipients has not been defined. Summary A reduction in the regional community CRE burden can lead to a secondary reduction in their occurrence within vulnerable transplant populations. Therefore, core principles of antibiotic stewardship and infection control within all levels of the healthcare system remains the most effective strategy for addressing the current health crisis. Simultaneously, an integrated approach to risk stratification and an approach to treatment is postulated for management of CRE infection within the solid-organ transplant population

Novel Beta-Lactamase Inhibitors: Unlocking Their Potential in Therapy

Carbapenem-resistant Enterobacteriaceae are amongst the most feared pathogens due to severely limited treatment options. In response to this threat, three novel β-lactamase inhibitors have been developed in an attempt to reinvigorate and sustain our current antimicrobial therapies. Avibactam, vaborbactam, and relebactam are inhibitor agents with high affinity to Ambler class A and C β-lactamases and favorable outcomes in current clinical trials. However, although they do possess key similarities, these agents have unique differences which may have important clinical implications. The microbiologic spectrum, pharmacokinetics, and key clinical trials for each of these novel agents are reviewed. A proposed role in therapy and potential novel combinations are examined

Mechanical Properties and Fracture Dynamics of Silicene Membranes

As graphene became one of the most important materials today, there is a renewed interest on others similar structures. One example is silicene, the silicon analogue of graphene. It share some the remarkable graphene properties, such as the Dirac cone, but presents some distinct ones, such as a pronounced structural buckling. We have investigated, through density functional based tight-binding (DFTB), as well as reactive molecular dynamics (using ReaxFF), the mechanical properties of suspended single-layer silicene. We calculated the elastic constants, analyzed the fracture patterns and edge reconstructions. We also addressed the stress distributions, unbuckling mechanisms and the fracture dependence on the temperature. We analysed the differences due to distinct edge morphologies, namely zigzag and armchair

Multidrug-Resistant Bacteria in the Community: An Update

Multidrug-resistant bacteria are among the most important current threats to public health. Typically, they are associated with nosocomial infections. However, some have become prevalent causes of community-acquired infections, such as Neisseria gonorrhoeae, Shigella, Salmonella, and Streptococcus pneumoniae. The community spread of multidrug-resistant bacteria is also a crucial development. An important global threat on the horizon is represented by production of carbapenemases by community-acquired hypervirulent Klebsiella pneumoniae. Such strains have already been found in Asia, Europe, and North America. Prevention of further community spread of multidrug-resistant bacteria is of the utmost importance, and will require a multidisciplinary approach involving all stakeholders

Current trends in the treatment of pneumonia due to multidrug-resistant gram-negative bacteria

Pneumonia is one of the most common infections worldwide. Morbidity, mortality, and healthcare costs increase substantially when pneumonia is caused by multidrug-resistant Gram-negative bacteria (MDR-GNB). The ongoing spread of antimicrobial resistance has made treating MDR-GNB pneumonia increasingly difficult. Fortunately, there have been some recent additions to our antibiotic armamentarium in the US and Europe for MDR-GNB, along with several agents that are in advanced stages of development. In this article, we review the risk factors for and current management of MDR-GNB pneumonia as well as novel agents with activity against these important and challenging pathogens