William Tyndale, Henry VIII and 'The obedience of a Christian man'

William Tyndale’s 'The obedience of a Christian man' has been credited with influencing the Henrician regime’s thinking and propaganda on the subject of obedience to royal authority. According to an anecdote first recorded by the Archdeacon of Nottingham, John Louthe, Henry was so delighted by Tyndale’s tract that he called it "a book for me and all kings to read", and historians have argued that Henry sought to recruit Tyndale as a royal propagandist or diplomat in 1531. This article argues that Louthe’s anecdote was probably a later invention, that Henry disapproved of the 'Obedience' and its author, and that the evidence that Henry sought to recruit Tyndale rather than simply to force him to abjure his heresies is slim. The 'Obedience' contained very little that would have pleased Henry, presenting him as a mere ‘shadow’ of a King, manipulated by evil prelates. While Tyndale rejected rebellion against even tyrannical rulers, this should not be confused with advocacy of obedience of the kind that Henry might approve of, and his 'Obedience' sanctioned disobedience of various kinds. From the outset, remarkably radical ideas were contained within an apparently 'conservative' tradition of English evangelical political thought

Rumor and "common fame": the impeachment of the Duke of Buckingham and public opinion in early Stuart England

This article re-examines the parliamentary impeachment of the Duke of Buckingham, the royal favourite of King Charles I, by placing this event in the broader contexts of political culture and social change in early Stuart England. Buckingham’s enemies based the impeachment on “common fame,” claiming that his faults were a matter of public knowledge. Charles, however, believed that the charges were based on seditious rumors. The impeachment undercut an important element of elite rhetoric that associated rumor with the rebellious multitude, revealing ideological divisions over the nature of grievances and the legitimacy of popular speech. The article contextualizes the impeachment within 1620s underground literature that purported to present the views of the common people, arguing that there was a wider tendency to ventriloquize public opinion. When Buckingham's allies produced their own tracts featuring the persona of the “honest ploughman,” appeals to the authority of public opinion were clearly gaining in strength. By explaining this development in political culture with reference to the growth of a more politically reliable “middling sort”, the article contributes to debates about the relationship between social change and political conflict in early Stuart England

Speaking for the people in early modern England

The voice of the people is assumed to have carried little authority in early modern England. Elites often caricatured the common people as an ignorant multitude and demanded their obedience, deference and silence. Hostility to the popular voice was an important element of contemporary political thought. However, evidence for a very different set of views can be found in numerous polemical tracts written between the Reformation and the English Civil War. These tracts claimed to speak for the people, and sought to represent their alleged grievances to the monarch or parliament. They subverted the rules of petitioning by speaking for ‘the people’ as a whole and appealing to a wide audience, making demands for the redress of grievances that left little room for the royal prerogative. In doing so, they contradicted stereotypes about the multitude, arguing that the people were rational, patriotic and potentially better informed about the threats to the kingdom than the monarch themselves. ‘Public opinion’ was used to confer legitimacy on political and religious demands long before the mass subscription petitioning campaigns of the 1640s

Development of a self-report measure of capability wellbeing for adults: the ICECAP-A

Purpose The benefits of health and social care are not confined to patient health alone and therefore broader measures of wellbeing may be useful for economic evaluation.\ud This paper reports the development of a simple measure of capability wellbeing for adults (ICECAP-A).\ud Methods In-depth, informant-led, interviews to identify the attributes of capability wellbeing were conducted with 36 adults in the UK. Eighteen semi-structured, repeat interviews were carried out to develop a capability-based descriptive system for the measure. Informants were purposively selected to ensure variation in socio-economic status, age, sex, ethnicity and health. Data analysis was carried out inductively and iteratively alongside interviews, and findings were used to shape the questions in later interviews.\ud Results Five over-arching attributes of capability wellbeing were identified for the measure: ‘‘stability’’,‘‘attachment’’, ‘‘achievement’’, ‘‘autonomy’’ and ‘‘enjoyment’’. One item, with four response categories, was developed for each attribute for the ICECAP-A descriptive system.\ud Conclusions The ICECAP-A capability measure represents a departure from traditional health economics outcome measures, by treating health status as an influence over broader attributes of capability wellbeing. Further work is required to value and validate the attributes and test the sensitivity of the ICECAP-A to healthcare interventions

North Jerramungup Fitzgerald area : catchment appraisal report 2001 (reviewed 2007)

This report covers the North Jerramungup Fitzgerald zone, an amalgamation of the smaller sub-catchments of Jacup, Fitzgerald, Mallee Road and part of Hamersley River, North West Jerramungup, North Jerramungup and North Needilup in Western Australia. This report primarily focuses on the agricultural and natural resources at risk within the study area and attempts to identify options to manage the potential risks

South Broomehill-Gnowangerup area : catchment appraisal report 2001

This report covers the South Broomehill-Gnowangerup area in Western Australia, incorporating eight sub-catchments: Wadjekanup, Peringillup, Pindellup, Jam Creek, Woodyarrup, Upper Pallinup, Gnowangerup and Jackitup, and the townsites of Broomehill, Tambellup and Gnowangerup. This report focuses on the agricultural and natural resources at risk and attempts to identify options to manage the potential risks within the area

Cranbrook-Toolbrunup : catchment appraisal report 2001

This report covers the eastern junction of both the Pallinup North Stirling and Kent Frankland sub-regions, comprising of six amalgamated sub-catchments of Pingelup Creek, Solomons Creek, Racecourse Lake, Lake Toolbrunup, Twolganup Brook and Hamilla Hill (west). This report primarily focuses on the agricultural and natural resources at risk within the study area and attempts to identify options to manage the potential risks

Efficacy and safety of ixekizumab through 52 weeks in two phase 3, randomised, controlled clinical trials in patients with active radiographic axial spondyloarthritis (COAST-V and COAST-W).

OBJECTIVES: To investigate the efficacy and safety of ixekizumab for up to 52 weeks in two phase 3 studies of patients with active radiographic axial spondyloarthritis (r-axSpA) who were biological disease-modifying antirheumatic drug (bDMARD)-naive (COAST-V) or tumour necrosis factor inhibitor (TNFi)-experienced (COAST-W). METHODS: Adults with active r-axSpA were randomised 1:1:1:1 (n=341) to 80 mg ixekizumab every 2 (IXE Q2W) or 4 weeks (IXE Q4W), placebo (PBO) or 40 mg adalimumab Q2W (ADA) in COAST-V and 1:1:1 (n=316) to IXE Q2W, IXE Q4W or PBO in COAST-W. At week 16, patients receiving ixekizumab continued their assigned treatment; patients receiving PBO or ADA were rerandomised 1:1 to IXE Q2W or IXE Q4W (PBO/IXE, ADA/IXE) through week 52. RESULTS: In COAST-V, Assessment of SpondyloArthritis international Society 40 (ASAS40) responses rates (intent-to-treat population, non-responder imputation) at weeks 16 and 52 were 48% and 53% (IXE Q4W); 52% and 51% (IXE Q2W); 36% and 51% (ADA/IXE); 19% and 47% (PBO/IXE). Corresponding ASAS40 response rates in COAST-W were 25% and 34% (IXE Q4W); 31% and 31% (IXE Q2W); 14% and 39% (PBO/IXE). Both ixekizumab regimens sustained improvements in disease activity, physical function, objective markers of inflammation, QoL, health status and overall function up to 52 weeks. Safety through 52 weeks of ixekizumab was consistent with safety through 16 weeks. CONCLUSION: The significant efficacy demonstrated with ixekizumab at week 16 was sustained for up to 52 weeks in bDMARD-naive and TNFi-experienced patients. bDMARD-naive patients initially treated with ADA demonstrated further numerical improvements after switching to ixekizumab. Safety findings were consistent with the known safety profile of ixekizumab. TRIAL REGISTRATION NUMBER: NCT02696785/NCT02696798

Illustrating potential efficiency gains from using cost-effectiveness evidence to reallocate Medicare expenditures

This article is available open access through the publisher’s website at the linke below. Copyright @ 2013, International Society for Pharmacoeconomics and Outcomes Research (ISPOR).This article has been made available through the Brunel Open Access Publishing Fund.Objectives - The Centers for Medicare & Medicaid Services does not explicitly use cost-effectiveness information in national coverage determinations. The objective of this study was to illustrate potential efficiency gains from reallocating Medicare expenditures by using cost-effectiveness information, and the consequences for health gains among Medicare beneficiaries. Methods - We included national coverage determinations from 1999 through 2007. Estimates of cost-effectiveness were identified through a literature review. For coverage decisions with an associated cost-effectiveness estimate, we estimated utilization and size of the “unserved” eligible population by using a Medicare claims database (2007) and diagnostic and reimbursement codes. Technology costs originated from the cost-effectiveness literature or were estimated by using reimbursement codes. We illustrated potential aggregate health gains from increasing utilization of dominant interventions (i.e., cost saving and health increasing) and from reallocating expenditures by decreasing investment in cost-ineffective interventions and increasing investment in relatively cost-effective interventions. Results - Complete information was available for 36 interventions. Increasing investment in dominant interventions alone led to an increase of 270,000 quality-adjusted life-years (QALYs) and savings of $12.9 billion. Reallocation of a broader array of interventions yielded an additional 1.8 million QALYs, approximately 0.17 QALYs per affected Medicare beneficiary. Compared with the distribution of resources prior to reallocation, following reallocation a greater proportion was directed to oncology, diagnostic imaging/tests, and the most prevalent diseases. A smaller proportion of resources went to cardiology, treatments (including drugs, surgeries, and medical devices, as opposed to nontreatments such as preventive services), and the least prevalent diseases. Conclusions - Using cost-effectiveness information has the potential to increase the aggregate health of Medicare beneficiaries while maintaining existing spending levels.The Commonwealth Fun