Вплив природних та штучних радіонуклідів на стан здоров'я людини (огляд)

Здійснено огляд основних етапів досліджень з впливу природних та штучних радіонуклідів на стан здоров'я людини. Розглянуто методи профілактики захворювань спровокованих радіоактивним випромінюванням. На основі узагальнення наукової літератури про вплив радіонуклідів на людину запропоновано можливі шляхи розширення лікувальних процедур з використанням водних розчинів, які містять іони калію і мають радіоактивність в діапазоні 20-400 Бк/л, що спричинено радіонуклідом 40К і залежить від концентрації іонів калію

Checkpoints are blind to replication restart and recombination intermediates that result in gross chromosomal rearrangements

Replication fork inactivation can be overcome by homologous recombination, but this can cause gross chromosomal rearrangements that subsequently missegregate at mitosis, driving further chromosome instability. It is unclear when the chromosome rearrangements are generated and whether individual replication problems or the resulting recombination intermediates delay the cell cycle. Here we have investigated checkpoint activation during HR-dependent replication restart using a site-specific replication fork-arrest system. Analysis during a single cell cycle shows that HR-dependent replication intermediates arise in S phase, shortly after replication arrest, and are resolved into acentric and dicentric chromosomes in G2. Despite this, cells progress into mitosis without delay. Neither the DNA damage nor the intra-S phase checkpoints are activated in the first cell cycle, demonstrating that these checkpoints are blind to replication and recombination intermediates as well as to rearranged chromosomes. The dicentrics form anaphase bridges that subsequently break, inducing checkpoint activation in the second cell cycle

Die Europäisierung der öffentlichen Aufgaben

Die zunehmende Europäisierung der öffentlichen Aufgaben ist einer der wichtigsten Trends im Wandel der Staatstätigkeit in der Bundesrepublik Deutschland und in anderen Mitgliedstaaten der Europäischen Union. In diesem Essay werden die Stufen der Europäisierung der Staatstätigkeit nachgezeichnet, in Weiterführung von Lindberg/Scheingold (1970) und Schmitter (1996) quantifiziert und hinsichtlich ihrer Kosten und ihres Nutzen erörtert. Inhalt: Stufen der Europäisierung der öffentlichen Aufgaben Der Europäisierungsgrad der öffentlichen Aufgaben von 1950 bis zum Ende des 20. Jahrhunderts Vom Nutzen und von den Kosten der Europäisierung der öffentlichen Angelegenheiten Verzeichnis der zitierten Literatu

Impact of fracture clustering on the seismic signatures of porous rocks containing aligned fractures

The presence of fractures in a reservoir can have a significant impact on its effective mechanical and hydraulic properties. Many researchers have explored the seismic response of fluid-saturated porous rocks containing aligned planar fractures through the use of analytical models. However, these approaches are limited to the extreme cases of regular and uniform random distributions of fractures. The purpose of this work is to consider more realistic distributions of fractures and to analyze whether and how the frequency-dependent anisotropic seismic properties of the medium can provide information on the characteristics of the fracture network. Particular focus is given to fracture clustering effects resulting from commonly observed fracture distributions. To do so, we have developed a novel hybrid methodology combining the advantages of 1D numerical oscillatory tests, which allows us to consider arbitrary distributions of fractures, and an analytical solution that permits extending these results to account for the effective anisotropy of the medium. A corresponding numerical analysis indicates that the presence of clusters of fractures produces an additional attenuation and velocity dispersion regime compared with that predicted by analytical models. The reason for this is that a fracture cluster behaves as an effective layer and the contrast with respect to the unfractured background produces an additional fluid pressure diffusion length scale. The characteristic frequency of these effects depends on the size and spacing between clusters, the latter being much larger than the typical spacing between individual fractures. Moreover, we find that the effects of fracture clustering are more pronounced in attenuation anisotropy than velocity anisotropy data. Our results indicate that fracture clustering effects on fluid pressure diffusion can be described by two-layer models. This, in turn, provides the basis for extending current analytical models to account for these effects in inversion schemes designed to characterize fractured reservoirs from seismic data.Fil: Barbosa, Nicolás D.. Universite de Lausanne; SuizaFil: Rubino, Jorge German. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Caspari, Eva. Universite de Lausanne; SuizaFil: Holliger, Klaus. Universite de Lausanne; Suiz

A new type of Early Iron Age stela from Tuva (Inner Asia)

Here we present three stelae found on the surface of the Early Iron Age burial mound Tunnug 1 in Tuva Republic, Southern Siberia. An abstract pattern of arcs and lines and the focus on one side of the standing stone makes these stelae substantially different from other known cultural traditions of the Late Bronze Age steppe region. Traceological, petrographic, and geochemical analyses of the material were carried out. The comparison with standing stones of the Deer Stone Khirigsuur complex and the Slab Grave culture do not indicate a direct affiliation with either tradition. The deliberate placement of the stelae on the burial mound and their stratigraphic position indicate a role in funerary ritual activities of the Early Iron Age (9th c. BCE).1. Introduction 2. The stelae at Tunnug 1 3. Methods 4. Traceology 5. Petrography and geochemistry 6. Discussion 7. Conclusio

Mechanical Compliance of Individual Fractures in a Heterogeneous Rock Mass From Production‐Type Full‐Waveform Sonic Data

The mechanical fracture compliance is of interest in a number of geoscientific applications. Seismic borehole methods, especially full-waveform sonic (FWS) data, have indicated their potential to infer the compliance of macroscopic fractures under in situ conditions. These approaches rely on the assumption of a homogeneous background embedding the fractures and, as of yet, compliance estimates for individual fractures are limited to static FWS measurements. In this work, we assess the potential of inferring the compliance of individual fractures from standard, production-type FWS data in the presence of background heterogeneity. We first perform a comparative test on synthetic data to evaluate three approaches known as the transmission, phase, and group time delay methods. The results indicate that the former two produce adequate compliance estimates for scenarios with a strongly heterogeneous background or a damage zone around the fracture. These two methods are then applied to two FWS data sets acquired before and after a hydraulic stimulation campaign in a crystalline rock, which allows to test them on natural and man-made fractures. The transmission method turned out to be unsuitable for the considered data due to its reliance on amplitudes. Conversely, the travel time behavior remained stable and the phase time delay method produced robust and consistent estimates. The results for a newly created hydro-fracture imply the capability of resolving remarkably small compliance values of the order of 10−14 m/Pa. This estimate is one order-of-magnitude smaller than that for the natural fracture, which may help to distinguish between these two fracture types

High-resolution near-infrared data reveal Pazyryk tattooing methods

The tattoos of the Pazyryk ice mummies are of paramount importance for the archaeology of Iron Age Siberia and are often discussed from a broad stylistic and symbolic perspective. However, deeper investigations into this cultural practice were hindered by the inaccessibility of quality data. Here, the authors use high-resolution, near-infrared data in conjunction with experimental evidence to re-examine the tools and techniques employed in Early Iron Age tattooing. The high-quality data allow for the previously unfeasible distinction of artist hands and enable us to put the individual back into the picture of a widespread but rarely preserved prehistoric practice.Introduction Methods Results Discussion Conclusio

Fluid pressure diffusion effects on the seismic reflectivity of a single fracture

When seismic waves travel through a fluid-saturated porous medium containing a fracture, fluid pressure gradients are induced between the compliant fracture and the stiffer embedding background. The resulting equilibration through fluid pressure diffusion (FPD) produces a frequency dependence of the stiffening effect of the fluid saturating the fracture. As the reflectivity of a fracture is mainly controlled by the stiffness contrast with respect to the background, these frequency-dependent effects are expected to affect the fracture reflectivity. The present work explores the P- and S-wave reflectivity of a fracture modeled as a thin porous layer separating two half-spaces. Assuming planar wave propagation and P-wave incidence, this article analyzes the FPD effects on the reflection coefficients through comparisons with a low-frequency approximation of the underlying poroelastic model and an elastic model based on Gassmann's equations. The results indicate that, while the impact of global flow on fracture reflectivity is rather small, FPD effects can be significant, especially for P-waves and low incidence angles. These effects get particularly strong for very thin and compliant, liquid-saturated fractures and embedded in a high-permeability background. In particular, this study suggests that in common environments and typical seismic experiments FPD effects can significantly increase the seismic visibility of fractures.Fil: Barbosa, Nicolás D.. Universite de Lausanne; SuizaFil: Rubino, Jorge German. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. University of Western Ontario; CanadáFil: Caspari, Eva. Universite de Lausanne; SuizaFil: Milani, Marco. Universite de Lausanne; SuizaFil: Holliger, Klaus. Universite de Lausanne; Suiz

Behavior and Impact of Zirconium in the Soil–Plant System: Plant Uptake and Phytotoxicity

Because of the large number of sites they pollute, toxic metals that contaminate terrestrial ecosystems are increasingly of environmental and sanitary concern (Uzu et al. 2010, 2011; Shahid et al. 2011a, b, 2012a). Among such metals is zirconium (Zr), which has the atomic number 40 and is a transition metal that resembles titanium in physical and chemical properties (Zaccone et al. 2008). Zr is widely used in many chemical industry processes and in nuclear reactors (Sandoval et al. 2011; Kamal et al. 2011), owing to its useful properties like hardness, corrosion-resistance and permeable to neutrons (Mushtaq 2012). Hence, the recent increased use of Zr by industry, and the occurrence of the Chernobyl and Fukashima catastrophe have enhanced environmental levels in soil and waters (Yirchenko and Agapkina 1993; Mosulishvili et al. 1994 ; Kruglov et al. 1996)

Estimation of Fracture Compliance From Attenuation and Velocity Analysis of Full‐Waveform Sonic Log Data

In fractured rocks, the amplitudes of propagating seismic waves decay due to various mechanisms, such as geometrical spreading, solid friction, displacement of pore fluid relative to the solid frame, and transmission losses due to energy conversion to reflected and transmitted waves at the fracture interfaces. In this work, we characterize the mechanical properties of individual fractures from P wave velocity changes and transmission losses inferred from static full‐waveform sonic log data. The methodology is validated using synthetic full‐waveform sonic logs and applied to data acquired in a borehole penetrating multiple fractures embedded in a granodioritic rock. To extract the transmission losses from attenuation estimates, we remove the contributions associated with other loss mechanisms. The geometrical spreading correction is inferred from a joint analysis of numerical simulations that emulate the borehole environment and the redundancy of attenuation contributions other than geometrical spreading in multiple acquisitions with different source‐receiver spacing configurations. The intrinsic background attenuation is estimated from measurements acquired in the intact zones. In the fractured zones, the variations with respect to the background attenuation are attributed to transmission losses. Once we have estimated the transmission losses associated with a given fracture, we compute the transmission coefficient, which, on the basis of the linear slip theory, can then be related to the mechanical normal compliance of the fracture. Our results indicate that the estimated mechanical normal compliance ranges from 1 × 10−13 to 1 × 10−12 m/Pa, which, for the size of the considered fractures, is consistent with the experimental evidence available.Fil: Barbosa, Nicolás D.. Universite de Lausanne; Suiza. Universidad de Ginebra; SuizaFil: Caspari, Eva. Universite de Lausanne; SuizaFil: Rubino, Jorge German. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro | Universidad Nacional de Cuyo. Instituto Balseiro. Archivo Histórico del Centro Atómico Bariloche e Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; ArgentinaFil: Greenwood, Andrew. Universite de Lausanne; SuizaFil: Baron, Ludovic. Universite de Lausanne; SuizaFil: Holliger, Klaus. Universite de Lausanne; Suiza. Zhejiang University; Chin